기본 정보
- CAS
20223-84-1- 표준 SMILES
COC([CH2][Hg+])CNC(=O)C1CCC(C)(C(=O)[O-])C1(C)C.O=C([O-])C[S-].[H+].[H+]- InChIKey
JGMQLDDGSMLGDU-UHFFFAOYSA-M- 분자식
- C16H27HgNO6S
- 평균 분자량
- 562 g/mol
- 단동위원소 질량
- 563.126552
개요
Mercaptomerin is an organomercuric compound. Mercury is a heavy, silvery d-block metal and one of six elements that are liquid at or near room temperature and pressure. It is a naturally occuring substance, and combines with other elements such as chlorine, sulfur, or oxygen to form inorganic mercury compounds (salts). Mercury also combines with carbon to make organic mercury compounds. (L1)
이름 및 식별자
- 우선 이름
- Mercaptomerin
- IUPAC
- [3-[(3-carboxylato-2,2,3-trimethylcyclopentanecarbonyl)amino]-2-methoxypropyl]mercury(1+);hydron;2-sulfidoacetate
이름 및 동의어
MERCAPTOMERINMercaptomerineThiomerinMercaptomerinaMercaptomerinum20223-84-158TLO7I2HNDTXSID901046256Mercury, (3-(3-carboxy-2,2,3-trimethylcyclopentanecarboxamido)-2-methoxypropyl)(hydrogen mercaptoacetato)-RefChem:156556DTXCID7015059153-((3-(((carboxymethyl)sulfanyl)mercurio)-2-methoxypropyl)carbamoyl)-1,2,2-trimethylcyclopentane-1-carboxylic acid
이름 더 보기
DiucardynDiucardyn sodiumMercaptomerine sodiqueSodium mercaptomerinThiomerin sodium[3-[(3-carboxylato-2,2,3-trimethylcyclopentanecarbonyl)amino]-2-methoxypropyl]mercury(1+);hydron;2-sulfidoacetateMercaptomerin [INN:BAN]Mercaptomerine [INN-French]
데이터베이스 식별자
- CAS
20223-84-1- PubChem CID
- 30005
- DTXSID
DTXSID901046256
물성
구조 계산 물성
- 극성 표면적
- 120 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 417
실험 및 물리화학적 성질
SolubilityDecomposes 150-155 °C; insol in benzene /Mercaptomerin sodium/
Other Experimental Properties
Discolors polyethylene devices /Mercaptomerin sodium/
White, hygroscopic powder or amorphous solid having a characteristic honeycomb structure; 1 in 50 solution is neutral or slightly alkaline to litmus; freely soluble in water; soluble in alcohol; slightly soluble in chloroform and ether. /Mercaptomerin sodium/
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
RCRA Requirements
D009; A solid waste containing mercury may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Mercury/
OSHA Standards
Permissible Exposure Limit: Table Z-2 8-hr Time Weighted Avg: 0.01 mg/cu m. /Organo alkyl mercury/
Permissible Exposure Limit: Table Z-2 Acceptable Ceiling Concentration: 0.04 mg/cu m. /Organo alkyl mercury/
Vacated 1989 OSHA PEL TWA 0.01 mg/cu m; STEL 0.03 mg/cu m, skin designation, is still enforced in some states. /Mercury (organo) alkyl compounds, as Hg/
Atmospheric Standards
Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Mercaptomerin is included on this list.
EPA Hazardous Waste Number
D009; Mercury. A waste containing mercury may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Mercury/
NIOSH Recommendations
Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.01 mg/cu m. /Mercury (organo) alkyl compounds (as Hg)/
Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 0.03 mg/cu m. /Mercury (organo) alkyl compounds (as Hg)/
Clean Water Act RequirementsToxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Mercury and cmpd/
State Drinking Water Guidelines
(AZ) ARIZONA 3 ug/l /Mercury/
(ME) MAINE 2 ug/l /Mercury/
Federal Drinking Water StandardsEPA 2 ug/l /Mercury/
Federal Drinking Water GuidelinesEPA 2 ug/l /Mercury/
안전 및 보호
Storage ConditionsPROTECT FROM LIGHT & MOISTURE. /MERCAPTOMERIN SODIUM; FROM TABLE/
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Minimum Risk LevelChronic Inhalation: 0.0002 mg/m3 (L134)
Threshold Limit Values (TLV)8 hr Time Weighted Avg (TWA): 0.01 mg/cu m; 15 min Short Term Exposure Limit (STEL): 0.03 mg/cu m. Skin. /Mercury, alkyl cmpds, as Hg/
Immediately Dangerous to Life or Health (IDLH)2 mg/cu m (as Hg) /Mercury (organo) alkyl compounds (as Hg)/
독성 정보
TreatmentMercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)
Health Effects
Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)
Exposure RoutesOral (L7) ; inhalation (L7) ; dermal (L7)
Toxicity Summary
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26)
Signs and SymptomsCommon symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)
Carcinogen ClassificationNo indication of carcinogenicity (not listed by IARC). (L135)
Non-Human Toxicity Excerpts
Mercurial diuretics, including ... mercaptomerin ... appear to have had no significant adverse effect on the eyes. Intraocular pressure in rabbits was reduced slightly by mercaptomerin or mercuderamide given intramuscularly, but not by topical administration.
Kidney slices from dogs and rats were incubated with ... mercaptomerin ... /and/ uptake rate was measured at 2 and 12 minutes. ... Mercaptomerin ... produced significant, dose related inhibition of para-chlormercuribenzoate (PAH) and N-methylnicotinamide (NMN) uptake in both species. ... Rat tissue was more sensitive to mercaptomerin ...
규제 정보
RCRA Requirements
D009; A solid waste containing mercury may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Mercury/
Atmospheric Standards
Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Mercaptomerin is included on this list.
Clean Water Act RequirementsToxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Mercury and cmpd/
State Drinking Water Guidelines
(AZ) ARIZONA 3 ug/l /Mercury/
(ME) MAINE 2 ug/l /Mercury/
Federal Drinking Water StandardsEPA 2 ug/l /Mercury/
Federal Drinking Water GuidelinesEPA 2 ug/l /Mercury/
화학 및 산업
약리 정보
Metabolism/Metabolites
Organic mercury is absorbed mainly by the gastrointestinal tract, then distributed throughout the body via the bloodstream. Organic mercury complexes with free cysteine and the cysteine and sulfhydryl groups on proteins such as haemoglobin. These complexes are able to mimic methionine and thus be transported throughout the body, including through the blood-brain barrier and placenta. Organic mercury is metabolized into inorganic mercury, which is eventually excreted in the urine and faeces. (T11)
Absorption, Distribution and Excretion2 ML MERCAPTOMERIN SODIUM INJECTED IV: 60-90% EXCRETED IN URINE DURING 24 HR. 2 ML INJECTED SUBCUTANEOUS: 50% EXCRETED IN URINE WITHIN 2-3 HR. /MERCAPTOMERIN SODIUM; FROM TABLE/
용도 및 제조
UsesMEDICATION (VET)
Methods of ManufacturingLehman, US patent 2,576,349 (1951 to Wyeth); Wendt, Bruce, J Org Chem 23: 1448 (1958); Wendt, US patent 2,834,795 (1958 to Am Home Prod). /Mercaptomerin sodium/
Formulations/Preparations
Mercaptomerin Sodium Injection (USP). ... A sterile solution in water for injections, containing 118 to 132 mg in 1 ml; pH 8 to 9.5. Nord P (Injectabile Mercaptomerini) is similar. /Mercaptomerin Sodium/
Proprietary names: Thiomerin (Wyeth, Canada; Wyeth, USA). /Mercaptomerin Sodium/
VET: CONTAINS 33% MERCURY. WHEN DILUTED TO CONTAIN 125 MG/ML EACH ML CONTAINS 40 MG ELEMENTAL MERCURY. /MERCAPTOMERIN SODIUM/
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