베타메타손

Celestone

HCID 3003CAS 378-44-9

기본 정보

표준 SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO
InChIKey
UREBDLICKHMUKA-UHFFFAOYSA-N
분자식
C22H29FO5
평균 분자량
392.5 g/mol
단동위원소 질량
392.19990218

이름 및 식별자

우선 이름
Celestone
IUPAC
9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
현지명
베타메타손
영어명
Betamethasone
분자식
C22H29FO5
분자량
392.47

이름 및 동의어

CelestoneHormezonBebate.beta.-Methasone9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one.beta.-Methasone alcoholC22H29FO59-Fluoro-16.beta.-methylprednisolonePrednisolone, 9-fluoro-16.beta.-methyl-GF120918A9.alpha.-Fluoro-16.beta.-methylprednisolone9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
이름 더 보기
베타메타손베타메타솜BetamethasonBetametasonebetamethasone standardC22H29O5FDermabet17,21-trihydrFLUBENISOLONEBetamethazoneDexamethasone EP Impurity B
MLS000686794Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16.beta.-methyl-SCHEMBL2757815CHEBI:93851HMS3259J08HMS3267M14HMS5079A12HMS5079N09

데이터베이스 식별자

CAS
378-44-9
PubChem CID
3003
ChEBI
CHEBI:93851

물성

구조 계산 물성

XLogP
1.9
극성 표면적
94.8 Ų
수소 결합 공여자 수
3
수소 결합 수용자 수
6
회전 가능 결합 수
2
무거운 원자 수
28

물리화학적 성질

녹는점
235 · 235-237°C
끓는 점
568.2 · 568.2±50.0 °C(Predicted)
밀도
1.1283 · 1.1283 (estimate)
굴절률
118 ° · 118 ° (C=1, Dioxane)
저장 조건
0 · 0-6°C
용해도
물에 거의 녹지 않고, 무수 에탄올에 거의 녹지 않으며, 염화메틸렌에 아주 약간 녹습니다.

화학적 성질

White to Off-White Solid

안전 및 규제

안전 데이터

wgk
2
rtecs
TU4000000
독성
LD50 oral in mouse: > 4500mg/kg
HS 번호
29379000
risk_code
40-48/20/21-61
hazard_code
Xi,Xn,T

화학 및 산업

응용 분야 · 3건

개요Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy.

용도Betamethasone is a glucocorticoid used as an anti-inflammatory agent.

일반 설명Betamethasone, 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,is available as a variety of ester derivatives.Betamethasone valerate, USP (17-valerate)Betamethasone acetate, USP (21-acetate)Betamethasone sodium phosphate, USP (21-sodiumphosphate)Betamethasone dipropionate, USP (17-propionate,21-propionate).

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
山东雨禾医药科技有限公司15263077727
南京兰亚化工贸易有限公司+86-25-8331-5620 · [email protected]

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