다이아지논

O-디에틸-O-포스포르티오에이트,다이아지논 · 다이아지논 · 디아지논 · Anti · Diazinone · Diazide · dimpylate · BASUDIN

식별자 및 물리적 특성

CAS No.	333-41-5
분자식	C12H21N2O3PS
평균 분자량	304.35 g/mol
단동위원소 질량	304.10105016 g/mol
SMILES	CCOP(=S)(OCC)Oc1cc(C)nc(C(C)C)n1
InChIKey	FHIVAFMUCKRCQO-UHFFFAOYSA-N
PubChem CID	3017
ChEMBL	CHEMBL388560
ChEBI	CHEBI:34682
EC No.	206-373-8
DTXSID	DTXSID9020407
현지명	다이아지논

화학 및 물리적 성질

XLogP	3.8
극성 표면적	85.6
수소 결합 공여자 수	0
수소 결합 수용자 수	6
회전 가능 결합 수	7
무거운 원자 수	19
형식 전하	0
복잡도	307
물질 분류	Teratogens
SpringerMaterials Properties	Boiling point
농약	PesticidesAcaricides, InsecticidesActive substance -> EU Pesticides database: Not approvedPesticides -> Organophosphate InsecticidesPesticides -> Insecticides -> Organophosphorus insecticides -> Organothiophosphate insecticides -> Heterocyclic organothiophosphate insecticidesRepellents, Veterinary substances, Acaricides, Insecticides
LogP(분배 계수)	log Kow = 3.813.11
냄새	Faint ester-like odor
밀도	1.117 at 68 °F (USCG, 1999) - Denser than waterwill sinkSpecific gravity: 1.116-1.118 at 20 °C/4 °CRelative density (water = 1): 1.11.12
Color/Form	Colorless oilClear, colorless liquid
용해도	less than 1 mg/mL at 75 °F (NTP, 1992)Completely miscible with common organic solvents, e.g. ethers, alcohols, benzene, toluene, hexane, cyclohexane, dichloromethane, acetone, petroleum oils.Freely soluble in ketonesSolubility in water: 0.004% at 20 °CSolubility in water: 60 mg/L at 20 °CIn water, 40 mg/L at 25 °CChloroform: Slightly Soluble
인화점	82 to 105 °F (commercial solutions) (NTP, 1992)104.4 °C c.c.180 °F
Animal Drugs	Pharmaceuticals -> UK Veterinary Medicines Directorate List
Endocrine Disruptors	Potential endocrine disrupting compound
끓는 점	Decomposes >248 °F (NTP, 1992)BP: 125 °C at 1 mm Hg306°C
녹는점	>120°C (dec.)
증기압	1.2 x 10-2 Pa (25 °C)
굴절률	nD20 1.4978-1.4981
저장 조건	APPROX 4°C
pKa(산도 계수)	1.21±0.30(Predicted)
물리적 상태	Liquid
색상	Light brown to brown
생물학적 소스	rabbit
용해도	약간 용해됨. 0.004g/100mL
Merck	13,3019
BRN	273790
헨리 상수	4.6×101 mol/(m3Pa) at 25℃, Muir et al. (2004)
안정성	수분에 민감한
주요 응용	농업환경
InChI	1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3
InChIKey	FHIVAFMUCKRCQO-UHFFFAOYSA-N
SMILES	CCOP(=S)(OCC)Oc1cc(C)nc(n1)C(C)C
NIST	Diazinone(333-41-5)
EPA	Diazinon (333-41-5)

화학적 성질

Diazinon is available as a colorless or dark brown liquid. It is sparingly soluble in water but very soluble in petroleum ether, alcohol, and benzene. Diazinon is used for the control of a variety of agricultural and household pests. These include pests in soil, on ornamental plants, fruit, vegetable, crops pests, and household pests like fl ies, fl eas, and cockroaches. Diazinon undergoes decomposition on heating above 120°C and produces toxic fumes, such as nitrogen oxides, phosphorous oxides, and sulfur oxides. It reacts with strong acids and alkalis with the possible formation of highly toxic tetra ethyl thiopyrophosphates. Diazinon is classifi ed as an RUP. Depending on the type of formulation, diazinon is classifi ed as toxicity class II, meaning moderately toxic, or toxicity class III, meaning slightly toxic.

안전 및 규제

GHS 분류	WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)DangerH302 (72.8%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P264, P270, P273, P280, P301+P317, P302+P352, P308+P316, P317, P318, P319, P321, P330, P362+P364, P391, P405, and P501 (click each P-code to see the statement)
규제 정보	Hazard Traits - CarcinogenicityDevelopmental ToxicityEnvironmental toxNeurotoxicityCommission Regulation (EC) No 451/20002007/393Diazinon: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보	IMAP assessments - Phosphorothioic acid, O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] ester: Human health tier I assessment
운송 라벨(DOT)	Poison
화재 위험	Not flammable. POISONOUS GASES ARE PRODUCED WHEN HEATED. Oxides of sulfur and of phosphorus are generated in fires. (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion if formulations contain flammable/explosive solvents.
화재 가능성	PRACTICALLY NONFLAMMABLE.
건강 유해성	LIQUID: POISONOUS IF SWALLOWED. Irritating to skin and eyes. (USCG, 1999)
유해성 요약	Diazinon is the common name of an organophosphorus pesticide used to control pest insects in soil, on ornamental plants, and on fruit and vegetable field crops. It was formerly used as the active ingredient in household and garden products used to control pests such as flies, fleas, and cockroaches. Diazinon is a synthetic chemical, it does not occur naturally in the environment. Pure diazinon is colorless and practically odorless oil. Preparations used in agriculture and by exterminators contain 85-90% diazinon and appear as a pale to dark-brown liquid. Diazinon preparations sold in the past for home and garden use contained 1-5% diazinon in a liquid or as solid granules. Most diazinon used is in liquid form, but it is possible to be exposed to the solid form. Diazinon does not dissolve easily in water and does not burn easily.

용도

개요

Diazinon is a non-systemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon functions as the inhibitor of acetylcholinesterase (AChE), which breaks down the neurotransmitter acetylcholine (ACh) into [choline] and an acetate group. The inhibition of the AChE causes an abnormal accumulation of ACh in the synaptic cleft. However, recent studies have shown that diazinon and other kinds of organophosphate can cause neural toxicity through causing oxidative stress in the neural cells.

용도

Diazinon is used to control a wide range of sucking and chewing insects and mites in a very wide range of crops and is also used as a veterinary ectoparasiticide.

일반 설명

Diazinon is available in the form of a colourless or dark brown liquid. It is sparingly soluble in water but very soluble in petroleum ether, alcohol, and benzene. Diazinon is used for the control of a variety of agriculture and household pests. These include pests in soil, on ornamental plants, fruit, vegetable, and crops and household pests like flies, fleas, and cockroaches. Diazinon undergoes decomposition on heating above 120°C and produces toxic fumes such as nitrogen oxides, phosphorus oxides, and sulphur oxides. It reacts with strong acids and alkalis with possible formation of highly toxic tetra ethyl thiopyrophosphates. Diazinon is classified as a RUP. Depending on the type of formulation, diazinon is classified as toxicity class II, meaning moderately toxic, or toxicity class III, meaning slightly toxic.