Ranitidine Hydrochloride
기본 정보
- CAS
66357-59-3- 표준 SMILES
CN/C(=C\[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1.Cl- InChIKey
GGWBHVILAJZWKJ-KJEVSKRMSA-N- 분자식
- C13H23ClN4O3S
- 평균 분자량
- 350.87 g/mol
- 단동위원소 질량
- 350.1179395
개요
Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.
이름 및 식별자
- 우선 이름
- Ranitidine Hydrochloride
- IUPAC
- (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride
- 영어명
- Ranitidine Hydrochloride
- 분자식
- C13H22N4O3S.ClH
- 분자량
- 350.87
이름 및 동의어
ranitidine hydrochloride66357-59-3Ranitidine HCLAzantacRaniblocNu-RanitRani-QFendibinaGastridinaGastrolavKuracidAlquen
이름 더 보기
noctoneRanitidine HydrochloorideRANITIDINEHYDROCHLORIDE,USPRanitidine hydrochloride CRSZamecZANTACMelfaxZintacranidilah19065
Zantac In Plastic ContainerRani-nertonZANTAC 300RaniticWal-zan 75Ranitidine-Acid ReducerZantac 75Zantac 150
데이터베이스 식별자
- CAS
66357-59-3、71130-06-8- PubChem CID
- 3033332
- ChEMBL
CHEMBL2110372- EC Number
- 266-333-0、275-207-4
물성
구조 계산 물성
- 극성 표면적
- 112 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 347
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Pharmaceuticals
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Ulcer Agents; Histamine H2 Antagonists; Gastrointestinal Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 134 °C · 134°C (dec.)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 1.8 mg/mL
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 8.27 · 8.27 (pKa2)
- 색상
- 갈색을 띤 노란색
- 수용성
- 2 · 물, 2-하이드록시프로필-베타-사이클로덱스트린, 아세트산, 메탄올, 에탄올 및 디메틸 설폭사이드에 용해됩니다. 클로로포름에 불용성.
- Merck
- 14 · 14,8110
- BCS Class
- 3 · 3/1
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChI
- InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;
- InChIKey
- GGWBHVILAJZWKJ-KJEVSKRMSA-N
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 3.9% (3 of 76) of reports.
Danger
H315 (85.5%): Causes skin irritation [Warning Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 76 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
유해성 정보
Regulatory InformationRanitidine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Allergic contact dermatitis reported in pharmaceutical workers; [Kanerva, p. 1170] Ranitidine is a drug to reduce acid secretion in the stomach. Many side effects have been reported after ingestion of therapeutic doses including, rarely, drug-induced hepatitis. [HSDB]
Hazard Classes and Categories
Skin Irrit. 2 (100%)
Skin Irrit. 2 (85.5%)
독성 정보
Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Ranitidine hydrochloride
vLess-DILI-concern
5
화학 및 산업
약리 정보
FDA Pharmacological Classification
RANITIDINE HYDROCHLORIDE
Histamine-2 Receptor Antagonist [EPC]; Histamine H2 Receptor Antagonists [MoA]
MeSH Pharmacological Classification
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
용도 및 제조
UsesUse (kg) in Switzerland (2009): >1000
응용 분야
용도An H-2 histamine receptor antagonistRanitidine hydrochloride is mainly used as an H2-receptor antagonist and helps in the treatment of gastrointestinal lesions because of excessive gastric acid secretion. It also serves as an antiulcer drug.
관련 반응
5건
화합물 노트
불러오는 중…