기본 정보
- CAS
108341-18-0- 표준 SMILES
NC[C@H](O)c1ccc(O)c(O)c1.O.O=C(O)[C@H](O)[C@@H](O)C(=O)O- InChIKey
LNBCGLZYLJMGKP-LUDZCAPTSA-N- 분자식
- C12H19NO10
- 평균 분자량
- 337.28 g/mol
- 단동위원소 질량
- 337.10089581
개요
Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine bitartrate acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action.
이름 및 식별자
- 우선 이름
- Norepinephrine Bitartrate
- IUPAC
- 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;(2R,3R)-2,3-dihydroxybutanedioic acid;hydrate
- 영어명
- L-NORADRENALINE BITARTRATE
- 분자식
- C8H11NO3.C4H6O6.H2O
- 분자량
- 337.28
이름 및 동의어
108341-18-0Norepinephrine bitartrateNorepinephrine bitartrate monohydrateL-Noradrenaline bitartrate monohydrateBinodrenalArterenol, tartrate, monohydrateIFY5PE3ZRWLevarterenol bitartrate monohydrateDTXSID2047806Noradrenaline (as tartrate)Norepinephrine d-bitartrateNorepinephrine Phenolic
이름 더 보기
NORADRENALINENorepinephrine bitartrate hydrateNOREPINEPHRINE BITARTRATE USPL-ARTERENOL BITARTRATEEpinephrine Impurity 28L-Nradrenaline bitartrateL-NORADRENALINE BITARTRATENoradrenaline tartrate CRSL-NOREPINEPHRINE BITARTRATE(-)-ARTERENOL BITARTRATE SALT
RefChem:56522NOREPINEPHR BITARTNorepinephrine (Bitartrate)DTXCID0070998Norepinephrine l-Tartrate (1:1)NOREPINEPHRINE in Sodium ChlorideLEVOPHED(R) NOREPINEPHRINE BITARTRATENOREPINEPHRINE BITARTRATE IN 5% DEXTROSE
데이터베이스 식별자
물성
구조 계산 물성
- 극성 표면적
- 203 Ų
- 수소 결합 공여자 수
- 9
- 수소 결합 수용자 수
- 11
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 23
- 형식 전하
- 0
- 복잡도
- 276
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 100 · 100-104 °C(lit.)
- 굴절률
- -11 ° · -11 ° (C=5, H2O)
- 저장 조건
- Refrigerator
- 용해도
- 2 O: · H2O: 가용성50mg/mL, 투명
- 산도 계수 (pKa)
- 8.64 · 8.64(at 25℃)
- 물리적 상태
- 고체
- 색상
- 하얀색
- 수용성
- 1 mg/mL · water: 1mg/mL
- BRN
- 4078502 · 4078502
- InChI
- InChI=1/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-;1-,2-/s3
- InChIKey
- WNPNNLQNNJQYFA-KBOIKTAVNA-N
- SMILES
- [C@H](C1C=CC(O)=C(O)C=1)(O)CN.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:0,12,17,r|
화학적 성질
White Solid
안전 및 규제
GHS 분류
GHS Classification
Danger
H300 (91.1%): Fatal if swallowed [Danger Acute toxicity, oral]
P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 45 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
유해성 정보
Hazard Classes and Categories
Acute Tox. 4 (100%)
Acute Tox. 1 (91.1%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Norepinephrine bitartrate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 3
- rtecs
- DN6750000
- ridadr
- UN 2811 6.1/PG 2
- HS 번호
- 2937901500
- risk_code
- 26/27/28-28
- hazard_code
- T+
- safety_code
- 22-26-36/37/39-45-36/37-28
- 포장분류
- III
- 위험 등급
- 6.1
- Hazard Classifications
- Acute Tox. 1 DermalAcute Tox. 2 Oral
- 스토리지 클래스
- 6.1B - Non-combustible acute toxic Cat. 1 and 2very toxic hazardous materials
화학 및 산업
약리 정보
FDA Pharmacological Classification
LEVOPHED(R) NOREPINEPHRINE BITARTRATE
Catecholamine [EPC]; Catecholamines [CS]
NOREPINEPHRINE (BITARTRATE)
Catecholamine [EPC]; Catecholamines [CS]
NOREPINEPHRINE BITARTRATE
Catecholamines [CS]; Catecholamine [EPC]
MeSH Pharmacological Classification
Drugs that selectively bind to and activate alpha adrenergic receptors.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs used to cause constriction of the blood vessels.
응용 분야
용도Demethylated precursor of epinephrine (adrenaline). It is a sympathomimetic hormone produced by the adrenal gland.
공급사100 곳
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海金试生化科技有限公司18601717983 18601717983 · [email protected]
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