메르캅토메린나트륨

메르캅토메린나트륨 · Letorin · Thiomerin sodium · Diucardyn sodium · mercaptomerin sodium · Mercaptomerine sodique · [[3-[[(3-Sodiooxycarbonyl-2,2,3-trimethylcyclopentyl)carbonyl]amino]-2-methoxypropyl]mercurio(II)thio]acetic acid sodium salt · Mercurate(2-), [3-[[(3-carboxylato-2,2,3-trimethylcyclopentyl)carbonyl-κO]amino]-2-methoxypropyl-κC][2-(mercapto-κS)acetato(2-)-κO]-, sodium (1:2), (T-4)-

https://huagongshe.com/ko/chemical/30556

식별자 및 물리적 특성

CAS No.	21259-76-7
분자식	C16H25HgNNa2O6S
평균 분자량	606 g/mol
단동위원소 질량	607.09044008 g/mol
SMILES	COC(CNC(=O)C1CCC(C)(C(=O)[O-])C1(C)C)[CH2][Hg][S]CC(=O)[O-].[Na+].[Na+]
InChIKey	RQXWFEXQGWCOGQ-UHFFFAOYSA-K
PubChem CID	30556
EC No.	244-298-2
DTXSID	DTXSID801016486
현지명	메르캅토메린나트륨

화학 및 물리적 성질

극성 표면적	144
수소 결합 공여자 수	1
수소 결합 수용자 수	7
회전 가능 결합 수	7
무거운 원자 수	27
형식 전하	0
복잡도	504
녹는점	150-155 °C (decomp)

안전 및 규제

Minimum Risk Level	Chronic Inhalation: 0.0002 mg/m3 (L134)
Treatment	Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)
건강 영향	Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)
노출 경로	Oral (L7)inhalation (L7)dermal (L7)
독성 요약	High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Organic mercury exerts developmental effects by binding to tubulin, preventing microtubule assembly and causing mitotic inhibition. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26)
Signs and Symptoms	Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)
Carcinogen Classification	No indication of carcinogenicity (not listed by IARC). (L135)