디이소프로필 수소 인산염
디아이소프로필수소인산염 · 디이소프로필수소인산염 · 디아이소프로필수소인산염(DIISOPROPYLHYDROGENPHOSPHITE) · DIISOPROPYL PHOSPHONATE · Diisopropylphosphine oxide · Phosphonic acid, bis(1-methylethyl) ester · 3P-230 · (iPrO)2P(O)H
식별자 및 물리적 특성
| CAS No. | 1809-20-7 |
|---|---|
| 분자식 | C6H15O3P |
| 평균 분자량 | 166.16 g/mol |
| 단동위원소 질량 | 166.07588133 g/mol |
| SMILES | CC(C)O[PH](=O)OC(C)C |
| InChIKey | BLKXLEPPVDUHBY-UHFFFAOYSA-N |
| PubChem CID | 3072 |
| EC No. | 217-317-7 |
| DTXSID | DTXSID7061988 |
| 현지명 | 디이소프로필 수소 인산염 |
화학 및 물리적 성질
| XLogP | 0.4 |
|---|---|
| 극성 표면적 | 35.5 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 4 |
| 무거운 원자 수 | 10 |
| 형식 전하 | 0 |
| 복잡도 | 99 |
| 증기압 | 0.54 [mmHg] |
| Physical Description | Liquid[Alfa Aesar MSDS] |
| 끓는 점 | 71 °C (8 mmHg) |
| 밀도 | 0.997 |
| 굴절률 | 1.4065-1.4085 |
| 인화점 | 69°C |
| 저장 조건 | Inert atmosphere,Room Temperature |
| 용해도 | 클로로포름(소량으로 용해), 메탄올(소량으로 용해) |
| 물리적 상태 | 액체 |
| 비중 | 1 |
| 색상 | 무색의 |
| 용해도 | 녹는 |
| InChI | InChI=1S/C6H15O3P/c1-5(2)8-10(7)9-6(3)4/h5-6,10H,1-4H3 |
| InChIKey | BLKXLEPPVDUHBY-UHFFFAOYSA-N |
| SMILES | P(=O)(OC(C)C)OC(C)C |
| NIST | Phosphonic acid, di-isopropyl ester(1809-20-7) |
| EPA | Phosphonic acid, bis(1-methylethyl) ester (1809-20-7) |
화학적 성질
clear colourless liquid, corrosive, soluble in organic solvents such as ethanol.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 78.2% (43 of 55) of all reports.WarningH302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]H315 (18.2%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (20%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (16.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 55 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 43 of 55 reports by companies.There are 9 notifications provided by 12 of 55 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | Chemical: Phosphonic acid, bis(1-methylethyl) esterPhosphonic acid, bis(1-methylethyl) ester: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| 유해성 요약 | Causes convulsions and lung changes in inhalation lethal-concentration studies of rats, mice, and guinea pigs[RTECS] A skin and strong eye irritantHarmful by inhalationToxic by ingestion[Alfa Aesar MSDS] See Dimethyl hydrogen phosphite. |
| Hazard Classes and Categories | Acute Tox. 4 (20%)Skin Irrit. 2 (18.2%)Eye Irrit. 2A (20%)STOT SE 3 (16.4%) |
| 유해 작용 | Neurotoxin - Other CNS neurotoxin |
| Toxicity Data | LC50 (rat) = 9,600 mg/m3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | SZ7660000 |
| 운송 번호(UN) | 3265 |
| 독성 | guinea pig,LC50,inhalation,9010mg/m3 (9010mg/m3),LUNGS, THORAX, OR RESPIRATION: OTHER CHANGESGASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 29(11), Pg. 51, 1985. |
| 관세 코드 | 29209085 |
| 위험 문구(R) | 36/37/38-22 |
| 위험 표시 | Xn |
| 안전 문구(S) | 37/39-26 |
| 기존화학 물질 | KE-10960 |
제조 및 합성 방법
제조 방법
Diisopropyl phosphite is prepared by directly reacting isopropanol with phosphorus trichloride.3(CH3)2CHOH+PCl3→[(CH3)2CHO]2POH+2HCl↑+(CH3)2CHClAt a ratio of 3:1 (mol), continuously feed 215kg/h of isopropanol and 150kg/h of phosphorus trichloride. When mixed, this results in a violent reaction that generates hydrogen chloride gas. This gas is quickly removed from the mixing pot using vacuum mercury. The crude ester produced is then heated in a falling film type spinner deacidification device and further deacidified. The resulting product is then cooled to below 40°C and obtained with a content of 92%-95% and a yield of 95%～98%.