폴리믹신 B 황산염
폴리믹신B황산염 · 폴리믹신B황산염(POLYMYXINBSULFATE) · POLYMYXIN B · POLYMYXIN B SULPHATE · POLYMIXIN B SULFATE · POLYMIXIN B SULPHATE · AEROSPORIN · polymyxin B sulfate usp
식별자 및 물리적 특성
| CAS No. | 1405-20-5 |
|---|---|
| 분자식 | C56H100N16O17S |
| 평균 분자량 | 1,301.56 g/mol |
| SMILES | CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC(=O)C(NC(=O)C(CCN)NC(=O)C(CCO)NC(=O)C(CCN)NC=O)CCNC(=O)C(CCO)NC(=O)C(CCN)NC(=O)C(CCN)NC1=O.O=S(=O)(O)O |
| PubChem CID | 3083708 |
| 현지명 | 폴리믹신 B 황산염 |
화학 및 물리적 성질
| 녹는점 | 217-220°C (dec.) |
|---|---|
| 저장 조건 | 2-8°C |
| 용해도 | H2O: 50 mg/mL |
| pKa(산도 계수) | pKa 8.9 (Uncertain) |
| 물리적 상태 | 가루 |
| 색상 | 무색 또는 약간 노란색 |
| pH | pH (10g/L, 25℃) : 4.5～7.0 |
| 생물학적 소스 | Pseudomonas aeruginosa |
| 용해도 | 50mg/ml/n에서 물에 용해됨 |
| Merck | 14,7573 |
| 안정성 | 흡습성 |
| InChIKey | HFMDLUQUEXNBOP-UHFFFAOYSA-N |
| LogP(분배 계수) | -6.361 (est) |
| EPA | Polymixin B sulfate (1405-20-5) |
화학적 성질
White Solid
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| RTECS 번호 | TR1150000 |
| 운송 번호(UN) | 3249 |
| 독성 | dog,LDLo,intracrebral,320ug/kg (0.32mg/kg),BEHAVIORAL: COMA,British Journal of Pharmacology and Chemotherapy. Vol. 23, Pg. 552, 1964. |
| 관세 코드 | 2941 90 00 |
| 위험 문구(R) | 22 |
| 위험 표시 | Xn |
| 안전 문구(S) | 22-24/25 |
| 포장분류 | III |
| 위험 등급 | 6.1(b)Acute Tox. 4 Oral |
| 기존화학 물질 | KE-05-1072 |
| F 고인화성물질 | 3-8-10 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.
용도
Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.
일반 설명
Polymyxin (Aerosporin) was discovered in 1947 almost simultaneouslyin three separate laboratories in the UnitedStates and Great Britain. As often happens whensimilar discoveries are made in widely separated laboratories,differences in nomenclature, referring to both theantibiotic-producing organism and the antibiotic itself, appearedin references to the polymyxins. Because the organismsfirst designated as Bacillus polymyxa and B.aerosporus Greer were found to be identical species, thename B. polymyxa is used to refer to all of the strains thatproduce the closely related polypeptides called polymyxins.Other organisms (e.g., see “Colistin” later) also producepolymyxins. Identified so far are polymyxins A, B1,B2, C, D1, D2, M, colistin A (polymyxin E1), colistin B(polymyxin E2), circulins A and B, and polypeptin. Theknown structures of this group and their properties havebeen reviewed by Vogler and Studer. Of these,polymyxin B as the sulfate usually is used in medicine because,when used systemically, it causes less kidney damagethan the others. Polymyxin B sulfate is a nearly odorless, white to buff powder. It is freely soluble in water and slightly soluble in alcohol.