유비퀴틴교차반응성단백질

유비퀴틴교차반응성단백질 · C00496 · Ubiquitin-13C,15N human · ubiquitin cross-reactive protein · Ubiquitin-13C,15N human >=98 atom %, >=90% (CP), recombinant, expressed in E. coli

https://huagongshe.com/ko/chemical/311

식별자 및 물리적 특성

CAS No.	60267-61-0
분자식	C6H8O7
평균 분자량	192.12 g/mol
단동위원소 질량	192.02700259 g/mol
SMILES	O=C(O)CC(O)(CC(=O)O)C(=O)O
InChIKey	KRKNYBCHXYNGOX-UHFFFAOYSA-N
PubChem CID	311
ChEMBL	CHEMBL1261
ChEBI	CHEBI:30769
EC No.	201-069-1
DTXSID	DTXSID3020332
현지명	유비퀴틴교차반응성단백질

화학 및 물리적 성질

XLogP	-1.7
극성 표면적	132
수소 결합 공여자 수	4
수소 결합 수용자 수	7
회전 가능 결합 수	5
무거운 원자 수	13
형식 전하	0
복잡도	227
LogP(분배 계수)	-1.64log Kow = -1.64-1.7
LogS	0.51
냄새	Odorless
맛	Strongly acidic tastePleasant, sweet, tart taste
밀도	1.54 at 68 °F (USCG, 1999) - Denser than waterwill sink1.665 g/cu cm at 20 °CBULK DENSITY: 56.2 LB/CU FTHEAT OF SOLN: -3.9 KCAL/MOLEBUFFERING INDEX: 2.46STD FREE ENERGY OF ANION FORMATION: -278.8 KCAL FOR AQ SOLN @ 25 °CDensity: 1.542 g/cu cm /Citric acid monohydrate/White, odorless crystals, granules or powdercool, saline taste. Stable in air, becomes anhydrous at 150 °C. Density: 1.814. Soluble in 3 parts water, 0.6 parts boiling water. Insoluble in alcohol. The aqueous solution is slightly alkaline to litmus. pH about 8 /Sodium citrate dihydrate/
Viscosity	2.549 cP 30% aqueous solution at 20 °C
Color/Form	Crystalsmonoclinic holohedracrystallizes from hot concentrated aqueous solutionColorless, translucent crystals or powderRhombic crystals from water with 1 mol of water of crystallization
용해도	greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)592000Very soluble in waterfreely soluble in ethanolsoluble in etherIn water, 3.83X10+5 mg/L at 25 °CSolubility in water: 54.0% w/w at 10 °C59.2% at 20 °C64.3% at 30 °C68.6% at 40 °C70.9% at 50 °C73.5% at 60 °C76.2% at 70 °C78.8% at 80 °C81.4% at 90 °C84.0% at 100 °CVery soluble in ethanolsoluble in ether, ethyl acetateinsoluble in benzene, chloroformTris-HCl, pH 7.5: 1.0—1.10mg/mL, clear to slightly hazy, colorless
Corrosivity	WILL CORRODE COPPER, ZINC, ALUMINUM AND THEIR ALLOYS
인화점	100 °C
끓는 점	Decomposes (NTP, 1992)
Decomposition	When heated to decomposition it emits acrid smoke and fumes.Behavior in fire: melts and decomposes. The reaction is not hazardous.Decomposes at 175 °C
저장 조건	-20°C
물리적 상태	saline suspension
생물학적 소스	human

안전 및 규제

GHS 분류	WarningH319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 8.2% (359 of 4373) of reports.
규제 정보	Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-Regulation (EC) No 1331/20081,2,3-Propanetricarboxylic acid, 2-hydroxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 08-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15451Citric acid: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - Citric acid: Human health tier II assessmentIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-: Environment tier I assessment
화재 위험	Behavior in Fire: Melts and decomposes. The reaction is not hazardous. (USCG, 1999)Combustible. Finely dispersed particles form explosive mixtures in air.
화재 가능성	Combustible liquid
건강 유해성	Inhalation of dust irritates nose and throat. Contact with eyes causes irritation. (USCG, 1999)
유해성 요약	An irritant to the throat and eyes[CAMEO] Concentrated solutions can cause severe eye damage and blindnessAnimals fed 1.2% citric acid for 90 weeks showed no adverse effects except erosion of tooth enamel. [CHEMINFO]
FDA 요건	Substance added directly to human food affirmed as generally recognized as safe (GRAS).Citric acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

용도

Ubiquitin, N-terminal FLAG-tagged can replace the ubiquitin in formation of poly-ubiquitin—protein conjugates. The FLAG tag enables separation and enrichment of the protein conjugates on anti-FLAG affinity columns and detection of conjugates in western blot by anti-FLAG antibodies.

일반 설명

Ubiquitin, a globular protein is made of 76 amino acids and has lysine residues on its surface. It has a molecular weight of 8565 Da.