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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 3111생성일: 2026년 10월 26일

Metamizole

[(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid · [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid · Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-

https://huagongshe.com/ko/chemical/3111

Metamizole 분자 구조식

식별자 및 물리적 특성

CAS No.50567-35-6
분자식C13H17N3O4S
평균 분자량311.36 g/mol
단동위원소 질량311.09397702 g/mol
SMILESCc1c(N(C)CS(=O)(=O)O)c(=O)n(-c2ccccc2)n1C
InChIKeyLVWZTYCIRDMTEY-UHFFFAOYSA-N
PubChem CID3111
ChEMBLCHEMBL461522
ChEBICHEBI:62088
EC No.256-627-7
DTXSIDDTXSID6044143

화학 및 물리적 성질

XLogP0
극성 표면적89.5
수소 결합 공여자 수1
수소 결합 수용자 수6
회전 가능 결합 수4
무거운 원자 수21
형식 전하0
복잡도546
의약품Pharmaceuticals -> Used in SwitzerlandPharmaceuticals -> Listed in ZINC15
Human DrugsBreast FeedingLactationMilk, HumanAnalgesic AgentsAnti-inflammatory Agents, NonsteroidalPharmaceuticals
Collision Cross Section173.9 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Dataset: TOXCASTSource Identifier: DTXSID10110043]
밀도1.46±0.1 g/cm3(Predicted)
녹는점131-132 °C (decomp)
pKa(산도 계수)1.32±0.50(Predicted)

안전 및 규제

HepatotoxicityCases of liver injury from metamizole were rarely reported before 2019 when two case series of liver injury from its use including fatalities were reported from Germany. Reassessments were conducted by the European Medicines Agency based upon accumulation of more than 40 cases. Within a year or two, reviews of more than 50 cases of clinically apparent liver injury due to metamizole were described. The clinical features of metamizole-associated liver injury have varied greatly, some being hyper-acute with rapid onset of fever, rash, and jaundice after the initial or first several doses. These cases may represent hypersensitivity reactions such as hepatic involvement in DRESS syndrome, toxic epidermal necrolysis, or Stevens-Johnson syndrome.
Drug Induced Liver InjuryDrug-Induced Liver Injury Severity and Toxicity (DILIst)METAMIZOLEDILI PositiveDOI:10.1016/j.drudis.2019.09.022
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation