염화 벤질디메틸옥타데실암모늄

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

3.8 [mg/m3]

41 [mg/m3]

250 [mg/m3]

Goggles or face shield; rubber gloves (USCG, 1999)

GOGGLES OR FACE SHIELD; RUBBER GLOVES.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3X10+7(SRC), determined from a structure estimation method(2), indicates that benzyldimethylstearylammonium chloride is expected to be immobile in soil(SRC). Volatilization of benzyldimethylstearylammonium chloride from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.2X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Benzyldimethylstearylammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-13 mm Hg(SRC), determined from a fragment constant method(4).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3X10+7(SRC), determined from an estimation method(2), indicates that benzyldimethylstearylammonium chloride is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.2X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 71(SRC), from its log Kow of 3.23(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is moderate. Using the SCAS method and the OECD Confirmatory test, 94 and 95% benzyldimethylstearylammonium chloride was degraded, respectively(8), suggesting that biodegradability in water is likely to be important(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzyldimethylstearylammonium chloride, which has an estimated vapor pressure of 1.2X10-13 mm Hg at 25 °C(SRC), using a fragment constant estimation method(2), is expected to exist in the particulate phase in the ambient atmosphere. Particulate-phase benzyldimethylstearylammonium chloride may be removed from the air by wet and dry deposition(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for benzyldimethylstearylammonium chloride can be estimated to be 3X10+7(SRC). According to a classification scheme(2), this estimated Koc value suggests that benzyldimethylstearylammonium chloride is expected to be immobile in soil.

SYMPTOMATOLOGY: 1. INGESTION OF CONCN SOLN LEADS TO IMMEDIATE BURNING PAIN IN MOUTH, THROAT, & ABDOMEN. PROFUSE SALIVATION. 2. HYPOTENSION...SIGNS & SYMPTOMS OF CIRCULATORY SHOCK. 3. ...APPREHENSION, RESTLESSNESS, CONFUSION, & WEAKNESS. /BENZALKONIUM CHLORIDE/

SYMPTOMATOLOGY /AFTER INGESTION OF CONCENTRATED SOLUTION/: 4. ...MUSCLE WEAKNESS...ASSOCIATED WITH...MUSCLE FASCICULATION... 5. CNS DEPRESSION...WEAK CONVULSIVE MOVEMENTS... MAY OR MAY NOT BE DUE TO CEREBRAL ISCHEMIA. 6. LABORED BREATHING & CYANOSIS DUE TO WEAKNESS OF RESP MUSCLES OR TO CIRCULATORY SHOCK. /BENZALKONIUM CHLORIDE/

SYMPTOMATOLOGY /AFTER INGESTION OF CONCENTRATED SOLUTION/: 7. ASPHYXIAL DEATH...TERMINAL CONVULSION, DUE TO PARALYSIS OF MUSCLES OF RESP OR TO CARDIOVASCULAR COLLAPSE. ...DEATH IS EXPECTED...WITHIN 1 OR 2 HR AFTER INGESTION. 8. IF PATIENT SURVIVES A PERIOD OF SEVERE HYPOTENSION, RENAL FAILURE MAY DEVELOP. /BENZALKONIUM CHLORIDE/

INGESTION CAUSES GASTROINTESTINAL DISTURBANCES. CONTACT WITH CHEM IRRITATES EYES & SKIN & MAY DAMAGE EYES.

Poison by intraperitoneal route. Moderately toxic by ingestion. A human skin irritant and severe experimental eye irritant.

Benzyldimethylstearylammonium chloride's production and use in contraceptive formulations(1), in industrial and institutional cleaners, various detergents, emulsion polymerization process, and paper and textile processing(2) may result in its release to the environment through various waste streams(SRC).

An estimated BCF of 71 was calculated for benzyldimethylstearylammonium chloride(SRC), using a log Kow of 3.23(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

The Henry's Law constant for benzyldimethylstearylammonium chloride is estimated as 4.2X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that benzyldimethylstearylammonium chloride is expected to be essentially nonvolatile from water surfaces(2). Benzyldimethylstearylammonium chloride's estimated Henry's Law constant(1) indicates that volatilization from moist soil surfaces will not occur(SRC). Benzyldimethylstearylammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon a an estimated vapor pressure of 1.2X10-13 mm Hg(SRC), determined from a fragment constant method(3).

BENZYLDIMETHYLSTEARYLAMMONIUM CHLORIDE DID NOT EXERT ANY SELECTIVE EMBRYOPATHIC ACTIVITY WHEN APPLIED TOPICALLY TO PREGNANT RATS DURING THE ORGANOGENIC PERIOD (DAYS 6-15 OF GESTATION) AT DOSAGE REGIMENS ELICITING ADVERSE MATERNAL REACTIONS (LOCAL SKIN REACTIONS).

CAPILLARY PERMEABILITY IN RABBIT AND MOUSE WAS INCREASED WHEN DODECYLDIMETHYLBENZYLAMMONIUM CHLORIDE WAS INTRACUTANEOUSLY INJECTED. THE PERMEABILITY THRESHOLDS WERE 0.01% AND 0.005% WHEN INJECTED INTO RABBIT AND MOUSE, RESPECTIVELY. THE PERMEABILITY THRESHOLD INCREASED 100-200-FOLD IN THE PRESENCE OF A KERATINOUS LAYER.

Benzyldimethylstearylammonium chloride is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum (>290 nm).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 25,059 workers (15,638 of these are female) are potentially exposed to benzyldimethylstearylammonium chloride in the US(1). Occupational exposure to benzyldimethylstearylammonium chloride may occur via dermal contact with this compound at workplaces where benzyldimethylstearylammonium chloride is produced or used(SRC). The general population may be exposed to benzyldimethylstearylammonium chloride by using consumer products containing benzyldimethylstearylammonium chloride(SRC).

The food additive, quaternary ammonium chloride combination, may be safely used in food in accordance with the following conditions: (a) The additive contains the following compounds: ... n-octadecyl dimethyl benzyl ammonium chloride ... (b) The additive meets the following specifications: pH (5% active solution) 7.0-8.0; total amines, maximum 1% as combined free amines and amine hydrochlorides. (c) The additive is used as an antimicrobial agent, as defined in 170.3(o)(2) of this chapter, in raw sugar cane juice. It is added prior to clarification when further processing of the sugar cane must be delayed. (d) The additive is applied to the sugar juice in the following quantities, based on the weight of the raw sugar: ... n-octadecyl dimethyl benzyl ammonium chloride 0.25-1.0 ppm ... .