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HCID 31272생성일: 2026년 10월 27일

아세트산부틸

아세트산부틸 · n-부틸아세트산 · n-뷰틸아세트산 · 부틸에탄산 · 뷰틸아세트산 · 초산부틸 · 초산n-부틸 · 부틸아세테이트

https://huagongshe.com/ko/chemical/31272

아세트산부틸 분자 구조식

식별자 및 물리적 특성

CAS No.123-86-4
분자식C6H12O2
평균 분자량116.16 g/mol
단동위원소 질량116.08372962 g/mol
SMILESCCCCOC(C)=O
InChIKeyDKPFZGUDAPQIHT-UHFFFAOYSA-N
PubChem CID31272
ChEMBLCHEMBL284391
ChEBICHEBI:31328
EC No.204-658-1
DTXSIDDTXSID3021982
현지명아세트산부틸

화학 및 물리적 성질

XLogP1.8
극성 표면적26.3
수소 결합 공여자 수0
수소 결합 수용자 수2
회전 가능 결합 수4
무거운 원자 수8
형식 전하0
복잡도68
LogP(분배 계수)log Kow = 1.781.82
냄새Strong fruity odorSweet특성기분 좋은 과일향(낮은 농도)비잔류.
맛Burning and then sweet taste reminiscent of pineapplePleasant, banana-like taste
밀도0.875 at 68 °F (USCG, 1999) - Less dense than waterwill float0.8825 g/cu cm at 20 °CRelative density (water = 1): 0.880.876-0.8800.88 @25 °C0.88 g/mL at 25 °C (lit.)
Viscosity1.002 mPa.s at 0 °C0.685 mPa s at 25 °C0.500 mPa.s at 50 °C0.383 mPa.s at 75 °C0.305 mPa.s at 100 °C
Color/FormColorless liquid
용해도1 to 5 mg/mL at 68 °F (NTP, 1992)In water, 8.33X10+3 mg/L at 25 °CIn water, 6,700 ppm at 25 °CSoluble in 120 parts water at 25 °CIn water, 14,000 mg/L at 20 °C5,000 mg/L at 25 °CFor more Solubility (Complete) data for n-Butyl acetate (7 total), please visit the HSDB record page.5.3g/L
인화점72 °F (NTP, 1992)22 °C72 °F (22 °C) (Closed cup)22 °C c.c.74 °F
끓는 점259.7 °F at 760 mmHg (NTP, 1992)126.0 °C126.10 °C. @ 760.00 mm Hg126 °C125-126 °C258 °F124-126 °C (lit.)
DecompositionWhen heated to decomp it emits acrid smoke and irritating fumes.
녹는점-108.2 °F (NTP, 1992)-77 °C-78 °C-107 °F-78 °C (lit.)
증기 밀도4 (NTP, 1992) - Heavier than airwill sink (Relative to Air)4.0 (Air = 1)Relative vapor density (air = 1): 4.04 (vs air)
증기압15 mm Hg ( 25 °C)
굴절률n20/D 1.394(lit.)
FEMA2174 | BUTYL ACETATE
저장 조건Store at +5°C to +30°C.
물리적 상태액체
색상≤10(APHA)
비중0.883 (20/20℃)
pH6.2 (5.3g/l, H2O, 20℃)(External MSDS)
폭발한계1.4-7.5%(V)
후각 역치0.016ppm
향취 유형미묘한
생물학적 소스synthetic
용해도0.7g/100mL(20℃)
비열Cp(liquid): 1.96 J/(g·K), at 25℃
JECFA Number127
Merck14,1535
BRN1741921
헨리 상수5.79 at 37 °C (static headspace-GC, van Ruth et al., 2001)
유전율5.0(20℃)
안정성안정적인. 가연성. 강한 산화제, 강산, 강염기와 호환되지 않습니다.
화장품 원료 기능향기용제
InChI1S/C6H12O2/c1-3-4-5-8-6(2)7/h3-5H2,1-2H3
InChIKeyDKPFZGUDAPQIHT-UHFFFAOYSA-N
SMILESCCCCOC(C)=O
LogP(분배 계수)1.82-2.3 at 25℃
표면장력24.85mN/m at 298.15K
NISTAcetic acid, butyl ester(123-86-4)
EPAn-Butyl acetate (123-86-4)

화학적 성질

Butyl acetate is a colorless or yellowish liquid with a strong fruity odor. burning and then sweet taste reminiscent of pineapple. It occurs in many fruits and is a constituent of apple aromas. Butyl acetate is incompatible with strong oxidizing agents, strong acids, and strong bases. There are 4 isomers. At 20 °C, the density of the n-butyl isomer is 0.8825 g/ cm3, and the density of the sec-isomer is 0.8758 g/cm3 (Bisesi, 1994). The n-butyl isomer is soluble in most hydrocarbons and acetone, and it is miscible with ethanol, ethyl ether, and chloroform (Haynes, 2010). It dissolves many plastics and resins (NIOSH, 1981).

안전 및 규제

GHS 분류WarningH226: Flammable liquid and vapor [Warning Flammable liquids]H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposureNarcotic effects]P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.3% (12 of 4374) of reports.
규제 정보Chemical: Acetic acid, butyl esterRegulation (EC) No 178/2002 (amended)Acetic acid, butyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, butyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15948Status: Active Update: 05-02-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/27693Status: No longer Valid Update: 11-01-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/6316Acetic acid, butyl ester: HSNO Approval: HSR001091 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보IMAP assessments - Acetate esters (C2-C4): Human health tier II assessmentIMAP assessments - Acetic acid, butyl ester: Environment tier I assessment
운송 라벨(DOT)Flammable Liquid
화재 위험Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)

용도

용도

1. 액체 부틸 아세테이트 (Liquid Butyl Acetate) 는 니트로 셀룰로오스 니스에 널리 사용되는 우수한 유기 용제이며 인조 가죽, 직물 및 플라스틱 가공, 향수 업계에도 사용됨. 2. GB 2760 96 규정에서 액체 부틸 아세테이트 는 향료를 사용하기위한 것이다. 3. 액체 부틸 아세테이트 가 과일 풍미에서 사용 되더라도, 주요로는 확산의 좋은 성능을 취하고, 사용하기에 더 적합합니다. 4. 부틸 아세테이트 는 우수한 유기 용제, 셀룰로스 아세테이트 부티레이트, 에틸 셀룰로오스, 염화 고무, 폴리스티렌, 메타 크릴 수지 및 껌, 마닐라 고무, 댐코 (Damco) 수지 등과 같은 많은 천연 수지가 양호한 용해도를 나타냅니다. 인조 가죽, 직물 및 플라스틱의 가공에서 용제로서 니트로 셀룰로오스 바니쉬에 널리 사용되며, 다양한 석유 가공 및 제약 공정 에서뿐만 아니라 향신료와 살구, 바나나, 배, 파인애플 등의 합성. 다양한 방향 성분. 5. 부틸 아세테이트 는 껌 로진, 폴리 비닐 아세테이트, 폴리 아크릴 레이트, 폴리 비닐 클로라이드, 염화 고무, 폴리 염화 비닐, 바니시, 인조 가죽, 의약, 플라스틱 및 향수 산업, (Eucommia gum), 폴리 메틸 메타 크릴 레이트 (polymethyl methacrylate) 등이있다. 6. 부틸 아세테이트 는 분석 시약, 크로마토 그래피 표준 물질 및 용매로 사용됩니다.

용도

아세트산 n- 부틸은 쾌적한 과일 냄새가 나는 무색의 인화성 액체입니다. n- 부틸 아세테이트의 가장 일반적인 용도는 래커와 도료의 제조시 용매로 사용됩니다. 그것의 다른 주요 용도는 접착제 및 경화 된 코팅의 생성에 있습니다. 일반 부틸 아세테이트는 또한 제약 산업에서 용매 또는 추출 제로서 사용된다.

용도

n- 부틸 아세테이트의 가장 보편적 인 사용은 래커와 도료의 생산에서 용매로서 사용됩니다. 그것의 다른 주요 용도는 접착제 및 경화 된 코팅의 생성에 있습니다. 일반 부틸 아세테이트는 또한 제약 산업에서 용매 또는 추출 제로서 사용된다.

개요

Butyl acetate is a clear, flammable ester of acetic acid that occurs in n-, sec-, and tert- forms (INCHEM, 2005). Butyl acetate isomers have a fruity, banana-like odor (Furia, 1980). Isomers of butyl acetate are found in apples (Nicholas, 1973) and other fruits (Bisesi, 1994), as a well as in a number of food products, such as cheese, coffee, beer, roasted nuts, vinegar (Maarse and Visscher, 1989). Butyl acetate is manufactured via esterification of the respective alcohol with acetic acid or acetic anhydride (Bisesi, 1994). N-butyl acetate is used as a solvent for nitrocellulose-based lacquers, inks, and adhesives. Other uses include manufacture of artificial leathers, photographic film, safety glass, and plastics (Budavari, 1996). Isomers of butyl acetate are also used as flavoring agents, in manicure products, and as larvicides (Bisesi, 1994). The tert-isomer has been used as a gasoline additive (Budavari, 1996). It may be used as a synthetic fruit flavoring in candy, ice cream, cheeses, and baked goods (Dikshith, 2013).

출처

Reported present in rum ether, pears, pear brandy, cider, mango, mountain papaya (C. pubescens), soybean, roasted peanuts and honey and other natural products.

용도

Butyl Acetate is a flavoring agent which is a clear, colorless liquid possessing a fruity and strong odor. it is sparingly soluble in water and miscible in alcohol, ether, and propylene glycol. it is also termed n-butyl acetate.

제조 및 합성 방법

생산 방법

Butyl alcohol is combined with acetic acid in the presence of a catalyst such as sulfuric acid. After esterification is complete, the solution is distilled to yield butyl acetate .

제조 방법

By esterification of n-butyl alcohol with acetic acid.

Flammable. Above 22 °C explosive vapour/air mixtures may be formed.
화재 가능성Flammable liquid.
건강 유해성SKIN: prolonged or frequently repeated exposures may lead to drying. INHALATION: headaches, dizziness, nausea, irritation of respiratory passages and eyes. (USCG, 1999)
유해성 요약Narcosis induced in acute animal studiesIn animal experiments, causes liver injury in doses greater than 500 mg/kg[ACGIH] A skin, eye, and respiratory tract irritantInhalation of high concentrations can cause CNS depression[ICSC]
운송 번호 및 가이드(DOT)1123 129
FDA 요건Butyl acetate is an indirect food additive for use only as a component of adhesives.Butyl acetate is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.
반응성 그룹Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
EC 분류R: 10-66-67S: (2)-25Note: 6
UN 분류UN Hazard Class: 3UN Pack Group: II
소화Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842).LARGE FIRE: Water spray, fog or alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzlesif this is impossible, withdraw from area and let fire burn. (ERG, 2024)Use AFFF, alcohol-resistant foam, dry powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
응급 조치Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
안전 보관Fireproof. Separated from strong oxidants, strong bases and strong acids. Cool.
Firefighting HazardsHazardous decomposition products formed under fire conditions: Carbon oxides.Its vapors are heavier than air.
노출 관리 및 개인 보호100.0 [ppm]
소화 절차Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.If material on fire or involved in a fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Butyl acetates/
보관 조건Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
정리 방법ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Apply appropriate foam to diminish vapor and fire hazard. /Butyl acetates/Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Use surface active agent (eg detergent, soaps, alcohols), if approved by EPA. Inject "universal" gelling agent to solidify encircled spill and increased effectiveness of booms. If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Butyl acetates/Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Butyl acetates/The waste waters from the production of antibiotics contain certain quantities of butyl acetate or butanol. For the purpose of their purification by removal of these organic solvents a technology and an installation have been created. The installation described operates steadily with waters tending to cause settling of solids, when heated in a heat exchanger or when decreasing the concentration of the organic solvent in the stripping column. The investigation of the industrial column shows a degree of purification of 99-100% at different regimes of operation. The five year exploitation of the installation for removal of butyl acetate and the two year operation of that for the removal of butanol showed that the solids coagulating from waste water did not settle on the apparatus walls.
비화재 누출 대응Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)
처리 방법SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
누출 처리Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable metal or glass containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
체내 부담n-Butyl acetate was detected in the expired breath of 3 of 8 human subjects at an expiration rate of 8.7-41.0 ug/hr(1). n-Butyl acetate was detected in 31 % of 387 expired air samples collected from 54 human volunteers at a mean concentration of 0.2 ng/L(2).
상호 작용The effects of combined exposure to n-butyl alcohol and n-butyl acetate on rotarod performance and hot plate behavior in rats and respiratory rate in mice were investigated in the condition of an acute inhalation experiment. Rotarod performance and hot-plate behavior were tested in rats exposed to various concentrations of n-butyl alcohol, n-butyl acetate and their mixture consisting of 50 vol-% n-butyl alcohol and 50 vol-% n-butyl acetate immediately after termination of a 4 hr exposure period. The respiratory rate in mice was recorded continuously before the exposure to solvents, during 6 min of exposure and 6 min after termination of exposure using whole body plethysmographic method. Mice were exposed to vapors of single solvents and their 50:50 vol-% mixture. Both solvents and their mixture caused concentration-dependent disturbances of rotarod performance in rat. The medial effective concentration (EC50) for the effect amounted to 7559 ppm, 8339 ppm, and 10,672 ppm for n-butyl alcohol, n-butyl acetate and their mixture, respectively. Both solvents and their mixture decreased sensitivity to the pain and changes were concentration -dependent. In condition of combined exposure the results obtained in rotarod and hot-plate behavior test indicate the summation of individual solvent effects. The tested solvents resulted in concentration-dependent decrease in respiratory rate in mice. n-Butyl alcohol produced maximal decrease in respiratory rate in the first minute of exposure whereas n-butyl acetate in the sixth minute.Adult female SPF rats (strain: Sprague-Dawley) were treated with 790 mg ethanol/kg body weight by intraperitoneal injection 30 minutes after the beginning of a 5-hr-inhalation of about 1,000 ppm n-butyl acetate in air via a tracheotomy tube (under urethane anesthesia). The elimination of the ethanol from blood which was increased to about 24 mmol/L (1.1%, g/v) was not delayed during the initial linear phase as compared to control (ethanol treatment without inhalation of n-butyl acetate). During inhalation approximately 24 mumol n-butyl acetate/L were measured in blood without ethanol treatment and approximately 52 mumol n-butanol/L as a metabolite of n-butyl acetate. The n-butanol content in blood was doubled under ethanol treatment. This increase is explained by substrate competition of both alcohols at the alcohol dehydrogenase with ethanol excess.... The developmental toxic potential ... was examined in Sprague-Dawley rats following whole body inhalation exposure, 6 hr /per/ day, from day 6 to 20 of gestation. ... The developmental toxic effects of simultaneous exposures to ethylbenzene (EB) and /n-butyl acetate/ BA, or to toluene (TOL) and BA were evaluated. Pregnant rats were administered EB (0, 250 or 1000 ppm) and BA (0, 500 or 1500 ppm), or TOL (0, 500 or 1500 ppm) and BA (0, 500, 1500 ppm), separately and in combinations, using a 2 x 2 factorial design. The maternal weight gain was reduced after exposure to 1000 ppm EB, to 1500 ppm BA, or to 1500 ppm TOL, either alone or in binary combinations. A significant reduction of fetal weight was associated with exposure to 1000 ppm EB alone, to either mixtures of EB with BA, or to 1500 ppm TOL alone or combined with BA at either concentration. No embryolethal or teratogenic effects were observed whatever the exposure. There was no evidence of interaction between EB and BA or between TOL and BA in causing maternal or developmental effects.
표적 장기Eyes, skin, respiratory system, central nervous system
생태독성 수치LC50Species: Chlorococcales (Green Algae Order)Conditions: freshwater, staticConcentration: 1200000 ug/L for 24 hr /formulation/Species: Daphnia magna (Water Flea) age < or =24 hrConditions: freshwater, static, 20-22 °CConcentration: 205000 ug/L for 24 hr /formulation/Species: Lepomis macrochirus (Bluegill)Conditions: static bioassay in fresh water, mild aeration applied after 24 hr, 23 °CConcentration: 100 ppm for 96 hrSpecies: Menidia beryllina (Inland silverside)Conditions: static bioassay in synthetic seawater, mild aeration applied after 24 hr, 23 °CConcentration: 185 ppm for 96 hrFor more Ecotoxicity Values (Complete) data for n-Butyl acetate (12 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 19(SRC), determined from a structure estimation method(2), indicates that n-butyl acetate is expected to have very high mobility in soil(SRC). Volatilization of n-butyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 2.81X10-4 atm-cu m/mole(3). n-Butyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 11.5 mm Hg at 25 °C(4). Using a standard BOD dilution technique and a sewage inoculum, theoretical BODs of 56% to 86% were observed during 5 and 20 day incubation periods(5), suggesting that n-butyl acetate may biodegrade in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 19(SRC), determined from a structure estimation method(2), indicates that n-butyl acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 2.81X10-4 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6.5 hours and 5.3 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 7(SRC), from its log Kow of 1.78(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis may be an important environmental fate for this compound based upon experimentally determined hydrolysis half-lives of 2 yrs and 78 days at pH 7 and 8, respectively(2). Using river water as seed, 5-day and 20-day theoretical BODs of 20.9% and 55.4%, respectively, were measured(7), suggesting that biodegradation may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butyl acetate, which has a vapor pressure of 11.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase n-butyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.2 days(SRC), calculated from its rate constant of 4.9X10-12 cu cm/molecule-sec at 25 °C(3). n-Butyl acetate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
식품 조사 수치n-Butyl acetate has been detected as a volatile flavor component of baked potatoes(1) and roasted filbert nuts(2). It has been identified as a naturally occurring flavor and fragrance component of apples(3). n-Butyl acetate has been identified in cheese volatiles(4), apricots and plumbs(5), dalieb fruit(6), apples(7,8), volatiles of chickpea seeds(9) and nectarines(10). n-Butyl acetate was not detected in scrambled eggs made from supermarket purchased, fresh unstored or fresh stored eggs(11).
유해 작용Neurotoxin - Acute solvent syndromeOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
노출 경로The substance can be absorbed into the body by inhalation of its vapour.inhalation, ingestion, skin and/or eye contact
독성 요약Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIDENTIFICATION AND USE: n-Butyl acetate is a colorless liquid. It is used in manufacture of lacquer, artificial leather, photographic films, plastics, and safety glass. It is also used as an organic solvent and synthetic flavoring ingredient. HUMAN STUDIES: Male and female volunteers were exposed to different concentrations of n-butyl acetate vapor for 2 to 5 minutes. With exposure at 200 ppm for 3 to 5 minutes, the majority of the subjects complained of throat irritationat 300 ppm for 3 to 5 minutes, the majority reported eye and nose irritation and severe throat irritation. In cases of severe overexposure, weakness, drowsiness, and unconsciousness have been seen. Chronic exposure to n-butyl acetate in humans has been associated with mild skin irritation. Repeated contact of the skin with the liquid may lead to defatting and cracking. Workers exposed chronically to n-butyl acetate have reported conjunctival irritation, feeling of chest constriction, and coughing. However, permanent lesions of the eyes and respiratory tract and other systemic effects have been reported in an occupational setting only when n-butyl acetate is present in a mixture with other solvents, and these effects appear to be due to the other solvents. ANIMAL STUDIES: n-Butyl acetate showed no sensitization potential when tested in a maximization test using guinea-pigs. Following 24 hr application of 0.01 mL of the neat material to the clipped skin of five albino rabbits, n-butyl acetate was slightly irritating. Guinea pigs exposed for 1 to 810 minutes at vapor concentration of 0.33, 0.7, or 1.4% by volume of n-butyl acetate were examined. At 0.33%, only eye irritation occurred. Irritation of the nose and eyes, lacrimation, incoordination, CNS depression, and respiratory disturbances were noted at the two higher concentration. Deaths were recorded only at the 1.4% concentration after 4 hours and occurred during exposureslight to moderate congestion of the brain, lungs, and kidneys were noted.
Plant ConcentrationsButyl acetate has been identified as a naturally occurring component of apples(1). Butyl acetate was reported in the skin and pulp of Queen Anne's pocket melon (Cucumis melo L) at 123.9 and 110.5 ug/kg, respectively(2). n-Butyl acetate was detected in the head space of golden delicious apples 1, 5, 8, 12, 14, 16, 19 and 22 days after harvesting at concentrations of 0.53, 1.73, 15.35, 64.97, 81.45, 78.25, 79.41 and 71.12 ug/6 L head space, respectively(3). n-Butyl acetate was detected as a volatile component of Miyabi variety of Japanese muskmelon(4).n-Butyl acetate occurrence in plants(1).[Table#503]
Signs and SymptomsCough. Sore throat. Dizziness. Headache.Dry skin.Redness. Pain.Nausea.irritation eyes, skin, upper respiratory systemheadache, drowsiness, narcosis
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for n-butyl acetate is available.[Available from, as of March 27, 2018: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of March 27, 2018: http://actor.epa.gov/dashboard/]
TSCA 요건A testing consent order is in effect for n-butyl acetate for health effects testing. FR citation: 1/23/95.
대기 기준This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. n-Butyl acetate is produced, as an intermediate or final product, by process units covered under this subpart.
CERCLA 보고 수량Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).
청정수법 요건Butyl acetate is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.
주 식수 지침(FL) FLORIDA 2,500 ug/L
직업 노출 등급(OEB)A
직업 노출 한계(OEL)TWA: 150 ppm (710 mg/m3), STEL: 200 ppm (950 mg/m3)
수질 위해 등급(WGK)1
즉시 생명 위험 농도1,700 ppm
TSCA 등재 상태TSCA listed
RTECS 번호AF7350000
운송 번호(UN)UN 1123 3/PG II/III (BUTYL ACETATES)
독성LD50 orally in rats: 14.13 g/kg (Smyth)
관세 코드2915 33 00
위험 문구(R)10-66-67-R67-R66-R10
안전 문구(S)25-S25
포장분류III
위험 등급3Flam. Liq. 3STOT SE 3
기존화학 물질KE-04179
자연 발화 온도790 °F
저장 분류3 - Flammable liquids
유해 물질 데이터123-86-4(Hazardous Substances Data)

일반 설명

A clear colorless liquid with a fruity odor. Flash point 72 - 88°F. Density 7.4 lb / gal (less than water). Hence floats on water. Vapors heavier than air.