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과산화 요소

Carbamide Peroxide

HCID 31294
새 노트새 반응견적 요청하기
인쇄 미리보기
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
124-43-6
표준 SMILES
NC(N)=O.OO
InChIKey
AQLJVWUFPCUVLO-UHFFFAOYSA-N
분자식
CH4N2O.H2O2
평균 분자량
94.07 g/mol
단동위원소 질량
94.03784206

개요

Urea hydrogen peroxide appears as a solid or paste-like semisolid. Used to make plastics.

이름 및 식별자

우선 이름
Carbamide Peroxide
IUPAC
hydrogen peroxide;urea
현지명
과산화 요소
영어명
Urea hydrogen peroxide
분자식
CH6N2O3
분자량
94.07

이름 및 동의어

CARBAMIDE PEROXIDEUrea hydrogen peroxide124-43-6PercarbamideUrea peroxideUrea dioxideUrea hydroperoxideHydroperitHydroperitePercarbamidHyperolOrtizon
이름 더 보기
과산화요소과산화우레아과산화우레아우레아퍼옥사이드카바아미드퍼옥사이드과산화 우레아요소과산화물UHPUREA HYDROGEN PEROXIDE ADDUCTUREA HYDROGEN PEROXIDE ADDITION COMPOUND
PerhydritThenardolPerhydrol-UreaHydrogen peroxide ureaHydrogen peroxide carbamideMurine Ear DropsDebroxGly-oxide

데이터베이스 식별자

CAS
124-43-6、14479-85-7
PubChem CID
31294
DTXSID
DTXSID9024726
ChEMBL
CHEMBL3184026
ChEBI
CHEBI:75178
UNII
31PZ2VAU81
EC Number
204-701-4

물성

구조 계산 물성

극성 표면적
110 Ų
수소 결합 공여자 수
4
수소 결합 수용자 수
3
회전 가능 결합 수
0
무거운 원자 수
6
형식 전하
0
복잡도
29

실험 및 물리화학적 성질

Chemical ClassesOther Classes -> Peroxides, Organic
CosmeticsOxidising
Density · 2건

0.8 at 68 °F (USCG, 1999) - Less dense than water; will float

0.8 @ 20°C

Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Human DrugsBreast Feeding; Lactation; Peroxides
Melting Point · 2건

167 to 185 °F (decomposes) (NTP, 1992)

75-85

Physical Description · 2건

Urea hydrogen peroxide appears as a solid or paste-like semisolid. Used to make plastics.

White solid; [Merck Index] Solid or paste-like semisolid; [CAMEO] Odorless; [CHRIS] White tablet; [Sigma-Aldrich MSDS]

Autoignition Temperaturegreater than 680 °F (USCG, 1999)

물리화학적 성질

녹는점
90 · 90-93 °C (lit.)
끓는 점
175.5 °C · 175.5°C (rough estimate)

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 6건

Danger

H272 (94.9%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P260, P264, P264+P265, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P332+P317, P362+P364, P363, P370+P378, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 59 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

유해성 정보

Regulatory Information · 4건

Chemical: Urea, compound with hydrogen peroxide (H2O2) (1:1)

REACH registered substance: Hydrogen peroxide-urea (EC: 204-701-4)

Urea, compd. with hydrogen peroxide (1:1): HSNO Approval: HSR001360 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Other Safety InformationIMAP assessments - Urea, compound with hydrogen peroxide (H2O2) (1:1): Human health tier II assessment
DOT LabelOxidizer Corrosive
Fire Hazards · 2건

Special Hazards of Combustion Products: Irritating ammonia gas may be formed in fire.

CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112).

Health Hazards · 2건

Inhalation of dust causes irritation of nose from hydrogen peroxide formed when heated. Contact with eyes causes severe damage. Contact with moist skin causes temporary itching or burning sensation. Ingestion causes irritation of mouth and stomach. (USCG, 1999)

화학 및 산업

약리 정보

Protein BindingNo established pharmacokinetic data.
Pharmacodynamics · 1건

Carbamide peroxide releases hydrogen peroxide and free radicals upon contact with water or outer surfaces of ear and tooth. Hydrogen peroxide exerts cerumenolytic, enamel-bleaching and antiseptic actions. _In vitro_, the chemical stability of ceramics against bleaching agents was observed after treatment with 15% carbamide peroxide for 56 h, 16% carbamide peroxide for 126 h, 10% or 15% carbamide peroxide and 38% hydrogen peroxide for 30 minutes or 45 minutes, respectively. According to _in vitro_ studies, high (37%) or low (10 or 16%) concentrated carbamide peroxide agents were similarly effective as oral bleaching agents. Treatment with carbamide peroxide may lead to demineralization which involves decreased mineral content of enamel calcium, phosphate, and fluoride, and alteration of the chemical, structural, and mechanical properties. Carbamide peroxide may affect the organic components of the enamel and lead to increased susceptibility to erosion, fracture stability or decreased abrasion resistance of the treated area.

Mechanism of Action · 1건

Carbamide peroxide release hydrogen peroxide upon contact with teeth, which is a strong oxidizing and bleaching agent. It also release free radicals such as H+ or H3O+. Hydrogen peroxide also acts as an antiseptic, especially in sites with relative anaerobiosis. Following otic administration, carbamide peroxide complex releases hydrogen peroxide that breaks up the hardened wax. The hydrogen peroxide component, which further breaks down into water, is also a cerumenolytic that hydrates the desquamated sheets of corneocytes, which are the major constituent of cerumen plugs. The glycerol and urea facilitates softening of the cerumen, either with or without syringing. Both hydrogen peroxide and urea mildly induce keratolysis with disintegration of the ear wax to help reduce the keratin-load in the ear debris and allow other active components to reach the skin under the debris.

Biological Half-LifeNo established pharmacokinetic data.
Metabolism/MetabolitesNo established pharmacokinetic data.

관련 반응

152건
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화합물 노트

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더보기
새 노트새 반응견적 요청하기
증기압
23.3 mm · 23.3 mm Hg ( 30 °C)
굴절률
1.4616 · 1.4616 (estimate)
저장 조건
15 °C · Store at +15°C to +25°C.
용해도
2 O: · H2O: 0.5 g/mL, 투명하거나 매우 희미하게 흐릿함
물리적 상태
플레이크 크리스탈
색상
하얀색
수소이온지수(pH)
6.3 · 6.3 (H2O, 20℃)
수용성
500 g/L · 500g/L(20℃)
Merck
14 · 14,1782
BRN
3680414 · 3680414
안정성
불안정한. 산화제. 충격이나 열에 노출되면 심각한 폭발 위험이 있습니다. 강산화제, 유기물질, 환원제, 미세분말 금속과 혼합할 수 없습니다. 에테르나 프로판온과 함께 폭발성 용액을 형성할 수 있습니다.
화장품 원료 기능
산화
InChI
1S/CH4N2O.H2O2/c2-1(3)4;1-2/h(H4,2,3,4);1-2H
InChIKey
AQLJVWUFPCUVLO-UHFFFAOYSA-N
SMILES
OO.NC(N)=O
LogP
0.09 at · 0.09 at 25℃
EPA
Carbamide peroxide (124-43-6)
화학적 성질 · 1건

White crystals or crystalline powder. Decomposed by moisture at temperatures around 40C. Soluble in water, alcohol, and ethylene glycol; solvents such as ether and acetone extract hydrogen peroxide and may form explosive solutions. Active oxygen (min) 16%

· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death.

Hazards Summary · 1건

Decomposed by air into urea, oxygen, and water; [Merck Index] A strong oxidizer that may combust on heating or on contact with organic substances; [CAMEO] Forms hydrogen peroxide solution on contact with water; An irritant that may cause severe eye injury; [CHRIS] Serious explosion hazard from shock or heat; An irritant that may cause corneal damage and skin blistering; [NTP] An oxidizer that may intensify fire; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Sigma-Aldrich MSDS] See Hydrogen peroxide.

DOT ID and Guide1511 140
Reactive GroupAmides and Imides
Reactivity AlertsStrong Oxidizing Agent
Reactivity Profile · 1건

UREA HYDROGEN PEROXIDE is an oxidizing agent. Liable to spontaneous combustion when heated or in contact with organic materials. The contents of a screw-capped brown glass bottle spontaneously erupted after four years storage at ambient temperature. [MCA Case History No. 719]. Combustion may release Irritating ammonia gas.

DOT Hazard Classification · 5건

Urea hydrogen peroxide

UN1511

Div 5.1 Oxidizer (49 eCFR § 173.127)

Div 5.1 Oxidizer (49 eCFR § 173.127)

PG III: the degree of danger presented by the material is minor

Air and Water ReactionsDecomposed by moisture at about 40 °C to yield a solution of hydrogen peroxide (nonhazardous reaction). Water soluble.

안전 및 보호

Fire FightingExcerpt from ERG Guide 140 [Oxidizers]:
Accidental Release Measures · 2건

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

First Aid · 2건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).
Nonfire Spill ResponseExcerpt from ERG Guide 140 [Oxidizers]:
Isolation and Evacuation · 2건

Excerpt from ERG Guide 140 [Oxidizers]:

Immediate precautionary measure

Protective Action Criteria (PAC) · 3건

1.2 [mg/m3]

13 [mg/m3]

79 [mg/m3]

Personal Protective Equipment (PPE)Rubber gloves and protective goggles (USCG, 1999)
Emergency Response Planning GuidelinesSmall Fire

독성 정보

Adverse EffectsDermatotoxin - Skin burns.
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

wgk
2
tsca
TSCA listed
ridadr
UN 1511
독성
LD50 orally in Rabbit: > 2000 mg/kg
HS 번호
28470000
risk_code
8-34-36/37/38
hazard_code
Xi,C,O
safety_code
26-36-45-36/37/39-17
포장분류
III
위험 등급
5.1
기존화학 물질
KE-35147
F 고인화성물질
21
Hazard Classifications
Eye Dam. 1Ox. Sol. 3Skin Irrit. 2
스토리지 클래스
5.1B - Oxidizing hazardous materials
함량 및 규제정보
물질구분: 유독물질; 혼합물(제품)함량정보: 과산화 우레아 및 이를 17% 이상 함유한 혼합물
유해화학물질 필터링
97-1-3
MeSH Pharmacological Classification · 2건

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.

Chemicals that are used to oxidize pigments in TEETH and thus effect whitening.

Absorption, Distribution and Excretion · 4건

Upon treatment into the external auditory canal or the dental cavity, exposure to carbamide peroxide is limited to the intimate contact with the treated area without any systemic absorption.

No established pharmacokinetic data.

No established pharmacokinetic data.

No established pharmacokinetic data.

용도 및 제조

Uses · 2건

Used as an antiseptic, cerumenolytic, and dental bleach; [Merck Index] Used to make plastics; [CAMEO] Used for hair bleaching, oxidation of permanent waves, and hair relaxing; [ExPub: EC: SCCP] Used to develop blueprints and for the modification of starches; [NTP]

Using Disinfectants or Biocides [Category: Clean]

Household ProductsInformation on 1 consumer products that contain Urea Peroxide in the following categories is provided:
Use ClassificationCosmetics -> Oxidising
General Manufacturing InformationUrea, compd. with hydrogen peroxide (H2O2) (1:1): ACTIVE
응용 분야 · 2건

용도Urea hydrogen peroxide is an antiseptic, disinfectant and bleaching agent used in pharmaceuticals and cosmetics respectively. It is used in the whitening of teeth and relieves minor inflammation of gums, oral mucosal surfaces and lips. It finds application in the preparation of plastics, blue print development and starch modification. In addition to this, it is used as a source of hydrogen peroxide easily handled in the laboratory.

일반 설명A solid or paste-like semisolid. Used to make plastics.

상·하류 제품 정보

상류 원료

과산화 수소요소

하류 제품

디포스포릭 엑시드, 화합물 과 피페라진(1:1)인산 나트륨, 일염기, 모노수화물3-플루오로-4-니트로벤자미드Ferric pyrophosphate

추가 설명

정의ChEBI: A mixture obtained by combining equimolar amounts of hydrogen peroxide and urea.