기본 정보
- CAS
22760-18-5- 표준 SMILES
Cc1ccc2c(-c3ccccc3)nc(=O)n(C(C)C)c2c1- InChIKey
JTIGKVIOEQASGT-UHFFFAOYSA-N- 분자식
- C18H18N2O
- 평균 분자량
- 278.3 g/mol
- 단동위원소 질량
- 278.1419132
개요
Proquazone is a member of pyrimidines.
이름 및 식별자
- 우선 이름
- Proquazone
- IUPAC
- 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
- 현지명
- 프로쿠아존
- 영어명
- proquazone
- 분자식
- C18H18N2O
- 분자량
- 278.35
이름 및 동의어
PROQUAZONE22760-18-5ArthrexProquazonumProcuazona42VPJ2980SDTXSID4021210RefChem:8698751-isopropyl-4-phenyl-7-methyl-2-(1H)-quinazolineDTXCID801210M01AX13245-203-7
이름 더 보기
프로쿠아존43-715BiarsanSaH-43-715ProquazonaSandoz-43-715Proquazone, 10 mM in DMSO
7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-Biarison1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone7-methyl-4-phenyl-1-(propan-2-yl)-1,2-dihydroquinazolin-2-oneAnthrex; Biarison;RU 43-715; SAN 43-715
데이터베이스 식별자
- CAS
22760-18-5- PubChem CID
- 31508
- DTXSID
DTXSID4021210- ChEMBL
CHEMBL268501- ChEBI
CHEBI:135151- UNII
- 42VPJ2980S
- EC Number
- 245-203-7
- Nikkaji
- J11.480D
물성
구조 계산 물성
- XLogP
- 3
- 극성 표면적
- 32.7 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 423
실험 및 물리화학적 성질
Human DrugsPharmaceuticals
물리화학적 성질
- 녹는점
- 137 · 137-138°
- 끓는 점
- 436.12 °C · 436.12°C (rough estimate)
- 밀도
- 1.1707 · 1.1707 (rough estimate)
- 굴절률
- 1.57 · 1.5700 (estimate)
- 산도 계수 (pKa)
- 0.74 · 0.74±0.20(Predicted)
화학 및 산업
약리 정보
ATC Code
M - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
용도 및 제조
Use ClassificationPharmaceuticals
응용 분야
용도Proquazone is a non-steroidal anti-inflammatory drug.
공급사12 곳
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