독세핀

독세핀 · Doxepine · 3-(DIBENZO[B,E]OXEPIN-11(6H)-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE · Aponal · p3693a · Curatin · Docepin · P-3693A

https://huagongshe.com/ko/chemical/3158

식별자 및 물리적 특성

CAS No.	1668-19-5
분자식	C19H21NO
평균 분자량	279.4 g/mol
단동위원소 질량	279.16231429 g/mol
SMILES	CN(C)CCC=C1c2ccccc2COc2ccccc21
InChIKey	ODQWQRRAPPTVAG-UHFFFAOYSA-N
PubChem CID	3158
ChEMBL	CHEMBL1628227
DTXSID	DTXSID7022966
현지명	독세핀

화학 및 물리적 성질

XLogP	4.3
극성 표면적	12.5
수소 결합 공여자 수	0
수소 결합 수용자 수	2
회전 가능 결합 수	3
무거운 원자 수	21
형식 전하	0
복잡도	363
의약품	DEA NFLIS-Drug Category -> Depressants and Tranquilizers
LogP(분배 계수)	log Kow = 0.6743.75
냄새	ODORLESS
맛	BITTER
Color/Form	OILY LIQUID CONSISTING OF A MIXTURE OF CIS- & TRANS- ISOMERS
용해도	WHITE CRYSTALLINE SUBSTANCE1 G SOL IN 1 ML WATER, 2 ML ALCOHOL, 10 ML CHLOROFORM /HYDROCHLORIDE/In water, 31.57 mg/l at 25 °C.3.19e-02 g/L
Human Drugs	Breast FeedingLactationMilk, HumanAntidepressive AgentsAntidepressive Agents, Tricyclic
끓는 점	154-157 ºC at 0.03 mmHg154-157 °C @ 0.03 MM HGbp0.03 154-157°bp0.2 260-270°
Decomposition	When heated to decomposition it emits toxic fumes of nitroxides.
녹는점	185-191 ºCCrystals, melting point 184 to 186 °C, 188 to 189 °C (a cis-trans mixture of approx 1:5) /HYDROCHLORIDE/Crystals, melting point 161 to 164 °C, 168 to 169 °C /MALEATE/Melting point 192 to 193 °C /trans-HYDROCHLORIDE/Crystals, melting point 209 to 210.5 °C /cis-HYDROCHLORIDE/184 - 186 °C187-189°C
Physical Description	Solid
Stability/Shelf Life	DECOMP SLOWLY IN LIGHT, NONHYGROSCOPIC UP TO 75% RELATIVE HUMIDITY, RELATIVELY STABLE IN HEAT /HYDROCHLORIDE/
밀도	1.0594 (rough estimate)
굴절률	1.5000 (estimate)
저장 조건	Sealed in dry,2-8°C
pKa(산도 계수)	9.40±0.28(Predicted)
용해도	31.57mg/L(25℃)
EPA	Doxepin (1668-19-5)

안전 및 규제

규제 정보	Doxepin: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - 1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-: Human health tier I assessment
FDA 요건	Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).
보관 조건	Doxepin hydrochloride capsules and oral concentrate should be protected from direct sunlight and stored in well-closed and tight, light-resistant containers, respectively, at a temperature between 15 and 30 °C. /Doxepin hydrochloride/
처리 방법	SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Treatment	Obtain an ECG and immediately initiate cardiac monitoring. Protect the patient's airway, establish an intravenous line and initiate gastric decontamination. A minimum of six hours of observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is strongly advised. If signs of toxicity occur at any time during this period, extended monitoring is recommended. (L1712)
상호 작용	/DOXEPIN/...MAY...POTENTIATE THE DEPRESSANT EFFECT OF ALCOHOL. /HYDROCHLORIDE/INHIBITION OF THE ANTIHYPERTENSIVE EFFECT OF GUANETHIDINE CAN OCCUR WITH DOSES OF 200-300 MG/DAY. /HYDROCHLORIDE/DOXEPIN MAY POTENTIATE ORAL ANTICOAGULANTS, AMPHETAMINES, OTHER ANTICHOLINERGICS, MEPROBAMATE, PHENOTHIAZINES, THIOXANTHENE TRANQUILIZERS. DOXEPIN MAY ANTAGONIZE PROPRANOLOL /THEORETICALLY/, METHYLDOPA. DOXEPIN MAY BE ANTAGONIZED BY BARBITURATES. DOXEPIN MAY BE POTENTIATED BY THYROID PREPN.DOXEPIN MAY FORM HAZARDOUS COMBINATIONS WITH RESERPINE, ESTROGENS, PSYCHOTROPICS, MAO INHIBITORS, BENZODIAZEPINES.For more Interactions (Complete) data for DOXEPIN (28 total), please visit the HSDB record page.

용도

Used clinically to treat anxiety and depression. Antidepressant