Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
에드로포니오클로루로[DCIT]
에드로포니오클로루로[DCIT] · Edrofonio cloruro [DCIT] · ethyl-(3-hydroxyphenyl)-dimethylazanium · N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium
![에드로포니오클로루로[DCIT] 분자 구조식](/img/chemical/3202.png)
식별자 및 물리적 특성
| CAS No. | 116-38-1 |
|---|---|
| 분자식 | C10H16NO+ |
| 평균 분자량 | 166.24 g/mol |
| 단동위원소 질량 | 166.12318913 g/mol |
| SMILES | CC[N+](C)(C)c1cccc(O)c1 |
| InChIKey | VWLHWLSRQJQWRG-UHFFFAOYSA-O |
| PubChem CID | 3202 |
| ChEMBL | CHEMBL1104 |
| ChEBI | CHEBI:251408 |
| DTXSID | DTXSID4046943 |
| 현지명 | 에드로포니오클로루로[DCIT] |
화학 및 물리적 성질
| XLogP | 1.8 |
|---|---|
| 극성 표면적 | 20.2 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 12 |
| 형식 전하 | 1 |
| 복잡도 | 145 |
| LogP(분배 계수) | -2.95 |
| 용해도 | Appreciable as liquid hydrochloride salt4.86e-02 g/L |
| 녹는점 | 162-163 |
| Physical Description | Liquid |
안전 및 규제
| 유해 작용 | The adverse effects of edrophonium occur due to the increased levels of acetylcholine binding to muscarinic acetylcholine receptors. The more serious adverse effects are cardiac arrhythmias, especially bradycardia, atrioventricular block, and cardiac arrest. The muscarinic cholinergic adverse effects also include bronchoconstriction due to airway smooth muscle contraction secondary to increased stimulation of muscarinic receptors. Other adverse effects include bronchial secretions, diarrhea, salivation, lacrimation, increased urinary frequency and urgency, and miosis. Clinicians can attenuate most of the adverse effects with the simultaneous administration of atropine, which functions as a muscarinic receptor antagonist to prevent developing these cholinergic adverse effects. |
|---|---|
| 독성 요약 | Overdose of edrophonium will result in muscarinic symptoms due to the cholinergic crisis manifested by excessive acetylcholine binding to muscarinic receptors. The cholinergic crisis includes diarrhea, increased urination, miosis, muscle weakness, bronchospasm, bradycardia, emesis, and lacrimation. The more serious outcomes of edrophonium overdose involve respiratory muscle weakness and cardiac arrhythmias that can progress to a fatal outcome. Hence, clinicians must ensure patent airway and circulation. The treatment of an edrophonium overdose is atropine. Atropine is an ideal antidote for edrophonium since it has a similar onset of action as edrophonium. Atropine functions by competitively inhibiting the muscarinic receptors on structures innervated by postganglionic cholinergic nerves and inhibiting muscarinic receptors on smooth muscle. Atropine can be administered up to 1.2 mg intravenously initially and repeated every 20 minutes until secretions are controlled. If convulsions are present, clinicians should institute appropriate supportive measures. For convulsions, supportive treatment is required. |
| Drug Induced Liver Injury | Benchmark Dataset for the Liver Toxicity Knowledge Base (LTKB)edrophoniumEnlon®CholinergicsNot Applicableno-DILI-concern |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during LactationEdrophonium is no longer marketed in the US. No information is available on the use of edrophonium during breastfeeding. However, because of its short half-life and quaternary ammonium structure, it is unlikely to be excreted into breastmilk or orally absorbed by the infant. Administering the drug just after breastfeeding and waiting 2 to 3 hours before breastfeeding again should avoid any adverse reactions in the infant.◉ Effects in Breastfed InfantsRelevant published information was not found as of the revision date.◉ Effects on Lactation and Breastmilk |
용도
용도
Antidote (to curare principles); diagnostic aid (myasthenia gravis).