기본 정보
- CAS
161448-79-9- 표준 SMILES
CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC.Cl- InChIKey
GDWDBGSWGNEMGJ-UHFFFAOYSA-N- 분자식
- C13H21ClN2O3S
- 평균 분자량
- 320.84 g/mol
- 단동위원소 질량
- 320.0961414
개요
Articaine Hydrochloride is the hydrochloride salt form of articaine, an amide-type local anesthetic. Articaine hydrochloride reversibly blocks nerve impulse conduction by binding to specific membrane sodium ion channels thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. This results in a loss of sensation at the injection site. Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine.
이름 및 식별자
- 우선 이름
- Articaine Hydrochloride
- IUPAC
- methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate;hydrochloride
이름 및 동의어
ARTICAINE HYDROCHLORIDE23964-57-0Articaine HClUltracainSeptanestUltracaineUbistesineHoe-045HOE 045HOE 40045DTXSID2045444Hoe-40045
이름 더 보기
QS9014Q792DTXCID00254444-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl2-Thiophenecarboxylic acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochlorideRefChem:916258Hoe045Hoe40045245-957-7
데이터베이스 식별자
- CAS
161448-79-9、23964-57-0- PubChem CID
- 32169
- DTXSID
DTXSID2045444- ChEMBL
CHEMBL1200819- UNII
- QS9014Q792
- EC Number
- 245-957-7
물성
구조 계산 물성
- 극성 표면적
- 95.7 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 20
- 형식 전하
- 0
- 복잡도
- 325
실험 및 물리화학적 성질
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anesthetics, Local
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (80.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 216 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (80.6%)
독성 정보
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
화학 및 산업
약리 정보
FDA Pharmacological Classification
ARTICAINE HYDROCHLORIDE
Local Anesthesia [PE]; Amide Local Anesthetic [EPC]; Amides [CS]
MeSH Pharmacological Classification
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
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