에리트로마이신

6-((4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-((5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione

HCID 3255CAS 114-07-8

기본 정보

표준 SMILES
CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C(=O)C(C)C(O)C1(C)O
InChIKey
ULGZDMOVFRHVEP-UHFFFAOYSA-N
분자식
C37H67NO13
평균 분자량
733.9 g/mol
단동위원소 질량
733.4612412

개요

See also: Erythromycin (annotation moved to); Buserelin (annotation moved to); Erythromycin ethyl succinate (annotation moved to) ... View More ...

이름 및 식별자

우선 이름
6-((4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-((5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
IUPAC
6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
현지명
에리트로마이신
영어명
Erythromycin
분자식
C37H67NO13
분자량
733.93

이름 및 동의어

DTXSID908592066-((4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-((5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione6-{[4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dioneRefChem:1073650DTXCID80196652ErythromidAbboticinErycinumIlocapsErycinKesso-MycinTaimoxin-F
이름 더 보기
에리트로마이신USPERYTHROMYCIN BASEemERYTHROMYCIN Aerytromycin(-)-ErythromycinErythromycin A CRSERYC
ErythrocinPantomicinaERYTHROMYCIN A DIHYDRATEerythroErmycinErycenErytabInderm

데이터베이스 식별자

CAS
114-07-8
PubChem CID
3255
DTXSID
DTXSID90859206
ChEMBL
CHEMBL1671887

물성

구조 계산 물성

XLogP
2.7
극성 표면적
194 Ų
수소 결합 공여자 수
5
수소 결합 수용자 수
14
회전 가능 결합 수
7
무거운 원자 수
51

실험 및 물리화학적 성질

DrugsPharmaceuticals

물리화학적 성질

녹는점
133 °C · 133 °C
끓는 점
719.69 °C · 719.69°C (rough estimate)
밀도
1.1436 · 1.1436 (rough estimate)
굴절률
-74 ° · -74 ° (C=2, EtOH)
저장 조건
Inert atmosphere,Room Temperature
용해도
에탄올: 가용성

화학적 성질

White to off white crystalline powder

안전 및 규제

안전 데이터

wgk
2
rtecs
KF4375000
독성
LD50 oral in rat: 4600mg/kg
HS 번호
29415000
risk_code
42/43-36/37/38
hazard_code
Xn,Xi

화학 및 산업

응용 분야 · 3건

용도에리트로마이신(erythromycin)은 수많은 병균 감염 치료에 사용되는 항생물질이다. 여기에는 기도 감염, 피부 감염, 클라미디아 감염증, 골반염, 매독이 포함된다. 신생아의 그룹 B 연쇄구균감염의 예방을 위해 임신 중에 사용할 수도 있으며, 위마비 개선에도 이용된다. 수액 또는 구강을 통해 투여할 수 있다.

개요Erythromycin ethyl succinate is a mixed double ester pro-drug in which one carboxyl of succinic acid esterifies the C-2′ hydroxyl of erythromycin and the other ethanol. This pro-drug frequently is used in an oral suspension for pediatric use largely to mask the bitter taste of the drug. Film-coated tablets also are used to deal with this. Some cholestatic jaundice is associated with the use of EES.

용도Erythromycin A is a 14-membered macrocyclic lactone with broad spectrum antibiotic activity, isolated from Saccharopolyspora erythraea (formerly Streptomyces erythreus) in 1952. Erythromycin is one of only a handful of microbial metabolites to have profoundly shaped the treatment of bacterial disease in the last 50 years. Erythromycin has given rise to new generations of semi-synthetic derivatives with improved stability and potency. Our product has been HPLC-purified to remove contaminants and degradation products.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]

추가 설명

정의An antibiotic produced by growth of Streptomyces erythreus Waksman. It is effective against infections caused by Gram-positive bacteria, including some β-hemolytic streptococci, pneumococci, and staphylococci.

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