Erythrosine

HCID 3259CAS 15905-32-5
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기본 정보

표준 SMILES
O=C1OC2(c3ccccc31)c1cc(I)c(O)c(I)c1Oc1c2cc(I)c(O)c1I
InChIKey
OALHHIHQOFIMEF-UHFFFAOYSA-N
분자식
C20H8I4O5
평균 분자량
835.9 g/mol
단동위원소 질량
835.65506536

개요

Fd&c red no. 3 is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]").<br /> Fd&c red no. 3 belongs to the family of Xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene ring joined to each other by a pyran ring.

이름 및 식별자

우선 이름
Erythrosine
IUPAC
3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one
영어명
ERYTHROSIN B
분자식
C20H8I4O5
분자량
835.89

이름 및 동의어

ERYTHROSINEE1273',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-oneFD & C red no. 33',6'-dihydroxy-2',4',5',7'-tetraiodospiro(2-benzofuran-3,9'-xanthene)-1-oneFDC Red No. 3RefChem:591122Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt16423-68-0Erythrosine, sodium anhydrousNSC-36685Erythrosin B
이름 더 보기
ERYTHROSINtraiodo-Nsc328781cherry redBErythrosiIODOEOSINECI 45430:2tetraiodo-
Tetraiodofluorescein15905-32-5Solvent Red 140IodeosinErythrosine acidErythrosine, phenolic2',4',5',7'-Tetraiodofluorescein2,4,5,7-Erythrosin

데이터베이스 식별자

CAS
15905-32-5、16423-68-0
PubChem CID
3259
DTXSID
DTXSID7044843
ChEMBL
CHEMBL1332616
UNII
1A878FZQ9B
EC Number
240-046-0
Nikkaji
J25.137B

물성

구조 계산 물성

XLogP
6
극성 표면적
76 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
5
회전 가능 결합 수
0
무거운 원자 수
29

실험 및 물리화학적 성질

CosmeticsHair dyeing; Cosmetic colorant
Solubility0.7 mg/mL
Melting Point303 °C
Physical Description · 3건

Liquid; Other Solid

Red powder or granules.

Solid

Collision Cross Section217.9 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID7021233]

물리화학적 성질

녹는점
303 °C · 303 °C (dec.)(lit.)
끓는 점
628.3 · 628.3±55.0 °C(Predicted)
밀도
2.4391 · 2.4391 (estimate)
저장 조건
room temp
용해도
휘발성 액체: 용해성
물리적 상태
가루

화학적 성질

orange-red fine powder

안전 및 규제

GHS 분류

GHS Classification · 3건

This chemical does not meet GHS hazard criteria for 94.9% (37 of 39) of all reports.

Not Classified

Aggregated GHS information provided per 39 reports by companies from 3 notifications to the ECHA C&L Inventory.

유해성 정보

Regulatory Information · 4건

Chemical: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt

Regulation (EC) No 1333/2008 (amended)

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Erythrosine: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesNot Classified

독성 정보

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

안전 데이터

wgk
2
tsca
TSCA listed
rtecs
LM5940000
독성
A food color formerly approved for use in the United States and Europe. It was used primarily in jams and marmalades, maraschino cherries, pickles and relishes, etc. The LD50 in rats is 150 mg/kg, i.p., and 600 mg/kg, p.o. Erythrosine has a variety of actions in vitro due in large measure to its ability to affect biological membranes and lipophilic sites of enzymes. Such data have led to the hypothesis that erythrosine could be neurotoxic, but both clinical and preclinical data have suggested that erythrosine is not likely to be neurotoxic at doses that might be encountered. Two other toxicological issues have been raised with this food color. It has been suggested to be a potential, if weak, carcinogen, and it may also contribute to potential thyroid toxicity resulting from release of iodine.
HS 번호
29329990
safety_code
22-24/25

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 1건

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.

Cellular LocationsMembrane

용도 및 제조

U.S. Production2023: 108,000 lb
Consumer UsesPigment
Use Classification · 5건

Food additives

Food Additives -> COLOUR -> JECFA Functional Classes

Food Additives -> COLOUR -> JECFA Functional Classes

Food Additives -> COLOUR -> JECFA Functional Classes

Cosmetics -> Hair dyeing; Cosmetic colorant

General Manufacturing Information · 2건

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-: ACTIVE

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-2',4',5',7'-tetraiodo-, sodium salt (1:2): ACTIVE

응용 분야 · 1건

용도Erythrosin B is used as a red coloring in some foods such as cherries and fish. It is used as printing ink, dental plaque disclosing agent and biological stain. It finds application as a radiopaque medium and sensitizer for orthochromatic photographic films. It is utilized as a cake-decorating gel. In addition to this, it is used in sweets such as candies and popsicles.

제조 방법

Fluorescein (C.I.Acid Yellow 73, C.L 45350) in aqueous solution or Tetraiodide in ethanol, and made the free acid form.

상·하류 제품 정보

상류 원료

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

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