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기본 정보
- CAS
298690-60-5- 표준 SMILES
Cc1ccc(S(=O)(=O)N2CCC[C@H]2c2ccc(F)cc2)cc1- InChIKey
DAEHFYNGSSBGSS-KRWDZBQOSA-N- 분자식
- C17H18FNO2S
- 평균 분자량
- 319.401 g/mol
- 단동위원소 질량
- 319.10422804
이름 및 식별자
- 우선 이름
- (2S)-2-(4-Fluorophenyl)-1-(4-methylbenzene-1-sulfonyl)pyrrolidine
- IUPAC
- (2S)-2-(4-Fluorophenyl)-1-(4-methylbenzene-1-sulfonyl)pyrrolidine
- 영어명
- Ro 67-7476
- 분자식
- C17H18FNO2S
- 분자량
- 319.39
이름 및 동의어
Ro 67-7476RO67-7476RO-67-7476Ro 67-7476, 10 mM in DMSO(S)-2-(4-Fluorophenyl)-1-tosylpyrrolidine(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidinePyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
데이터베이스 식별자
- CAS
298690-60-5- PubChem CID
- 32681978
- DTXSID
DTXSID80652763- ChEMBL
CHEMBL4303496- Nikkaji
- J1.666.759E
물성
물리화학적 성질
- 끓는 점
- 452.9 · 452.9±55.0 °C(Predicted)
- 밀도
- 1.268 · 1.268±0.06 g/cm3(Predicted)
- 저장 조건
- Store at RT
- 용해도
- 30 · DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
- 산도 계수 (pKa)
- -5.53 · -5.53±0.40(Predicted)
- 물리적 상태
- 가루
- 색상
- White to yellow
화학 및 산업
응용 분야
개요Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).
용도Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.
공급사36 곳
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Aladdin Scientific[email protected]
星基医药（上海）有限公司15705593425 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
南京诺利斯医药科技有限公司13901585132 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
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