데이터를 보충하는 중입니다. 보통 1분 이내에 완료됩니다
기본 정보
- 표준 SMILES
CCC1(C)CC(=O)NC1=O- InChIKey
HAPOVYFOVVWLRS-UHFFFAOYSA-N- 분자식
- C7H11NO2
- 평균 분자량
- 141.17 g/mol
- 단동위원소 질량
- 141.07897859
이름 및 식별자
- 우선 이름
- Ethosuximide
- IUPAC
- 3-Ethyl-3-methylpyrrolidine-2,5-dione
- 영어명
- ETHOSUXIMIDE
- 분자식
- C7H11NO2
- 분자량
- 141.17
이름 및 동의어
Zarontinh940H 940H-490Pemalpm671Suxinci366EtomalPM 671
데이터베이스 식별자
- CAS
77-67-8- PubChem CID
- 3291
- DTXSID
DTXSID7023019- ChEMBL
CHEMBL696- ChEBI
CHEBI:4887- UNII
- 5SEH9X1D1D
- EC Number
- 201-048-7
- Nikkaji
- J1.477J
물성
물리화학적 성질
- 녹는점
- 51 °C · 51 °C
- 끓는 점
- 150 °C · 150 °C / 12mmHg
- 밀도
- 1.1522 · 1.1522 (rough estimate)
- 굴절률
- 1.5026 · 1.5026 (estimate)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 100 mg/mL · 에탄올: 100mg/mL
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 9.5 · pKa 9.5 (Uncertain)
- 색상
- 흰색에서 황백색까지
- 수용성
- 190 g/L · 190g/L(25℃)
- Merck
- 14 · 14,3748
- BCS Class
- 1 · 1,3
- 주요 응용
- 법의학 및 독성학의약품(소분자)수의사
- InChI
- InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
- InChIKey
- HAPOVYFOVVWLRS-UHFFFAOYSA-N
- SMILES
- N1C(=O)CC(CC)(C)C1=O
화학적 성질
White to Off-White Solid
안전 및 규제
안전 데이터
- wgk
- 3
- rtecs
- WN2800000
- 독성
- LD50 in mice (g/kg): 1.65 i.p.; 1.75 orally (Najer)
- HS 번호
- 2925190100
- risk_code
- 22-39/23/24/25-23/24/25-11
- hazard_code
- Xn,T,F
- safety_code
- 36-45-36/37-16-7
- Hazard Classifications
- Acute Tox. 4 Oral
- 스토리지 클래스
- 13 - Non Combustible Solids
- 유해 물질 데이터
- 77-67-8(Hazardous Substances Data)
화학 및 산업
응용 분야
용도Ethosuximide is an anticonvulsant drug that is used in minor forms of epilepsy.
일반 설명Ethosuximide is considered the prototypical anticonvulsantneeded for treating patients with absence seizures.Ethosuximide and the N-dealkylated active metabolite ofmethsuximide work by blocking the lowthresholdT-type calcium channels, thereby reducing thehyperexcitability of thalamic neurons that is specifically associatedwith absence seizure.
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추가 설명
정의ChEBI: A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffect ve against tonic-clonic seizures.
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