Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylenediamine
1,2-디아미노에탄 · 에틸렌다이아민 · 에틸렌디아민 · EDA · ETHANE-1,2-DIAMINE · 1,2-DIAMINOETHANE · 1,2-ETHANEDIAMINE · 1,2-Ethylenediamine
식별자 및 물리적 특성
| CAS No. | 107-15-3 |
|---|---|
| 분자식 | C2H8N2 |
| 평균 분자량 | 60.1 g/mol |
| 단동위원소 질량 | 60.06874826 g/mol |
| SMILES | NCCN |
| InChIKey | PIICEJLVQHRZGT-UHFFFAOYSA-N |
| PubChem CID | 3301 |
| ChEMBL | CHEMBL816 |
| ChEBI | CHEBI:30347 |
| EC No. | 203-468-6 |
| DTXSID | DTXSID5021881 |
| 현지명 | 에틸렌디아민 |
화학 및 물리적 성질
| XLogP | -2 |
|---|---|
| 극성 표면적 | 52 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 4 |
| 형식 전하 | 0 |
| 복잡도 | 6 |
| 물질 분류 | Nitrogen Compounds -> Amines, AliphaticCorrosives |
| 의약품 | Pharmaceuticals -> Listed in ZINC15 |
| pH | 11.9 @ 25 °C (25% soln)12.2 (100g/l, H2O, 20℃) |
| SpringerMaterials Properties | 15N nuclear magnetic resonance spectrum |
| 농약 | Pesticide -> EPA IRIS |
| LogP(분배 계수) | log Kow = -2.04 @ pH 13-1.2 |
| 냄새 | Ammonia-like강한 암모니아 냄새암모니아 같은 온화한 암모니아 냄새. |
| 식품 첨가물 | TRACER -> FDA Substance added to food |
| 밀도 | 0.898 at 77 °F (EPA, 1998) - Less dense than waterwill float0.898 @ 25 °C/4 °CSaturated liquid density: 56.650 lb/cu ftliquid heat capacity: 0.694 Btu/lb-Fsaturated vapor pressure: 0.216 lb/sq insaturated vapor density: 0.00228 lb/cu ft (all at 70 °F)Relative density (water = 1): 0.90.911.46 @ 20°C0.899 g/mL at 25 °C (lit.) |
| Viscosity | 0.0154 cP @ 25 °C0.0154 cP at 25 °C |
| Color/Form | Water-white liquidColorless, viscous liquid ... [Note: A solid below 47 degrees F]. |
| 용해도 | greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)Crystalssublimes without meltingfreely sol in waterpractically insol in alc /Dihydrochloride/Sol in benzene unless insufficiently driedslightly sol in etherSOL IN ALL PROPORTIONS IN ETHYL ALCOHOLVERY SOL IN WATERWater solubility = 1X10+6 mg/lMiscible with water, oxygenated and aromatic solvents에탄올: 용해성(lit.) |
| 녹는점 | 8.5 °C (lit.) |
| 끓는 점 | 118 °C (lit.) |
| 증기 밀도 | 2.07 (vs air) |
| 증기압 | 10 mm Hg ( 20 °C) |
| 굴절률 | n20/D 1.4565(lit.) |
| 인화점 | 93 °F |
| 저장 조건 | Flammables area |
| pKa(산도 계수) | 10.712(at 0℃) |
| 물리적 상태 | 액체, 공기 중 발연 |
| 비중 | 0.899 |
| 색상 | 무색~담황색 |
| 폭발한계 | 2-17%(V) |
| 용해도 | 혼용 가능 |
| 비열 | Cp(liquid): 2.87 J/(g·K), at 25℃ |
| Merck | 14,3795 |
| BRN | 605263 |
| 헨리 상수 | 1.69(x 10-9 atmm3/mol) at 25 °C (Westheimer and Ingraham, 1956) |
| 유전율 | 16.0(18℃) |
| 주요 응용 | 청소용품화장품환경음식 및 음료개인 위생 관리 |
| InChI | 1S/C2H8N2/c3-1-2-4/h1-4H2 |
| InChIKey | PIICEJLVQHRZGT-UHFFFAOYSA-N |
| SMILES | NCCN |
| LogP(분배 계수) | -1.6 at 20℃ |
| NIST | Ethylenediamine(107-15-3) |
| EPA | Ethylenediamine (107-15-3) |
화학적 성질
Ethylenediamine, a polyamine, is a strongly alkaline, colorless, clear, thick liquid. Ammonia odor. A solid below 8.5℃. The Odor Threshold is 1.0 ppm
안전 및 규제
| GHS 분류 | DangerH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2078) of reports.H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids] |
|---|---|
| 규제 정보 | Chemical: 1,2-EthanediamineHazard Traits - Respiratory ToxicityCommission Regulation No 844/20121,2-Ethanediamine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Ethanediamine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 02-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15765Substance: Ethylenediamine |
| 기타 안전 정보 | IMAP assessments - 1,2-Ethanediamine: Environment tier I assessment |
| 운송 라벨(DOT) | Corrosive Flammable Liquid |
| 화재 위험 | Burning rate: 2.2 mm/minute. When exposed to heat or flame, the material has a moderate fire potential. The material can react readily with oxidizing materials. Containers may explode in heat of fire. Material emits nitrogen oxides when burned. Avoid carbon disulfide, silver perchlorate, imines, oxidizing materials. Stable. Hazardous polymerization may not occur. (EPA, 1998)· Flammable/combustible material.Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 34 °C explosive vapour/air mixtures may be formed. |
| 화재 가능성 | FLAMMABLE LIQUID WHEN EXPOSED TO HEAT, FLAME OR OXIDIZERS.Contact with ... chlorinated organic cmpd may cause fires ... . |
| 건강 유해성 | Vapor inhalations at a concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation and produce a tingling sensation. Inhalation at concentrations of 400 ppm or greater leads to severe nasal irritation. Respiratory irritation may result. Many individuals are hypersensitive to ethylenediamine exposuretherefore, safe threshold limits are difficult to set. (EPA, 1998)· May cause toxic effects if inhaled or ingested. |
| 유해성 요약 | Liquid causes second degree burns after contact for a few minutes[CHRIS] Corrosive to skin[Quick CPC] Ethylenediamine is used in topical creams and suppositories, e.g., nystatin cream and aminophylline suppositories. Allergic contact dermatitis has been reported in a pharmacist and in healthcare workers. [Marks, p. 85-7] Allergic contact dermatitis in healthcare workers reported after exposure to intravenous aminophylline preparations containing ethylenediamine[Kanerva, p. 1520] Occupational asthma reported in shellac handler and photographer[Malo] Can cause pulmonary edema after an acute inhalation exposure[ICSC] Danger of skin and airway sensitization[MAK] Humans complain of nasal irritation after inhaling concentrations of 200 ppm for 5-10 minutes. [CAMEO] A lachrymator[CHEMINFO] |
| 운송 번호 및 가이드(DOT) | 1604 132 |
| FDA 요건 | Ethylenediamine is an indirect food additive for use only as a component of adhesives. |
| 반응성 그룹 | Amines, Phosphines, and Pyridines |
| EC 분류 | Symbol: CR: 10-21/22-34-42/43S: (1/2)-23-26-36/37/39-45 |
| UN 분류 | UN Hazard Class: 8UN Subsidiary Risks: 3UN Pack Group: II |
| 소화 | Wear full protective clothing including gloves and boots. If necessary to enter closed area, wear full-faced gas masks with self-contained breathing apparatus. Use water spray, dry chemical, alcohol foam, or carbon dioxide. Do not use water in case of drum or tank fires. If a leak or spill has not ignited, use water spray to reduce the vapors and dilute spills to nonflammable mixtures. Use water to keep fire-exposed containers cool. (EPA, 1998)Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 응급 조치 | Fresh air, rest. Refer immediately for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. |
| 누출 비상 조치 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| 응급 처치 | Signs and Symptoms of Acute Ethylenediamine Exposure: Acute exposure to ethylenediamine may result in cough, difficulty in breathing, irritation of the lungs, and pneumonia. Nausea, vomiting, and diarrhea are often seen. Contact with ethylenediamine may result in redness, pain, irritation, and burns.General First Aid:(General first aid procedures) |
| 안전 보관 | Fireproof. Separated from strong oxidants, acids, chlorinated organic compounds and food and feedstuffs. Cool. Well closed. Store only in original container. |
| 노출 관리 및 개인 보호 | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| 소화 절차 | Use water spray, dry chem, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams may be ineffective and spread material.Do not use water in case of drum or tank fires. |
| 보관 조건 | Outside or detached storage is preferred. Avoid oxidizing materials, acids, and sources of halogens. Store in a cool, dry, well-ventilated location. |
| 정리 방법 | 1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. If in the liq form, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. ... 4. If in the solid form, collect, allow to melt, and dispose of the liq as above.Overspread /spill with/ sufficient sodium bisulfate and sprinkle water. |
| 비화재 누출 대응 | Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: |
| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Ethylenediamine may be disposed of by atomizing in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.Catalytic /destruction/ of waste gases from ethylenediamine production is described.Removal of ethylenediamine from wastewater using ion exchange is described. |
| 누출 처리 | Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Collect the spilled substance into containers. The container should be made of the same material as the original container. |
| 상호 작용 | Ethylenediamine (EDA) (31.6-1000 mg/kg, ip) inhibited the convulsive effects of pentylenetetrazol (100 mg/kg, ip) in mice. EDA (100-1000 mg/kg, ip) incr the convulsion threshold to the iv infusion of 3 convulsants in the order pentylenetetrazol > bicuculline > strychnine.A 37-yr-old pt sensitized to ethylenediamine by topical use of a steroid cream for scaly rash, developed an itchy morbilliform rash affecting the whole body following piperazine citrate therapy for threadworms. |
| 표적 장기 | Skin, respiratory system, liver, kidneys |
| 생태독성 수치 | LC50 Pimephales promelas (fathead minnow) 115.7 mg/l/96 hr @ 22 °C (95% confidence limit 98.6-131.6 mg/l) /Static bioassay/TLM: ORYZIAS LATIPES 1000 MG/L/24 HR /CONDITIONS OF BIOASSAY NOT SPECIFIED/Toxicity Threshold (Cell Multiplication Inhibition Test) Uronema parduczi Chatton-Lwoff (protozoa) 52 mg/l /Conditions of bioassay not specified/Toxicity Threshold (Cell Multiplication Inhibition Test) Scenedesmus quadricauda (green algae) 0.85 mg/l /Conditions of bioassay not specified/For more Ecotoxicity Values (Complete) data for ETHYLENEDIAMINE (9 total), please visit the HSDB record page. |
| 환경 거동 | TERRESTRIAL FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to have slight mobility in soil(SRC). Volatilization of ethylenediamine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.73X10-9 atm-cu m/mole(3). The potential for volatilization of ethylenediamine from dry soil surfaces may exist based upon a vapor pressure of 12.1 mm Hg(4). However, adsorption to soil may attenuate volatilization(SRC). Based on screening studies(5-7), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in soil are available. Ethylenediamine may also form stable complexes with metal ions(8) in soil, but again, experimental data are lacking(SRC).AQUATIC FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.73X10-9 atm-cu m/mole(4). As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonatedthe dissociated form will not volatilize. According to a classification scheme(5), an estimated BCF of less than 1(SRC), from its log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Based on screening studies(8-10), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in water are available. Complexation of ethylenediamine with transition metals(11) in the water or reaction with humic materials(12) is possible(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylenediamine, which has a vapor pressure of 12.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor. Vapor-phase ethylenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.3x10-11 cu cm/molecule-sec at 25 °C(3) using a structure estimation method(3). As ethylenediamine is miscible in water(4), washout by rain will also be an important removal process(SRC). |
| 식품 조사 수치 | ... Amines from decomposing fish ... /Amines/ |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 노출 경로 | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Signs and Symptoms | Cough. Sore throat. Shortness of breath. Burning sensation. Wheezing. Shortness of breath.Redness. Pain. Burning sensation. Skin burns.Redness. Pain. Blurred vision. Severe burns.Burns in mouth and throat. Sore throat. Burning sensation. Abdominal pain. Shock or collapse.irritation nose, respiratory systemsensitization dermatitisasthmaliver, kidney damage |
| EPA IRIS Information | Ethylene diamine |
| Medical Surveillance | ... A complete history and physical exam /is required/ ... to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Persons with a history of asthma, allergies, or unknown sensitization to ethylenediamine would be expected to be at incr risk from exposure. Exam of the resp system, liver, and kidneys should be stressed. The skin should be examined for evidence of chronic disorders. ... Should be repeated on an annual basis. |
| Soil Adsorption/Mobility | Ethylenediamine has two primary amine groups and at the pH range found in most soils it is expected to be partially protonated given a pKa1 of 10.7 and a pKa2 of 7.6(1). An average Koc of 4766 (range=2071 to 6160) was measured for ethylenediamine in six different soilsfive were from the vadose zone and one from an aquifer (saturated zone)(2). pH values ranged from 6.0 to 9.6 and the fraction of organic carbon from 0.0024 to 0.0391 for this group of soils. Soils with increased cation exchange capacity and organic content had greater affinity for ethylenediamine(2). |
| TSCA Test Submissions | Ethylenediamine (CAS # 107-15-3) was evaluated for acute oral toxicity in groups of Fischer 344 rats (5/sex/group) administered single oral doses of 200, 400, 800, 1200, and 1800 mg/kg bodyweight as a monohydrochloride or dichlorohydride salt in water. Mortality was attributed to treatment at doses of 1800 mg/kg (9/10) and 1200 mg/kg (2/10)An LD50 was not calculated. Clinical signs observed in the 1200 mg/kg group included emaciation, bluish extremities and diarrhea. Upon necropsy, no gross pathology was observed. |
| 대기 기준 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethylenediamine is produced, as an intermediate or a final product, by process units covered under this subpart. |
| CERCLA 보고 수량 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Ethylenediamine is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10,000 lbs.Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| 청정수법 요건 | Ethylenediamine is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| DHS Chemicals of Interest (COI) | Ethylenediamine120000Toxic chemical that can be released at a facility. |
| 주 식수 지침 | (FL) FLORIDA 10,000 ug/l |
| 직업 노출 등급(OEB) | A |
| 직업 노출 한계(OEL) | TWA: 10 ppm (25 mg/m3) |
| 수질 위해 등급(WGK) | 2 |
| 즉시 생명 위험 농도 | 1,000 ppm |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | KH8575000 |
| 운송 번호(UN) | UN 1604 |
| 독성 | LD50 orally in rats: 1.16 g/kg (Smyth) |
| 관세 코드 | 29212110 |
| 위험 문구(R) | 10-21/22-34-42/43 |
| 위험 표시 | C |
| 안전 문구(S) | 23-26-36/37/39-45 |
| 포장분류 | II |
| 위험 등급 | 8Acute Tox. 3 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralAquatic Chronic 3Eye Dam. 1Flam. Liq. 3Resp. Sens. 1BSkin Corr. 1BSkin Sens. 1B |
| 기존화학 물질 | KE-13141 |
| F 고인화성물질 | 10-34 |
| 자연 발화 온도 | 716 °F |
| 저장 분류 | 3 - Flammable liquids |
| 유해 물질 데이터 | 107-15-3(Hazardous Substances Data) |
| 중점관리물질 필터링 | 별표1-57 |
| 사고대비 물질 필터링 | 25 |
용도
개요
에틸렌다이아민(Ethylenediamine)은 유기화합물의 일종이다. 킬레이트제로 작용할 수 있으며 리간드일 경우 en으로 축약시켜 표기하기도 한다. 강염기성이며, 암모니아 냄새가 난다.
용도
에틸렌다이아민은 두 자리 리간드로 작용할 수 있어서, 금속 이온과 배위하여 착물을 형성한다. 따라서 특정한 금속 이온을 농축, 분리, 제거, 이동하는 데 사용될 수 있다.
개요
Ethylenediamine is used in numerous industrial proces ses as a solvent for casein or albumin, as a stabilizer in rubber latex and as a textile lubricant. It can be found in epoxy-resin hardeners, cooling oils, fungicides, and waxes. Contact dermatitis from ethylenediamine is almost exclusively due to topical medicaments. Occupational contact dermatitis in epoxy-resin systems is rather infrequent. Ethylenediamine can cross react with triethylenetetramine and diethylenetriamine. Ethylenediamine was responsible for sensitization in pharmacists handling aminophylline suppositories, in nurses preparing and administering injectable theophylline, and in a laboratory technician in the manufacture of aminophylline tab lets.
용도
[Note—Edamine is the recommended contraction for the ethylenediamine radical.].
일반 설명
Ethylenediamine is a linear aliphatic diamine, widely used as a building block in organic synthesis. It readily forms heterocyclic imidazolidine derivatives, because of its bifunctional nature, having two amines. Ethylenediamine is also utilized as a raw material for the synthesis of chelating agents, polymers, agrochemicals and pharmaceutical intermediates.
제조 및 합성 방법
생산 방법
The production of ethylene-1,2-diamine (EDA) is by the catalytic amination of monoethanolamine or the reaction of aqueous ammonia with 1,2-dichloroethane (Spitz 1979). U.S. Production is estimated at greater than 33,000 tons in 1975.