Fenoprofen

Fenoprofen D3 · Einecs 249-770-1 · 2-(3-Phenoxyphenyl) · 3-Phenoxyhydratropic acid · Fenoprofen, racemic mixture · 2-(m-Phenoxyphenyl)propionic acid · α-Methyl-3-phenoxybenzeneacetic acid · Benzeneacetic acid, a-methyl-3-phenoxy-

https://huagongshe.com/ko/chemical/3342

식별자 및 물리적 특성

CAS No.	29679-58-1
분자식	C15H14O3
평균 분자량	242.27 g/mol
단동위원소 질량	242.09429431 g/mol
SMILES	CC(C(=O)O)c1cccc(Oc2ccccc2)c1
InChIKey	RDJGLLICXDHJDY-UHFFFAOYSA-N
PubChem CID	3342
ChEMBL	CHEMBL1297
ChEBI	CHEBI:5004
EC No.	249-770-1
DTXSID	DTXSID9023045

화학 및 물리적 성질

XLogP	3.3
극성 표면적	46.5
수소 결합 공여자 수	1
수소 결합 수용자 수	3
회전 가능 결합 수	4
무거운 원자 수	18
형식 전하	0
복잡도	271
LogP(분배 계수)	3.13.45
Color/Form	VISCOUS OIL
용해도	Slight (calcium salt)8.11e-02 g/LDMSO : 100 mg/mL (412.76 mMNeed ultrasonic)
Human Drugs	Breast FeedingLactationMilk, HumanAnalgesic AgentsAnti-inflammatory Agents, NonsteroidalPharmaceuticals
끓는 점	168-171 °C @ 0.11 MM HG168-171 °C(Press: 0.11 Torr)
녹는점	168-171
굴절률	INDEX OF REFRACTION: 1.5742 @ 25 °C/D
Physical Description	Solid
Dissociation Constants	4.5PKA= 7.3
Collision Cross Section	157.19 Å² [M+Na]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
밀도	1.183±0.06 g/cm3(Predicted)
저장 조건	Store at -20°C
pKa(산도 계수)	4.20±0.10(Predicted)
물리적 상태	Oil to Thick Oil
색상	무색
EPA	Benzeneacetic acid, ?-methyl-3-phenoxy- (29679-58-1)

안전 및 규제

상호 작용	WHEN FENOPROFEN WAS ADDED TO REGIMEN OF...PT WITH RHEUMATOID ARTHRITIS WHO WERE RECEIVING CORTICOSTEROID OR GOLD THERAPY, THERE WAS SOME EVIDENCE THAT DOSE OF STEROID COULD BE REDUCED & COMBINATION WITH GOLD WAS MORE EFFECTIVE.FOOD DELAYS ABSORPTION...& REDUCES PEAK PLASMA CONCN (ABOUT 30%) & TOTAL ABSORPTION (ABOUT 20%), AS DOES COADMIN OF...ANTACIDS./PLASMA PROTEIN/ BINDING OF FENOPROFEN IS INHIBITED BY CONCOMITANT ADMIN OF INDOMETHACIN & PHENYLBUTAZONE... PLASMA T/2 OF FENOPROFEN IS DECR BY ASPIRIN...FENPROFEN & PROPOXYPHENE ARE ADDITIVE WHEN GIVEN TOGETHER.
Hepatotoxicity	Prospective studies show that up to 15% of patients taking fenoprofen experience at least transient serum aminotransferase elevations. These elevations are generally transient, mild and asymptomatic, and may resolve even with drug continuation. Marked aminotransferase elevations (above 3 times the upper limit of normal (ULN) occur in less than 1% of patients.
Human Toxicity Excerpts	MOST COMMON ADVERSE REACTIONS /ORAL ADMIN/...GI EFFECTS (EG, DYSPEPSIA, CONSTIPATION, NAUSEA, VOMITING)...FEW CASES OF ULCERATION... CNS REACTIONS INCL DROWSINESS, DIZZINESS, HEADACHE, NERVOUSNESS, & CONFUSION. PRURITUS, RASH, SWEATING, PALPITATIONS, TREMOR, TINNITUS, BLURRED VISION, & DECR HEARING...SENSITIVITY TO DRUG...ELEVATIONS OF SERUM TRANSAMINASE, LACTIC DEHYDROGENASE, & ALKALINE PHOSPHATASE LEVELS...IN SOME PT. DECR IN HEMOGLOBIN & HEMATOCRIT...OCCASIONALLY. FENOPROFEN REDUCES PLATELET AGGREGATION & ADHESIVENESS & INCR BLEEDING TIME /ORAL ADMIN/..../FENOPROFEN, ORALLY/ EFFECTIVENESS IN RHEUMATOID ARTHRITIS APPEARS... COMPARABLE TO...ASPIRIN &...INCIDENCE OF GI REACTIONS & AMT OF GI BLEEDING IS LESS THAN WITH ASPIRIN....DRUGS /INCL FENOPROFEN/ HAVE BEEN ASSOC WITH FATAL GI HEMORRHAGE IN RARE CASES.For more Human Toxicity Excerpts (Complete) data for FENOPROFEN (10 total), please visit the HSDB record page.
Drug Induced Liver Injury	Benchmark Dataset for the Liver Toxicity Knowledge Base (LTKB)fenoprofenNalfon®NSAIDs8most-DILI-concern
Effects During Pregnancy and Lactation	◉ Summary of Use during Lactation
관세 코드	2918999090

용도

Fenoprofen is a positive allosteric modulators at melanocortin receptor 3 for treatment of inflammatory diseases in human and mouse model.