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Fluphenazine Decanoate

HCID 3388
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
5002-47-1
표준 SMILES
CCCCCCCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChIKey
VIQCGTZFEYDQMR-UHFFFAOYSA-N
분자식
C32H44F3N3O2S
평균 분자량
591.8 g/mol
단동위원소 질량
591.31063331

개요

Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and a prodrug. It is an organofluorine compound, a member of phenothiazines, a N-alkylpiperazine and a decanoate ester. It is functionally related to a fluphenazine.

이름 및 식별자

우선 이름
Fluphenazine Decanoate
IUPAC
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
영어명
Fluphenazine decanoate
분자식
C32H44F3N3O2S
분자량
591.77

이름 및 동의어

Fluphenazine decanoate5002-47-1ModecateLyogenModiten depotDapotum DFluphenazine depotProlixin decanoateFlufenazine decanoateFluorophenazine decanoateFluphenaline decanoateDEPOT
이름 더 보기
ecanoatedapotumdsq10,733moditendepotzinyl)ethylesterprolixindecanoatefluphenazinedepotflufenazinedecanoate
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoateNSC-169510FMU62K1L3CFluphenazini decanoasDTXSID7023069QD-10733SQ-10733NSC169510

데이터베이스 식별자

CAS
5002-47-1
PubChem CID
3388
DTXSID
DTXSID7023069
ChEMBL
CHEMBL1200854
ChEBI
CHEBI:5124
UNII
FMU62K1L3C
EC Number
225-672-4
Nikkaji
J13.702B

물성

구조 계산 물성

XLogP
9
극성 표면적
61.3 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
9
회전 가능 결합 수
16
무거운 원자 수
41
형식 전하
0
복잡도
765

실험 및 물리화학적 성질

Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점
30 · 30-32°
끓는 점
658.1 · 658.1±55.0 °C(Predicted)
밀도
1.149 · 1.149±0.06 g/cm3(Predicted)
저장 조건
-20 °C · Store at -20°C
용해도
물에는 거의 녹지 않으며, 에탄올과 염화메틸렌에는 잘 녹고, 메탄올에는 잘 녹습니다.
물리적 상태
Oil
산도 계수 (pKa)
7.32 · 7.32±0.10(Predicted)
색상
Light yellow to yellow
주요 응용
의약품(소분자)
InChIKey
VIQCGTZFEYDQMR-UHFFFAOYSA-N
SMILES
FC(F)(F)c1cc2c(cc1)Sc3c(cccc3)N2CCCN4CCN(CC4)CCOC(=O)CCCCCCCCC

화학적 성질

Yellow Oil

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Danger

H300 (40%): Fatal if swallowed [Danger Acute toxicity, oral]

P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P316, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 30 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 2 (40%)

안전 데이터

wgk
WGK 3
rtecs
HE0525000
ridadr
3249
포장분류
II
위험 등급
6.1(a)
Hazard Classifications
Acute Tox. 2 OralRepr. 2
스토리지 클래스
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

FLUPHENAZINE DECANOATE

Phenothiazines [CS]; Phenothiazine [EPC]

MeSH Pharmacological Classification · 2건

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

응용 분야

용도Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.

공급사63 곳

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