9-플루오레닐메틸 클로로폼산

9-Fluorenylmethyl chloroformate

HCID 34367CAS 28920-43-6

기본 정보

표준 SMILES
O=C(Cl)OCC1c2ccccc2-c2ccccc21
InChIKey
IRXSLJNXXZKURP-UHFFFAOYSA-N
분자식
C15H11ClO2
평균 분자량
258.7 g/mol
단동위원소 질량
258.04475727

개요

used for tagging silica-based derivatization reagents in HPLC

이름 및 식별자

우선 이름
9-Fluorenylmethyl chloroformate
IUPAC
9H-fluoren-9-ylmethyl carbonochloridate
현지명
9-플루오레닐메틸 클로로폼산
영어명
9-Fluorenylmethyl chloroformate
분자식
C15H11ClO2
분자량
258.7

이름 및 동의어

28920-43-69-Fluorenylmethyl chloroformate9-Fluorenylmethoxycarbonyl chloride1-(9-Fluorenyl)methyl chloroformateFluoren-9-ylmethyl chloroformate9PLB0BTT90FORMIC ACID, CHLORO-, FLUOREN-9-YLMETHYL ESTERDTXSID10183116RefChem:746059-FLMCDTXCID20105607249-313-6
이름 더 보기
9-플루오레닐메틸클로로폼산9-플루오레닐메틸 클로로폼산FoMc-ClFMOC-Cfmoc-ci9-FluorenylmethylFMOC-C1Fluorenylmethyloxycarbonyl chloride
Fmoc-ClFmoc-chloride(9h-fluoren-9-yl)methyl carbonochloridateFmoc chlorideCarbonochloridic acid, 9H-fluoren-9-ylmethyl ester9H-Fluoren-9-ylmethyl chloroformate9H-fluoren-9-ylmethyl carbonochloridate(9H-Fluoren-9-ylmethoxy)carbonyl Chloride

데이터베이스 식별자

CAS
28920-43-6
PubChem CID
34367
DTXSID
DTXSID10183116
UNII
9PLB0BTT90
EC Number
249-313-6
Nikkaji
J311E

물성

구조 계산 물성

XLogP
4.3
극성 표면적
26.3 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
2
회전 가능 결합 수
3
무거운 원자 수
18

물리화학적 성질

녹는점
62 · 62-64 °C(lit.)
끓는 점
365.79 °C · 365.79°C (rough estimate)
밀도
1.178 · 1.1780 (rough estimate)
굴절률
1.533 · 1.5330 (estimate)
저장 조건
2 · 2-8°C
용해도
0.1 g/mL, · 디옥산: 0.1 g/mL, 투명, 무색

화학적 성질

9-Fluorenyl chloroformate appears as white crystals with a melting point of 62–64 °C. It is soluble in organic solvents such as CH₂Cl₂, THF, and dioxane. It reacts with alcohols, ammonia or amines, and water.

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H302 (17.5%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 3건

Chemical: Carbonochloridic acid, 9H-fluoren-9-ylmethyl ester

Status: Active Update: 29-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/28092

(9-Fluorenylmethyl) chloroformate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to human health
Hazard Classes and CategoriesAcute Tox. 4 (17.5%)

안전 데이터

wgk
3
tsca
No
rtecs
LQ6250000
ridadr
UN 3261 8/PG 2
HS 번호
29159020
risk_code
34-20/21/22

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 1건

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

응용 분야 · 3건

개요9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines[2].

용도9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).

일반 설명Fmoc chloride is a derivatizing agent.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
新乡市巨源生物科技有限公司373-5071400 13937360405 · [email protected]

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