기본 정보
- CAS
29560-58-5- 표준 SMILES
CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2.Cl- InChIKey
GAQAKFHSULJNAK-UHFFFAOYSA-N- 분자식
- C22H26ClN3O4S
- 평균 분자량
- 464 g/mol
- 단동위원소 질량
- 463.1332552
개요
Moricizine Hydrochloride is the hydrochloride salt form of moricizine, a phenothiazine analog with class I antiarrhythmic activity. Moricizine hydrochloride blocks the rapid flow of sodium ions into the myocardial cell during phase 0 of the action potential. This decreases excitability, slows the impulse conduction through the atrioventricular (AV) node and depresses depolarization.
이름 및 식별자
- 우선 이름
- Ethmozine
- IUPAC
- ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride
- 현지명
- 모라시진염화물
- 영어명
- Moracizine hydrochloride
- 분자식
- C22H26ClN3O4S
- 분자량
- 463.98
이름 및 동의어
MORICIZINE HYDROCHLORIDE29560-58-5EthmozineMoracizine hydrochlorideMoricizine HClEthmozinEtmozinDTXSID104778671OK3Z1ESPMoricizine hydrochloride (USP)Moricizine hydrochloride [USP]DTXCID1027766
이름 더 보기
모라시진염화물en313MORACIZINE HCLMoricizine Hydrochloride (250 mg)Moricizine Hydrochloride (1446950)ethyl10-(3-morpholinopropionyl)phenothiazine-2-carbamatehydrochloride
Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate hydrochlorideEthyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate hydrochlorideCHEBI:60937RefChem:56790Hydrochloride, MoricizineCarbamic Acid,(10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, Ethyl Ester, MonohydrochlorideMoricizine (Hydrochloride)Ethmosine
데이터베이스 식별자
- CAS
29560-58-5- PubChem CID
- 34632
- DTXSID
DTXSID1047786- ChEMBL
CHEMBL1200334
물성
구조 계산 물성
- 극성 표면적
- 96.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 31
- 형식 전하
- 0
- 복잡도
- 601
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 189 ° · 189° (dec)
- 물리적 상태
- Solid
- 색상
- Off-white to light brown
- 주요 응용
- 의약품(소분자)
- InChI
- 1S/C22H25N3O4S.ClH/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24;/h3-8,15H,2,9-14H2,1H3,(H,23,27);1H
- InChIKey
- GAQAKFHSULJNAK-UHFFFAOYSA-N
- SMILES
- S1c2c(cc(cc2)NC(=O)OCC)N(c4c1cccc4)C(=O)CC[N+H]3CCOCC3.[Cl-]
- EPA
- Moricizine hydrochloride (29560-58-5)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Moricizine hydrochloride
Ambiguous-DILI-concern
5
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- WGK 1
- tsca
- TSCA listed
- 독성
- LD50 in mice, rats (mg/kg): 36, 12 i.v.; in mice (mg/kg): 131 i.p. (Kaverina)
- HS 번호
- 2934302700
- Hazard Classifications
- Acute Tox. 4 Oral
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
용도 및 제조
General Manufacturing InformationCarbamic acid, N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-, ethyl ester, hydrochloride (1:1): INACTIVE
응용 분야
개요Moricizine hydrochloride is a phenothiazine derivative with antiarrhythmic activity developed by the Soviet Academy of Medical Sciences. It is licensed to Dupont-Sanko in a joint venture. Moricizine hydrochloride is the first drug licensed to a U.S. company by the Soviet Union and was introduced by Dupont in the U.S. in 1990 for specific use in Iife-threatening ventricular arrhythmias. This narrow indication reflects its proarrhythmic potential. The incidence of this adverse reaction, however, is lower than that of other antiarrhythmic agents.
용도Cardiac depressant (anti-arrhythmic).
상·하류 제품 정보
상류 원료
관련 반응
1건
화합물 노트
불러오는 중…