Gentamicin
겐타마이신 · GENTAMYCIN · GENTAMYCINE · 2-[4,6-Diamino-3-[3-amino-6-(1-methylaminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol · Gentacycol · GENTAMICINUM · GentamysinsolutionforBiochemistry · Gentavet
식별자 및 물리적 특성
| CAS No. | 1403-66-3 |
|---|---|
| 분자식 | C21H43N5O7 |
| 평균 분자량 | 477.6 g/mol |
| SMILES | CNC(C)C1CCC(N)C(OC2C(N)CC(N)C(OC3OCC(C)(O)C(NC)C3O)C2O)O1 |
| InChIKey | CEAZRRDELHUEMR-UHFFFAOYSA-N |
| PubChem CID | 3467 |
| ChEMBL | CHEMBL329592 |
| EC No. | 215-765-8 |
화학 및 물리적 성질
| XLogP | -4.1 |
|---|---|
| 극성 표면적 | 200 |
| 수소 결합 공여자 수 | 8 |
| 수소 결합 수용자 수 | 12 |
| 회전 가능 결합 수 | 7 |
| 무거운 원자 수 | 33 |
| 형식 전하 | 0 |
| 복잡도 | 636 |
| 물질 분류 | Other Uses -> Pharmaceuticals |
| 의약품 | Pharmaceuticals |
| LogP(분배 계수) | -3.1 |
| Color/Form | White amorphous powder |
| 용해도 | Freely soluble in waterSoluble in pyridine, dimethylformamide, in acidic media with salt formationmoderately soluble in methanol, ethanol, acetonepractically insoluble in benzene, halogenated hydrocarbons1.26e+01 g/L |
| Human Drugs | Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntibacterial AgentsAminoglycosidesAccess group antibiotics |
| Animal Drugs | Active Ingredients (Gentamicin) -> FDA GreenbookPharmaceuticals -> Animal Drugs -> Approved in Taiwan |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating fumes.Melts with decomposition between 220 °C and 240 °C. /Gentamycin sulfate/ |
| 녹는점 | 102-108 °C105 °C (decomposition)102-108° |
| Optical Rotation | Specific optical rotation: +146 deg at 25 °C/D |
| Physical Description | Solid |
| Stability/Shelf Life | Stable in light, air, and heat /Gentamycin sulfate/ |
| 밀도 | 1.000 g/cm3 |
| pKa(산도 계수) | pKa 8.2(66% DMF) (Uncertain)7.9(H2O) (Uncertain) |
| 물리적 상태 | powder |
| 색상 | Colorless to light yellow |
| 냄새 | Odorless |
| EPA | Gentamicin (1403-66-3) |
화학적 성질
Amorphous solid. Freely soluble in water, pyridine, acid solutions; moderately soluble in methanol, ethanol, and acetone; practically insoluble in benzene and halogenated hydrocarbons.
안전 및 규제
| GHS 분류 | DangerH317 (47.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 103 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Gentamicin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| 기타 안전 정보 | IMAP assessments - Gentamicin: Environment tier I assessment |
| 유해성 요약 | Allergic contact dermatitis reported, but raregentamycin cross reacts with neomycin, so positive patch test may reflect neomycin as the primary sensitizer[Marks, p.194-5] |
| FDA 요건 | The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including gentamicin sulfate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Gentamicin sulfate/The Generic Animal Drug and Patent Restoration act requires that each sponsor of an approved animal drug must submit to the FDA certain information regarding patents held for the animal drug or its method of use. The Act requires that this information, as well as a list of all animal drug products approved for safety and effectiveness, be made available to the public. Gentamicin sulfate is included on this list. /Gentamicin sulfate/Oral dosage form new animal drugs. Gentamicin sulfate oral solution. ... Indications for use. In weanling swine for control and treatment of colibacillosis caused by strains of Escherichia coli sensitive to gentamicin, and in swine for control and treatment of swine dysentery associated with Treponema hyodysenteriae. ... Limitations. Do not slaughter treated swine for food for at least 3 days following treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. /Gentamicin sulfate/Oral dosage form new animal drugs. Gentamicin sulfate pig pump oral solution. ... Indications for use. In neonatal swine 1 to 3 days of age for control and treatment of colibacillosis caused by strains of Escherichia coli sensitive to gentamicin. ... Limitations. For use in neonatal swine only. Do not slaughter treated swine for food for at least 14 days following treatment. /Gentamicin sulfate/ |
용도
개요
Gentamicin is a mixture of several antibiotic components produced by fermentation of Mi cromonospora purpurea and other related soil microorganisms (hence its name is spelled with an “i” instead of a “ y”). Gentamicins C-1, C-2, and C-1a are most prominent. Gentamicin is the most important of the aminoglycoside antibiotics still in use. Gentamicin was, for example, one of the first antibiotics to have significant activity against Pseudomonas aeruginosa infections. This water-loving, opportunistic pathogen frequently is encountered in burns, pneumonias, and urinary tract infections.
용도
antibacterial