기본 정보
- CAS
6915-11-3- 표준 SMILES
COC1=CC(=O)CC(C)C12Oc1c(Cl)c(OC)cc(OC)c1C2=O- InChIKey
DDUHZTYCFQRHIY-UHFFFAOYSA-N- 분자식
- C17H17ClO6
- 평균 분자량
- 352.8 g/mol
- 단동위원소 질량
- 352.071366
개요
grifulvin V has been reported in Axinella verrucosa with data available.
이름 및 식별자
- 우선 이름
- Gris-peg
- IUPAC
- 7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione
- 현지명
- 그리세오풀빈
- 영어명
- griseofulvin
- 분자량
- 0
이름 및 동의어
Gris-PEG7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione7-chloro-3',4,6-trimethoxy-5'-methylspiro(1-benzofuran-2,4'-cyclohex-2-ene)-1',3-dioneRefChem:922504GRISEOFULVIN,ULTRAMICROSIZEGriseofulvin, ultramicrosize6915-11-37-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione78739-00-1GriseostatinGrisowenMLS000028436
이름 더 보기
그리세오풀빈Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl- (8CI, 9CI)
NSC34533SMR0000583177-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dionedl-GriseofulvinFulvicin Bolus7-Chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[[1]benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione7-chloro-4,6,12-trimethoxy-14-methylspiro[2-hydrobenzo[b]furan-2,4'-cyclohexan e]-11-ene-3,10-dioneC17H17ClO6
데이터베이스 식별자
- CAS
6915-11-3、78739-00-1
물성
구조 계산 물성
- XLogP
- 2.2
- 극성 표면적
- 71.1 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 24
- 형식 전하
- 0
- 복잡도
- 575
실험 및 물리화학적 성질
LogP2.33
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Exposure RoutesPoorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Toxicity Summary
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
Signs and SymptomsSide effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Carcinogen Classification2B, possibly carcinogenic to humans. (L135)
화학 및 산업
약리 정보
Metabolism/MetabolitesPrimarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.
Half Life: 9-21 hours
MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
용도 및 제조
Uses
Griseofulvin is used both in animals and in humans, to treat fungal infections of the skin (commonly known as ringworm) and nails. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. Griseofulvin is reserved for cases with nail, hair or large body surface involvement. (Wikipedia)
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…