구아네티딘 및 그 염류

구아네티딘및그염류 · Dopom · C07036 · Eutensol · Abapresin · Octatensine · guanethidine · guanethidine USP/EP/BP

식별자 및 물리적 특성

CAS No.	55-65-2
분자식	C10H22N4
평균 분자량	198.31 g/mol
단동위원소 질량	198.1844467 g/mol
SMILES	NC(N)=NCCN1CCCCCCC1
InChIKey	ACGDKVXYNVEAGU-UHFFFAOYSA-N
PubChem CID	3518
ChEMBL	CHEMBL765
ChEBI	CHEBI:5557
EC No.	200-241-3
DTXSID	DTXSID5023116
현지명	구아네티딘 및 그 염류

화학 및 물리적 성질

XLogP	0.5
극성 표면적	67.6
수소 결합 공여자 수	2
수소 결합 수용자 수	2
회전 가능 결합 수	3
무거운 원자 수	14
형식 전하	0
복잡도	167
의약품	Pharmaceuticals -> Listed in ZINC15
LogP(분배 계수)	0.8
용해도	Very solubleWHITE, CRYSTALLINE POWDERSTRONG CHARACTERISTIC ODORSPARINGLY SOL IN WATERSLIGHTLY SOL IN ALCPRACTICALLY INSOL IN CHLOROFORM /SULFATE/VERY SOL IN H2OINSOL IN NONPOLAR SOLVENTS /MONOSULFATE/2.25e+00 g/L
Human Drugs	Pharmaceuticals
Endocrine Disruptors	Potential endocrine disrupting compound
녹는점	276-281250 °C (sulfate salt)
Physical Description	Solid
Collision Cross Section	151.79 Å² [M+K]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
Other Experimental Properties	CRYSTALS FROM DIL ETHANOLMP 276-281 °C (DECOMP) /SULFATE/
끓는 점	325.64°C (rough estimate)
밀도	0.9402 (rough estimate)
굴절률	1.4910 (estimate)
저장 조건	Store at -20°C
pKa(산도 계수)	pKa 11.4 (Uncertain)

안전 및 규제

기타 안전 정보	IMAP assessments - Guanidine, [2-(hexahydro-1(2H)-azocinyl)ethyl]-: Environment tier I assessment
상호 작용	MONOAMINE OXIDASE INHIBITORS HAVE BEEN REPORTED TO ANTAGONIZE ANTIHYPERTENSIVE EFFECTS OF GUANETHIDINE.TOPICALLY ADMIN GUANETHIDINE ENHANCES RESPONSE OF EYE TO TOPICALLY ADMIN PHENYLEPHRINE, RESULTING IN INCR MYDRIASIS.THIAZIDES ENHANCE ANTIHYPERTENSIVE ACTION OF GUANETHIDINE, ALLOWING DOSE OF GUANETHIDINE TO BE REDUCED & DECR INCIDENCE OF ADVERSE REACTIONS...ANTIHYPERTENSIVE ACTION OF GUANETHIDINE MAY BE BLOCKED BY DEXTROAMPHETAMINE & RELATED COMPDTHEREFORE, CONCURRENT USE OF THESE DRUGS SHOULD BE AVOIDED.For more Interactions (Complete) data for GUANETHIDINE (10 total), please visit the HSDB record page.
Human Toxicity Excerpts	SOME TENDENCY TO DIARRHEA IS ASSOC WITH GUANETHIDINE THERAPY IN HIGH PERCENTAGE OF CASES... INHIBITION OF EJACULATION IS COMMON, & IMPOTENCE MAY BE PSCHOGENIC AFTERMATH. ...CAN CAUSE SEVERE HYPERTENSIVE REACTIONS IN PT WITH PHEOCHROMOCYTOMA.HYPOTENSIVE EPISODES MAY BE ASSOC WITH SYMPTOMS OF CEREBRAL & MYOCARDIAL ISCHEMIA. ... GENERALIZED SUBJECTIVE "WEAKNESS" IS COMMON... FLUID RETENTION OCCURS & CAN LEAD TO EDEMA & RESISTANCE TO ANTIHYPERTENSIVE EFFECT IF DIURETIC IS NOT GIVEN CONCURRENTLY. ...CAN LEAD TO...HEART FAILURE IN PT WITH LIMITED CARDIAC RESERVE.MOST IMPORTANT COMPLICATION OF GUANETHIDINE THERAPY IS POSTURAL HYPOTENSIONIT IS MOST PROMINENT SHORTLY AFTER ARISING FROM SLEEP & MAY BE ACCENTUATED BY HOT WEATHER, ALCOHOL, OR EXERCISE.APPLICATION OF 5%-10% GUANETHIDINE SULFATE SOLN TO EYES OF PT HAS INDUCED SLIGHT MIOSIS, NOTICEABLE PTOSIS & HYPEREMIA FROM ANTIADRENERGIC ACTION. ... 50% OF PT WITH THYROID DYSFUNCTION & EXOPHTHALMOS HAVE DEVELOPED SUPERFICIAL CHANGES IN CORNEAL EPITHELIUM AFTER 1-8 WK OF APPLYING SOLN TWICE DAY. /SULFATE/For more Human Toxicity Excerpts (Complete) data for GUANETHIDINE (9 total), please visit the HSDB record page.
Drug Induced Liver Injury	Benchmark Dataset for the Liver Toxicity Knowledge Base (LTKB)guanethidineIsmelin®AntiadrenergicsNot Applicableno-DILI-concern
독성	LD50 oral in rat: 1050mg/kg

용도

개요

Guanethidine is used for severe hypertension when the use of the more generally accepted drugs turns out to be unsuccessful. It is a powerful, long-lasting antihypertensive drug; however, it affects a patient’s blood pressure only in the orthostatic position, and not when lying down. Guanethidine is a very powerful and long-lasting drug, and its action often lasts 2–3 days after its use has been stopped.

용도

Guanethidine is used for severe hypertension, where use of more universally accepted drugs is not successful. It is a very powerful and long-lasting drug, and its effects last for 2–3 days after using it.

용도

Antihypertensive.

일반 설명

Guanethidine or guanethidinesulfate [C10H22N4·H2SO4].