Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
메타크릴로일옥시에틸 이소시아네이드
메타크릴로일옥시에틸아이소시아네이트 · 메타크릴로일옥시에틸이소시아네이드 · 메타크릴로일옥시에틸아이소시아네이트(METHACRYLOYLOXYETHYLISOCYANATE) · MOI · iem · ISOCYANATOETHYL METHACRYLATE · Karenz MOI · 2-Isocyanatoethyl
식별자 및 물리적 특성
| CAS No. | 30674-80-7 |
|---|---|
| 분자식 | C7H9NO3 |
| 평균 분자량 | 155.15 g/mol |
| 단동위원소 질량 | 155.05824315 g/mol |
| SMILES | C=C(C)C(=O)OCCN=C=O |
| InChIKey | RBQRWNWVPQDTJJ-UHFFFAOYSA-N |
| PubChem CID | 35409 |
| EC No. | 250-284-7 |
| DTXSID | DTXSID6051986 |
| 현지명 | 메타크릴로일옥시에틸 이소시아네이드 |
화학 및 물리적 성질
| XLogP | 2.3 |
|---|---|
| 극성 표면적 | 55.7 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 5 |
| 무거운 원자 수 | 11 |
| 형식 전하 | 0 |
| 복잡도 | 204 |
| 물질 분류 | Toxic Gases & Vapors -> Monoisocyanates |
| Physical Description | Methacryloyloxyethyl isocyanate is a liquid. (EPA, 1998)Colorless liquid with a peppery odor[CHEMINFO] |
| Other Experimental Properties | Compound is stable in moist air for up to 5.2 hours at 5% and 2.6 hours at 50% RH.Compound is readily hydrolyzed in dilute water solution. |
| 녹는점 | -45 °C (lit.) |
| 끓는 점 | 211 °C (lit.) |
| 밀도 | 1.098 g/mL at 25 °C (lit.) |
| 증기압 | 18Pa at 20℃ |
| 굴절률 | n20/D 1.45(lit.) |
| 인화점 | 207 °F |
| 저장 조건 | 2-8°C |
| 물리적 상태 | 투명한 액체 |
| 색상 | 무색 내지 거의 무색 |
| 용해도 | 4.214g/L at 25℃ |
| InChI | InChI=1S/C7H9NO3/c1-6(2)7(10)11-4-3-8-5-9/h1,3-4H2,2H3 |
| InChIKey | RBQRWNWVPQDTJJ-UHFFFAOYSA-N |
| SMILES | C(OCCN=C=O)(=O)C(C)=C |
| LogP(분배 계수) | 1.72 |
| EPA | Methacryloyloxyethyl isocyanate (30674-80-7) |
화학적 성질
Colorless liquid
안전 및 규제
| GHS 분류 | DangerH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P233, P260, P261, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 53 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| 규제 정보 | Chemical: 2-Propenoic acid, 2-methyl-, 2-isocyanatoethyl esterStatus: Active Update: 20-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/5762The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 운송 라벨(DOT) | Poison |
| 화재 위험 | (Non-Specific -- Isocyanates and Solutions, n.o.s. (Flammable, Poisonous)) May be ignited by heat, sparks, or flames. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff from fire control or dilution water may cause pollution. (EPA, 1998) |
| 건강 유해성 | (Non-Specific -- Isocyanates and Solutions, n.o.s. (Flammable, Poisonous)) Poisonousmay be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. (EPA, 1998) |
| 유해성 요약 | May cause eye injury and skin burnsInhalation of high concentrations may cause pulmonary edema although this effect has not been reported in the workplace. [CHEMINFO] |
| 반응성 그룹 | Isocyanates and Isothiocyanates |
| TSCA 요건 | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, use, and exposure to EPA as cited in the preamble in 51 FR 41329.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 2-Propenoic acid, 2-methyl-,2-isocyanatoethyl ester is included on this list. |
| Reactivity Alerts | Polymerizable |
| Reactivity Profile | Isocyanates and thioisocyanates, such as METHACRYLOYLOXYETHYL ISOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. |
| Air and Water Reactions | No rapid reaction with air. No rapid reaction with water. |
| Highly Hazardous Substance | Chemical: Methacryloyloxyethyl Isocyanate |
| CERCLA 보고 수량 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Methacryloyloxyethyl isocyanate is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 lbs. |
| 소화 | (Non-Specific -- Isocyanates and Solutions, n.o.s. (Flammable, Poisonous)) Keep unnecessary people awayisolate hazard area and deny entry. Stay upwindkeep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area if you can do it without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. Fight fire from maximum distance. Dike fire control water for later disposaldo not scatter the material. |
| 응급 처치 | Warning: Methacryloyloxyethyl isocyanate is an irritant. |
| 비화재 누출 대응 | (Non-Specific -- Isocyanates and Solutions, n.o.s. (Flammable, Poisonous)) Keep unnecessary people awayisolate hazard area and deny entry. Stay upwindkeep out of low areas. Ventilate closed spaces before entering them. Shut off ignition sourcesno flares, smoking or flames in hazard area. Do not touch spilled materialstop leak if you can do so without risk. Use water spray to reduce vapors. |
| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
| Isolation and Evacuation | Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: |
| Protective Action Criteria (PAC) | 0.0091 [ppm]0.10 [ppm]1.0 [ppm] |
| Personal Protective Equipment (PPE) | For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998) |
| Emergency Response Planning Guidelines | ERPG-1: Insufficient data - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA] |
| Other Standards Regulations and Guidelines | Emergency Response Planning Guidelines (ERPG): ERPG(1) Not appropriateERPG(2) 0.1 ppm (without serious, adverse effects) for up to 1 hr exposureERPG(3) 1 ppm (not life threatening) up to 1 hr exposure. |
| Treatment | Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered. (L97) |
| 건강 영향 | Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97) |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 노출 경로 | Oral (L96)inhalation (L96)dermal (L96) |
| 독성 요약 | Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97) |
| Signs and Symptoms | Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness, giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (L96, L97) |
| Human Toxicity Excerpts | Isocyanates are irritating to the skin and the mucous membranes, the skin conditions ranging from localized itching to more or less widespread eczema. Eye affections are less common and, although lacrimation is often found, conjunctivitis is rare. The commonest and most serious troubles, however, are those affecting the respiratory systems. /Isocyanates/ |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Non-Human Toxicity Excerpts | Guinea pigs were exposed to daily induction exposures with an aerosol of bovine serum albumin (BSA) or bovine serum albumin conjugated with isocyanatoethyl methacrylate (IEM) or isocyanatoethyl propionate (IEP). After approx 2 wk significant incr in respiratory rate occurred in the guinea pigs exposed to the isocyanate conjugates. The number of animals responding was related to the degree of conjugation of isocyanate to protein. The isocyanates conjugated to another carrier, guinea pig serum albumin (GSA), elicited responses. In guinea pigs responding to bovine serum albumin-isocyanatoethyl methacrylate, 0.01 ppm isocyanatoethyl methacrylate monomer did not elicit responses0.1-0.4 ppm isocyanatoethyl methacrylate vapor elicited responses similar to conjugates but which were delayed0.5 and 0.6 ppm induced irritation responses. Guinea pigs developing responses to either of the isocyanate conjugates displayed cross-reactions to challenge with the other. Application of bovine serum albumin-isocyanatoethyl propionate or isocyanatoethyl propionate monomer to the scratched skin of guinea pigs that responded by inhalation to bovine serum albumin-isocyanato propionate resulted in immediate wheal and flare responses not seen in unexposed animals.The dominant lethal test was used to evaluate the mutagenic potential of isocyanatoethyl methacrylate in rats. Male Sprague-Dawley rats were exposed to 0, 25, 80, or 250 ppb of isocyanatoethyl methacrylate by inhalation for 6 hr/day for 10 wk (one spermatogenic cycle). After the exposure period, the males were bred with untreated virgin female rats. At approx mid-gestation, the females were sacrificed and the number of corpora lutea, implantations and resorptions were recorded. Statistical analysis of these data indicated that the treated males were comparable to control males in all reproductive parameters evaluated. Isocyanatoethyl methacrylate did not affect male fertility or produce dominant lethal mutations in male rats. |
| Antidote and Emergency Treatment | Noncardiogenic pulmonary edema and bronchospasm are the most immediate serious clinical consequences of isocyanate exposure. Markedly symptomatic patients should receive oxygen, ventilatory support, and an intravenous line. Treatment for asthma includes inhaled sympathomimetics (salbutamol, metaproterenol), intravenous theophylline, parenteral sympathomimetics (epinephrine, terbutaline), and steroids. /Isocyanates/Most treatment is symptomatic. Mydriatics, systemic analgesics, and topical antibiotics (Sulamyd) may be used for corneal abrasions. There is no effective therapy for sensitized workers, and these people should be moved to a work site devoid of exposure to isocyanates. /Isocyanates/ |
| Toxicity Data | LC50 (rat) = 4 ppm/6H |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | OZ4950000 |
| 운송 번호(UN) | UN 2206 6.1/PG 3 |
| 독성 | rat,LC50,inhalation,4ppm/6H (4ppm),Drug and Chemical Toxicology. Vol. 3, Pg. 381, 1980. |
| 관세 코드 | 29291090 |
| 위험 문구(R) | 21/22-26-37/38-41-42-42/43-36/37/38-23-22 |
| 위험 표시 | T+,T |
| 안전 문구(S) | 26-36/37/39-45-36/37-23 |
| 포장분류 | II |
| 위험 등급 | 6.1(a)Acute Tox. 1 InhalationAcute Tox. 4 OralEye Dam. 1Resp. Sens. 1Skin Irrit. 2Skin Sens. 1 |
| 기존화학 물질 | 2009-3-3936 |
| 저장 분류 | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| 유해 물질 데이터 | 30674-80-7(Hazardous Substances Data) |
용도
용도
A latent cross-linker for resins.1
일반 설명
Liquid.