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Haloprogin

HCID 3561
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
777-11-7
표준 SMILES
Clc1cc(Cl)c(OCC#CI)cc1Cl
InChIKey
CTETYYAZBPJBHE-UHFFFAOYSA-N
분자식
C9H4Cl3IO
평균 분자량
361.4 g/mol
단동위원소 질량
359.83725

개요

Haloprogin is an aromatic ether.

이름 및 식별자

우선 이름
Haloprogin
IUPAC
1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene
영어명
HALOPROGIN
분자식
C9H4Cl3IO
분자량
361.39

이름 및 동의어

haloprogin777-11-7HalotexMycandenMycilanPolikHaloprogineHaloproginaM-1028 (Meiji)HaloproginumNSC-1000713-Iodo-2-propynyl 2,4,5-trichlorophenyl ether
이름 더 보기
m1028FungaclorHALOPROGIN (200 MG)
DTXSID9046865AIU7053OWL1,2,4-Trichloro-5-((3-iodoprop-2-yn-1-yl)oxy)benzeneM-10281,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzeneBenzene, 1,2,4-trichloro-5-((3-iodo-2-propynyl)oxy)-NSC100071DTXCID7026865

데이터베이스 식별자

CAS
777-11-7
PubChem CID
3561
DTXSID
DTXSID9046865
ChEMBL
CHEMBL1289
ChEBI
CHEBI:5614
UNII
AIU7053OWL
EC Number
212-286-6
Nikkaji
J3.326J

물성

구조 계산 물성

XLogP
4.6
극성 표면적
9.2 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
1
회전 가능 결합 수
2
무거운 원자 수
14
형식 전하
0
복잡도
247

실험 및 물리화학적 성질

Drugs · 2건

Pharmaceuticals -> Antibiotics

Pharmaceuticals -> Listed in ZINC15

LogP5.3
Solubility6.01e-03 g/L
Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point · 2건

114-115

113.5 °C

Physical DescriptionSolid

물리화학적 성질

녹는점
113 · 113-114°
끓는 점
477.49 °C · 477.49°C (rough estimate)
밀도
1.935 · 1.9350 (estimate)
물리적 상태
Solid
색상
White to off-white

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Warning

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

유해성 정보

Hazard Classes and CategoriesEye Irrit. 2 (100%)

안전 데이터

rtecs
KO1225000
독성
LD50 in mice: >3 g/kg orally and s.c.; 510 mg/kg i.p. (Seki, 1963)
risk_code
22-36/37/38
hazard_code
Xn
safety_code
26-36

화학 및 산업

약리 정보

ATC Code · 2건

D - Dermatologicals

QD - Dermatologicals

Pharmacodynamics · 1건

Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).

Mechanism of Action · 1건

Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with haloprogin, including irritation, burning, vesiculation (blisters), scaling, and itching. It is generally used when the infection is unresponsive to other antifungals.

MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Cellular LocationsMembrane
응용 분야 · 2건

용도Antibacterial.

일반 설명3-Iodo-2-propynyl-2,4,5-trichlorophenyl ether (Halotex)crystallizes as white to pale yellow forms that are sparinglysoluble in water and very soluble in ethanol. It is an etherealderivative of a phenol. Haloprogin is used as a 1% cream forthe treatment of superficial tinea infections.Formulations of haloprogin should be protected fromlight because the compound is photosensitive. Haloprogin isavailable as a solution and a cream, both in a 1% concentration.Haloprogin is probably not the first topical agent thatshould be recommended. Although the cure rates for topicalfungal infections are relatively high, they come at a highprice. The lesion typically worsens before it improves.Inflammation and painful irritation are common.

상·하류 제품 정보

상류 원료

프로파길브로마이드2,4,5-트리클로로페놀염화구리(Ⅰ)아이오딘

공급사19 곳

上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
Shanghai Scibiotron Pharmaceutical Co., Ltd+86-16621589600 · [email protected]
上海昶衍化工科技有限公司021-20242659 18930833303 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
杭州六可生物科技有限公司+86-0571-86912261 +86-15658003402 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
上海鑫矽新材料有限公司13585834793 13660927110 · [email protected]
河北贞佳新材料有限公司0319-5925599 13315915972 · [email protected]
上海芮晖化工科技有限公司021-31433387 15618786686 · [email protected]
上海琼燕医药科技有限公司086-021-15821262312 15821262312 · [email protected]
陕西缔都医药化工有限公司029-029-029-81148696 18161915376 · [email protected]
TargetMol中国(陶术生物)4008200310 15002144251 · [email protected]
SHANGHAI YOUNG-CHEM CHEMICAL CO., LTD.13817489192 · [email protected]
重庆卡兰医药有限公司[email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
Dideu Industries Group Limited+86-29-81148696 +86-15129568250 · [email protected]

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