기본 정보
- CAS
31352-82-6- 표준 SMILES
Cc1nn(C)c2c1C(c1ccccc1F)=NCC(=O)N2C- InChIKey
GDSCFOSHSOWNDL-UHFFFAOYSA-N- 분자식
- C15H15FN4O
- 평균 분자량
- 286.3 g/mol
- 단동위원소 질량
- 286.12298928
개요
Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.
이름 및 식별자
- 우선 이름
- Zolazepam
- IUPAC
- 4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[5,4-e][1,4]diazepin-7-one
- 현지명
- 졸라제팜
- 영어명
- Zolazepam
- 분자식
- C15H15FN4O
- 분자량
- 286.309
이름 및 동의어
ZOLAZEPAM31352-82-6ZolazepamumCI 716G1R474U58UPyrazolo(3,4-e)(1,4)diazepin-7(1H)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-DTXSID30185278ZolasepamRefChem:196213DTXCID401077694-(2-fluorophenyl)-1,3,8-trimethyl-1H,6H,7H,8H-pyrazolo(3,4-e)(1,4)diazepin-7-oneFlupyrazapon
이름 더 보기
졸라제팜CL-7164-(o-Fluorophenyl)-6,8-dihydro-1,3,8-triMethylpyrazolo[3,4-e][1,4]diazepin-7(1H)-one4-(2-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-e][1,4]diazepin-7(1H)-one4-(2-Fluorophenyl)-6,8-dihydro-1,3,8-triMethylpyrazolo[3,4-e][1,4]diazepin-7(1H)-one-d3Pyrazolo[3,4-e][1,4]diazepin-7(1H)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-
Zolazepam [INN:BAN]Zolazepamum [INN-Latin]UNII-G1R474U58UDEA No. 72954-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one4-(2-Fluorophenyl)-1,3,8-trimethyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-one4-(2-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo-(3,4-e)(1,4)diazepin-7(1H)-oneZOLAZEPAM [INN]
물성
구조 계산 물성
- XLogP
- 1.7
- 극성 표면적
- 50.5 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 455
실험 및 물리화학적 성질
Drugs
DEA NFLIS-Drug Category -> Benzodiazepines
Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds
Animal Drugs
Pharmaceuticals -> UK Veterinary Medicines Directorate List
Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
Collision Cross Section162.3 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
물리화학적 성질
- 녹는점
- 183 · 183-185 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
- 끓는 점
- 506.6 · 506.6±50.0 °C(Predicted)
- 밀도
- 1.31 · 1.31±0.1 g/cm3(Predicted)
- 용해도
- 1 mg/ml; · DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 1.85 · 1.85±0.20(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H315
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
용도 및 제조
Use ClassificationPharmaceuticals -> Animal Drugs -> Approved in Taiwan
응용 분야
용도A sedative and anesthetic
공급사13 곳
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
VladaChem GmbH+49-7246-3082843 +86-18411632868 · [email protected]
Syntechem Co.,Ltd[email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
上海陶术生物科技股份有限公司
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