기본 정보
- CAS
32672-69-8- 표준 SMILES
CN1CCCCC1CCN1c2ccccc2Sc2ccc(S(C)=O)cc21.O=S(=O)(O)c1ccccc1- InChIKey
CRJHBCPQHRVYBS-UHFFFAOYSA-N- 분자식
- C27H32N2O4S3
- 평균 분자량
- 544.8 g/mol
- 단동위원소 질량
- 544.15242103
개요
Mesoridazine besylate is the benzenesulfonate salt of mesoridazine prepared using equimolar amounts of mesoridazine and benzenesulfonic acid. It has a role as a dopaminergic antagonist and a first generation antipsychotic. It contains a mesoridazine.
이름 및 식별자
- 우선 이름
- Mesoridazine Besylate
- IUPAC
- benzenesulfonic acid;10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfinylphenothiazine
- 영어명
- Mesoridazine Besylate
- 분자식
- C27H32N2O4S3
- 분자량
- 544.75
이름 및 동의어
MESORIDAZINE BESYLATE32672-69-8Mesoridazine benzenesulfonatemesoridazine besilateNC 12310-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylsulfinyl)-10H-phenothiazine benzenesulfonateNSC-760073UNII-T4G2I958J2T4G2I958J2Mesoridazine besylate (USP)Mesoridazine besylate [USP]10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine monobenzenesulfonate
이름 더 보기
nc123SERENTILMesoridazine Besylate (250 mg)Mesoridazine Besylate (1393005)Mesoridazine Besilate (10-[2-[(2RS)Mesoridazine Besylate, 10 mM in DMSOylsulfinyl)ethyl)-10h-phenothiazine(1:1)Mesoridazine benzenesulfonate|||Serentil
CHEBI:6781mesoridazine monobenzenesulfonatethioridazine-2-sulfoxide besylate(+-)-10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine monobenzenesulfonateNSC 76007310H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-, (+-)-, monobenzenesulfonateMESORIDAZINE BESILATE (MART.)MESORIDAZINE BESILATE [MART.]
물성
구조 계산 물성
- 극성 표면적
- 131 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 36
- 형식 전하
- 0
- 복잡도
- 686
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 174 · 174-175 °C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 10 mg/mL · DMSO: 10mg/mL
- 물리적 상태
- 고체
- 색상
- 하얀색
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChIKey
- CRJHBCPQHRVYBS-UHFFFAOYSA-N
- SMILES
- OS(=O)(=O)c1ccccc1.CN2CCCCC2CCN3c4ccccc4Sc5ccc(cc35)S(C)=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Other Safety InformationIMAP assessments - Benzenesulfonic acid, compound with 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine (1:1): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Mesoridazine besylate
Ambiguous-DILI-concern
5
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 3
- rtecs
- DB7176700
- 독성
- LD50 in mice (mg/kg): 33 i.v.; 611 s.c.; 346 orally (Maruyama)
- HS 번호
- 2934302300
- risk_code
- 22
- hazard_code
- Xn
- Hazard Classifications
- Acute Tox. 4 Oral
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도antpsychotic
일반 설명Mesoridazine besylate,10-[2-(methyl-2-piperidyl)ethyl]-2-(methylsulfinyl)phenothiazinemonobenzenesulfonate (Serentil), shares manyproperties with thioridazine. However, no pigmentaryretinopathy has been reported.
상·하류 제품 정보
상류 원료
공급사26 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
玺标（上海）科技有限公司18512111473 18512111473 · [email protected]
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