데이터를 보충하는 중입니다. 잠시 후 페이지를 새로 고치면 최신 내용을 볼 수 있습니다
기본 정보
- CAS
118-42-3- 표준 SMILES
CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12- InChIKey
XXSMGPRMXLTPCZ-UHFFFAOYSA-N- 분자식
- C18H26ClN3O
- 평균 분자량
- 335.879 g/mol
- 단동위원소 질량
- 335.17644013
이름 및 식별자
- 우선 이름
- Hydroxychloroquine
- IUPAC
- 2-[{4-[(7-Chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethan-1-ol
- 영어명
- Hydroxychloroquine
- 분자식
- C18H26ClN3O
- 분자량
- 335.88
이름 및 동의어
hydroxychloroquineHCQplaquenilHydroychloroquineHydroxychloroquine base7-chloro-4-(4-(n-ethyl-n-beta-hydroxyethylamino)-1-methylbutylamino)quinolinC07043win1258OxychlorochinOxychloroquine
데이터베이스 식별자
- CAS
118-42-3- PubChem CID
- 3652
- DTXSID
DTXSID8023135- ChEMBL
CHEMBL1535- ChEBI
CHEBI:5801- UNII
- 4QWG6N8QKH
- EC Number
- 204-249-8
- Nikkaji
- J5.298A
물성
물리화학적 성질
- 녹는점
- 89 · 89-91°
- 끓는 점
- 516.7 · 516.7±50.0 °C(Predicted)
- 밀도
- 1.1438 · 1.1438 (rough estimate)
- 굴절률
- 1.579 · 1.5790 (estimate)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름 (약간 용해됨), DMSO (약간 용해됨), 메탄올 (약간 용해됨)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 14.76 · 14.76±0.10(Predicted)
- 색상
- 흰색에서 황백색까지
- BCS Class
- 2 · 2
- InChI
- InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
- InChIKey
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N
- SMILES
- C(O)CN(CCCC(NC1=C2C(=NC=C1)C=C(Cl)C=C2)C)CC
- NIST
- Hydroxychloroquine(118-42-3)
- EPA
- 2 · Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]- (118-42-3)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 1
- 독성
- child,LDLo,oral,600mg/kg (600mg/kg),BRAIN AND COVERINGS: INCREASED INTRACRANIAL PRESSUREBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDCARDIAC: OTHER CHANGES,Journal of Analytical Toxicology. Vol. 14, Pg. 186, 1990.
- Hazard Classifications
- Acute Tox. 4 Oral
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
역사Chloroquine was discovered by Hans Andersag and coworkers at the Bayer laboratories in 1934. It is a a synthetic analogue with the same mechanism of action with quinine. This was introduced into clinical practice in 1947 for the prophylactic treatment of malaria. Researchers subsequently attempted to discover structural analogs with superior properties and one of these was hydroxychloroquine.
용도Hydroxychloroquine is used to treat autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, in addition to malaria.Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.Hydroxychloroquine is used to treat:rheumatoid arthritisdiscoid and systemic lupus erythematosus (SLE)juvenile idiopathic arthritis (JIA).Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits.
상·하류 제품 정보
상류 원료
관련 반응
2건
화합물 노트
불러오는 중…