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HCID 36613생성일: 2026년 11월 2일

2,7-디클로로디벤조-P-디옥신

2,7-디클로로디벤조-P-디옥신 · Dcdd · 2,7-DCDD · NCI-C03667 · caswellno302ab · 2,7-Dichlorooxanthrene · 2,7-Dichlorodibenzodioxin · 2,7-dichloro-dibenzo-p-dioxi

https://huagongshe.com/ko/chemical/36613

2,7-디클로로디벤조-P-디옥신 분자 구조식

식별자 및 물리적 특성

CAS No.33857-26-0
분자식C12H6Cl2O2
평균 분자량253.08 g/mol
단동위원소 질량251.9744848 g/mol
SMILESClc1ccc2c(c1)Oc1ccc(Cl)cc1O2
InChIKeyNBFMTHWVRBOVPE-UHFFFAOYSA-N
PubChem CID36613
DTXSIDDTXSID1020435
현지명2,7-디클로로디벤조-P-디옥신

화학 및 물리적 성질

XLogP4.3
극성 표면적18.5
수소 결합 공여자 수0
수소 결합 수용자 수2
회전 가능 결합 수0
무거운 원자 수16
형식 전하0
복잡도235
PolymersOther Classes -> Halogenated Polyaromatics
SpringerMaterials PropertiesBoiling point
LogP(분배 계수)5.7
Color/FormCOLORLESS CRYSTALS
용해도less than 1 mg/mL at 66 °F (NTP, 1992)Water solubility of roughly 0.19 ppm (estimated)
녹는점394 to 396 °F (NTP, 1992)209-210 °C201°C
증기압0.0000009 [mmHg]1.125X10-6 mm Hg at 25 °C
Physical Description2,7-dichlorodibenzo-p-dioxin appears as colorless crystals or a white powder. (NTP, 1992)Colorless solid[HSDB] White solid[MSDSonline]
Stability/Shelf LifeEXTREMELY STABLE, EVEN ON HEATING TO 700 °C /CHLORODIBENZO-PARA-DIOXINS/
끓는 점328.83°C (rough estimate)
밀도1.4710 (estimate)
굴절률1.6430 (estimate)
용해도3.75ug/L(25℃)
헨리 상수1.7×10-1 mol/(m3Pa) at 25℃, Santl et al. (1994)
안정성안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
EPA2,7-Dichlorodibenzo-p-dioxin (33857-26-0)

화학적 성질

colourless crystals or white powder

안전 및 규제

운송 라벨(DOT)Class 9
화재 위험Flash point data are not available for this chemical. It is probably combustible. (NTP, 1992)
건강 유해성SYMPTOMS: Symptoms of exposure to this chemical may include chloracne, porphyria and irreversible liver damage.
유해성 요약IARC classification is for polychlorinated dibenzo-para-dioxins other than 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)Polychlorodibenzodioxins have caused chloracne in humans[HSDB] May cause chloracne, porphyria, and liver injury[CAMEO]
반응성 그룹Ethers
Special ReportsWHOEnviron Health Criteria 88: Polychlorinated Dibenzo-para-dioxins and Dibenzofurans p.262 (1989)Skene SA et alHum Toxicol 8 (3): 173-204 (1989). Polychlorinated Dibenzo-P-Dioxins and Polychlorinated DibenzofuransThe Risk to Human Health A review.DHEW/NCIBioassay of 2,7-Dichlorodibenzo-p-dioxin (DCDD) for Possible Carcinogenicity p.vii (1979) Technical Rpt Series No. 123 DHEW Pub No. (NIH) 79-1378
Air and Water ReactionsInsoluble in water.
소화Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
비화재 누출 대응SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

용도

용도

2,7-Dichlorodibenzo-p-dioxin is a standard used in environmental testing and research and in the study of enthalpy of vaporization of ersistant organic pollutants.

일반 설명

Colorless crystals or a white powder.

Isolation and EvacuationExcerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
Minimum Risk LevelAcute Oral: 0.0002 ug/kg/day (L134) Intermediate Oral: 0.00002 ug/kg/day (L134) Chronic Oral: 0.000001 ug/kg/day (L134)
Personal Protective Equipment (PPE)RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
TreatmentTreatment of CDD exposure may include washing the area of contact, GI decontamination, administering an IV, or forced alkaline diuresis. (L346)
상호 작용DICHLORODIBENZODIOXIN APPEARED TO PROMOTE SKIN CARCINOGENESIS INDUCED IN MICE BY DIMETHYLBENZANTHRACENE. /DICHLORODIBENZODIOXIN/
건강 영향Exposure to large amounts of CDDs causes chloracne, a severe skin disease with acne-like lesions that occur mainly on the face and upper body. CDDs may also cause liver damage and induce long-term alterations in glucose metabolism and subtle changes in hormonal levels. In addition, studies have shown that CDDs may disrupt the endocrine system and weaken the immune system, as well as cause reproductive damage and birth defects, central and peripheral nervous system pathology, thyroid disorders, endometriosis, and diabetes. (L177, L178)
환경 거동TERRESTRIAL FATE: Based on a soil TLC study using five different soils types, 2,7-dichlorodibenzo-p-dioxin is expected to be immobile in soil(1). If applied indirectly to soils, it is not expected to move any further into the soil profile, although it may be subject to runoff or wind erosion transport(1). A single biodegradation study using two soil types has shown that about 5% of initial concns of 2,7-dichlorodibenzo-p-dioxin are metabolized to CO2 over a ten week incubation period(2). No data are currently available to suggest that dichlorodibenzo-p-dioxin is abiotically degraded within soil systems. Photodecomposition on soil surfaces is not important(3).AQUATIC FATE: 2,7-Dichlorodibenzo-p-dioxin has been found to be immobile in soil mobility studies(1) which suggests that partitioning from the water column to sediment and suspended material may be significant. In the presence of significant adsorption, volatilization may not be important. The volatilization half-life from a model environmental pond, which considers the effect of adsorption, can be estimated to be about 30 years(2,SRC)if parameters are introduced into the pond model to exclude adsorption effects, the volatilization half-life is reduced to 15.2 days(SRC). Photodegradation may have some importance in surface waters exposed to sunlight2,7-dichlorodibenzo-p-dioxin in methanol solution has been shown to decompose within several hours when exposed to sunlight(3). Based upon a predicted log Kow of 5.75(4), significant bioconcentration in aquatic organisms may occur. Aquatic hydrolysis is not expected to be important. Insufficient data are available to predict the importance of biodegradation in water. (SRC)ATMOSPHERIC FATE: Based upon a predicted vapor pressure of 1.125X10-6 mm Hg at 25 °C(1), 2,7-dichlorodibenzo-p-dioxin may exist in both the vapor and particulate phases in the ambient atmosphere(2,SRC). When associated with fly ash releases, dichlorodibenzodioxin can be expected to be very tightly adsorbed to particulates based on experimental examination of monochloro and other chlorinated dibenzo-p-dioxins(3). Vapor-phase 2,7-dichlorodibenzo-p-dioxin is degraded relatively rapidly in the atmosphere by reaction with photochemically produced hydroxyl radicalsthe half-life for this reaction has been estimated to be about 1.6 days in average air(4). The vapor phase may also be susceptible to direct photolysis. Particulate phase dibenzo-p-dioxin is susceptible to physical removal from air by both wet and dry deposition processes. (SRC)
유해 작용Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
노출 경로Oral (L177)inhalation(L177)dermal (L177)
독성 요약CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah receptor depends on the structure of the specific CDD. The change in gene expression may result from the direct interaction of the Ah receptor and its heterodimer-forming partner, the aryl hydrocarbon receptor nuclear translocator, with gene regulatory elements or the initiation of a phosphorylation/dephosphorylation cascade that subsequently activates other transcription factors. The affected genes include several oncogenes, growth factors, receptors, hormones, and drug-metabolizing enzymes. The change in transcription/translation of these genes is believed to be the cause of most of the toxic effects of CDDs. (L177)
Signs and SymptomsIn addition to chloracne, CDD exposure causes skin rashes, discoloration, and excessive body hair. (L177)
Ongoing Test StatusThe following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=33857-26-0]
Effluent ConcentrationsThe concn of dichlorodibenzo-p-dioxin occurring in fly ash from various Canadian municipal incinerators has been reported to range from 1-21 ppb(1). Dichlorodibenzodioxin has been detected in emissions from coal-fired utility boilers(1).
Soil Adsorption/MobilityUsing soil thin layer chromatography, 2,7-dichlorodibenzo-p-dioxin was found to be immobile (Rf values of 0.0) in five different types of soil(1)if applied to soils, it is not expected to move any farther into the soil profile, although it may be subject to runoff or wind erosion transport(1).
Human Toxicity ExcerptsThe most prominent acute manifestation of toxicity that has been shown in humans is chloracne, an acne-like condition that takes months or years to disappear. Clinically, this skin lesion is characterized by hyperplasia and hyperkeratosis of the interfollicular epidermis, hyperkeratosis of the sebaceous follicles, and the squamous metaplasia of the sebaceous glands that form cysts and keratinaceous comedones in a typical distribution. Data are not yet available to determine the amount, route, or duration of exposure that is necessary to cause chloracne. /Polychlorodibenzodioxins/Other less consistency reported effects from dioxin exposure in humans include aesthenia, headaches, and pain in the extremities, peripheral neuropathy, ulcers, altered liver function, enzyme induction, altered lipid metabolism, and abnormal urinary porphyrin patterns. Immune system dysfunction and altered T-cell subsets have been reported by some investigators but have not been found by others. /Polychlorodibenzodioxins/
운송 번호(UN)3077
포장분류I
위험 등급9
유해 물질 데이터33857-26-0(Hazardous Substances Data)