Phenelzine

nadil · Nardil · W-1544 · w1544-a · W 1544-A · Fenelzyne · Fenelzyna · Stinerval

식별자 및 물리적 특성

CAS No.	51-71-8
분자식	C8H12N2
평균 분자량	136.19 g/mol
단동위원소 질량	136.10004838 g/mol
SMILES	NNCCc1ccccc1
InChIKey	RMUCZJUITONUFY-UHFFFAOYSA-N
PubChem CID	3675
ChEMBL	CHEMBL1089
ChEBI	CHEBI:8060
EC No.	200-117-9
DTXSID	DTXSID2041094

화학 및 물리적 성질

XLogP	1.2
극성 표면적	38.1
수소 결합 공여자 수	2
수소 결합 수용자 수	2
회전 가능 결합 수	3
무거운 원자 수	10
형식 전하	0
복잡도	77.3
의약품	Pharmaceuticals -> Listed in ZINC15
LogP(분배 계수)	1.1
Color/Form	Liquid
용해도	1.11e+01 g/L
Human Drugs	Antidepressants -> Monoamine oxidase inhibitors (MAOI)Breast FeedingLactationAntidepressive AgentsMonoamine Oxidase InhibitorsPharmaceuticals
끓는 점	BP: 74 °C at 0.1 mm Hgbp0.1 74°
Decomposition	When heated to decomposition material emits toxic fumes of /sulfur oxides and nitrogen oxides/.
녹는점	157-161ºCCrystalsmp: 174 °C /Phenelzine hydrochloride/< 25 °C25°C
굴절률	Index of refraction: 1.5494 at 20 °C/DnD20 1.5494
Physical Description	Solid
Dissociation Constants	6.5-8
Collision Cross Section	113.9 Å² [M-N2H3]+ [CCS Type: DTBuffer gas: N2Ionization: ESI+Dataset: Antidepressants]132.72 Å² [M+K]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
밀도	1.0348 (rough estimate)
pKa(산도 계수)	8.01±0.70(Predicted)
헨리 상수	2.9×103 mol/(m3Pa) at 25℃, HSDB (2015)
NIST	Hydrazine, (2-phenylethyl)-(51-71-8)
EPA	Phenelzine (51-71-8)

안전 및 규제

GHS 분류	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
규제 정보	Phenelzine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
기타 안전 정보	IMAP assessments - Hydrazine, (2-phenylethyl)-: Human health tier I assessment
화재 가능성	This material is assumed to be combustible.
FDA 요건	The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including phenelzine sulfate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Toxic Combustion Products	Emits toxic fumes under fire conditions.
Hazard Classes and Categories	Acute Tox. 3 (100%)
소화 절차	Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials.As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.
보관 조건	Commercially available phenelzine sulfate tablets should be stored in tight containers at a temperature between 15-30 °Cthe tablets should be protected from excessive exposure to heat and light.Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Protect from heat.
정리 방법	Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site.
처리 방법	SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

용도

개요

Monoamine oxidase inhibitors (MAOIs) were the first antidepressant drugs introduced during the 1950s. Associated with many side effects and, in particular, drug–drug and drug–food interactions, their use declined with the subsequent introduction of the tricyclic antidepressants and specific serotonin reuptake inhibitors as first-line treatments for depression.

용도

Phenelzine is a MAO inhibitor which is used for treating patients with depressive characteristics such as “atypical,” “nonendogenous,” or “neurotic” conditions in which a combination of anxiety, depression, or phobia are observed. Phenelzine is not a drug of first choice, and it is used in depressions that do not respond to other medicinal drugs.