2-요오드아세트아미드

Iodoacetamide

HCID 3727CAS 144-48-9

기본 정보

표준 SMILES
NC(=O)CI
InChIKey
PGLTVOMIXTUURA-UHFFFAOYSA-N
분자식
C2H4INO
평균 분자량
184.96 g/mol
단동위원소 질량
184.93376175

개요

Iodoacetamide is a sulfhydryl alkylating reagent that forms covalent bonds with the thiol group of cysteines so the protein or peptide no longer forms disulfide bonds.

이름 및 식별자

우선 이름
Iodoacetamide
IUPAC
2-iodoacetamide
현지명
2-요오드아세트아미드
영어명
2-Iodoacetamide
분자식
C2H4INO
분자량
184.96

이름 및 동의어

2-Iodoacetamideiodoacetamide144-48-9SurautoACETAMIDE, 2-IODO-MonoiodoacetamideDTXSID9020742N-(3-Methoxy-4-butoxybenzyl)thiobarbituric acidZRH8M27S79NSC-9581DTXCID10742RefChem:389075
이름 더 보기
2-요오드아세트아마이드2-요오드아세트아미드2-요오도아세트아미드IAMIODACETAMIDEusafd-12-IodacetamidIodoethanamide2-iodo-acetamid
205-630-1USAF D-1MFCD00008028CCRIS 7710.alpha.-IodoacetamideAI3-518412-Iodo-acetamidealpha-Iodoacetamide

데이터베이스 식별자

CAS
144-48-9
PubChem CID
3727
DTXSID
DTXSID9020742
ChEMBL
CHEMBL276727
UNII
ZRH8M27S79
EC Number
205-630-1
Nikkaji
J3.270K

물성

구조 계산 물성

XLogP
-0.2
극성 표면적
43.1 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
1
회전 가능 결합 수
1
무거운 원자 수
5

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Other Nitrogen Compounds
SpringerMaterials PropertiesSchoenflies notation
LogP-0.19
Vapor Pressure0.00506 [mmHg]
Physical DescriptionCrystalline solid; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점
92 · 92-95 °C(lit.)
끓는 점
297.1 · 297.1±23.0 °C(Predicted)
밀도
2.1103 · 2.1103 (estimate)
저장 조건
2 · 2-8°C
용해도
물, 디메틸 포름아미드 및 에탄올에 용해됩니다. 메탄올에 약간 용해됩니다.
물리적 상태
수정 같은

화학적 성질

White solid in amber, foil sealed microtubes. Soluble in hot water, easily soluble in ethanol.

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H301 (99%): Toxic if swallowed [Danger Acute toxicity, oral]

P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P321, P330, P333+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 192 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Chemical: Acetamide, 2-iodo-

2-Iodoacetamide: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1건

Causes ulceration or bleeding from the stomach and other GI changes in 74-week intermittent oral studies of rats; [RTECS] May cause irritation; May cause skin and respiratory sensitization; Toxic by ingestion; [Sigma-Aldrich MSDS] See Chloroacetamide.

Hazard Classes and CategoriesAcute Tox. 3 (99%)

독성 정보

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
AC4200000
ridadr
UN 2811 6.1/PG 3
HS 번호
29241900
risk_code
25-42/43-43-36/37/38-53

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

용도 및 제조

UsesAn alkylating sulfhydryl reagent with action similar to iodoacetate; [ChemIDplus]
General Manufacturing InformationAcetamide, 2-iodo-: ACTIVE
응용 분야 · 1건

용도2-Iodoacetamide is an alkylating reagent for cysteine residues in peptide sequencing. Its actions are similar to those of iodoacetate. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibition of ribonuclease.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

관련 반응

169건

연결된 노트

불러오는 중…