글리포스페이트 아이소프로필아민 염

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water.

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.

After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash.

Accidental Release Measures: Personal precautions, protective equipment and emergency procedures: Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Keep in suitable, closed containers for disposal.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal.

Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it.

Waste treatment methods: Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product.

Worker Protection Standard (WPS) Requirements. Any product whose labeling permits use in the production of an agricultural plant on any farm, forest, nursery or greenhouse must comply with the labeling requirements of: PR Notice 93-7, "Labeling Revisions Required by the Worker Protection Standard (WPS)," andPR Notice 93-11, "Supplemental Guidance for PR Notice 93-7." Unless specifically directed in the RED, all statements required by these two PR Notices must appear on product labeling exactly as instructed in the Notices. Labels /for glyphosate isopropylamine salt were required to/ be revised by April 21, 1994, for products distributed or sold by the primary registrant or supplementally registered distributors, and by October 23, 1995, for products distributed or sold by anyone.

/Glyphosate Isopropylamine/ Products Not Primarily Intended for Home Use: Uses Within the Scope of the Worker Protection Standard (WPS) - A 12-hour restricted entry interval (REI) is required for all products with uses within the scope of the WPS, except products intended primarily for home use. The PPE for early entry should be that required for applicators of glyphosate, except any applicator requirement for an apron or respirator is waived. This REI and PPE should be inserted into the standardized statements required by PR Notice 93-7. Sole Active Ingredient End-Use Products - Labels must ... adopt the entry restrictions set forth in this section. ... Multiple Active Ingredient Products - ... A specific time period in hours or days is considered more protective than "until sprays have dried" or "dusts have settled."

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Wear the items of protective clothing the label requires: for example, non-absorbent gloves (not leather or fabric), rubber footwear (not canvas or leather), a hat, goggles, or a dust-mist filter. If no specific clothing is listed, gloves, long-sleeved shirts and long pants, and closed shoes are recommended. You can buy protective clothing and equipment at hardware stores or building supply stores.

For more Preventive Measures (Complete) data for GLYPHOSATE ISOPROPYLAMINE SALT (7 total), please visit the HSDB record page.

Tolerances are established for residues of glyphosate, including its metabolites and degradates, in or on the commodities listed below resulting from the application of glyphosate, the isopropylamine salt of glyphosate, the ethanolamine salt of glyphosate, the dimethylamine salt of glyphosate, the ammonium salt of glyphosate, and the potassium salt of glyphosate. Compliance with the following tolerance levels is to be determined by measuring only glyphosate (N-(phosphonomethyl)glycine).[Table#4604]

Tolerances are established for residues of glyphosate, including its metabolites and degradates, in or on the commodities listed below resulting from the application of glyphosate, the isopropylamine salt of glyphosate, the ethanolamine salt of glyphosate, the dimethylamine salt of glyphosate, the ammonium salt of glyphosate, and the potassium salt of glyphosate. Compliance with the following tolerance levels is to be determined by measuring only glyphosate (N-(phosphonomethyl)glycine) and its metabolite N-acetyl-glyphosate (N-acetyl-N-(phosphonomethyl)glycine; calculated as the stoichiometric equivalent of glyphosate).[Table#4605]

Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

EC50; Species: Daphnia magna (Water flea) first instar; Conditions: static bioassay without aeration, 22 °C, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/L; Concentration: 3.0 mg/L for 48 hr (95% confidence limit: 2.6-3.4 mg/L) /Liquid, 41%/

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static; Concentration: 72000 ug/L for 48 hr (95% confidence interval: 62000-83000 ug/L); Effect: intoxication, immobilization /40.7% purity/

EC50; Species: Daphnia magna (Water Flea) 1st instar; Conditions: freshwater, static; Concentration: 869000 ug/L for 48 hr (95% confidence interval: 753000-1019000 ug/L); Effect: intoxication, immobilization /62.4% purity/

EC50; Species: Daphnia magna (Water Flea) age 18 hr; Conditions: freshwater, static; Concentration: 780000 ug/L for 48 hr (95% confidence interval: 696000-874000 ug/L); Effect: intoxication, immobilization /83% purity/

For more Ecotoxicity Values (Complete) data for GLYPHOSATE ISOPROPYLAMINE SALT (56 total), please visit the HSDB record page.

EXPERIMENTAL: In lactating goats concentrations of carbon-14 label in milk were measured after giving capsules containing a 9:1 mixture of 14C-glyphosate and 14C-aminomethylphosphonic acid (AMPA) to a dose level equivalent to 120 mg/kg diet (expressed as free acid) for 5 days. Concentrations in milk (as mg equivalents glyphosate/kg whole milk) ranged from 0.019 to 0.086 mg/kg during the test period; at day 5 after the last dose the concentration was 0.006 mg/kg.

IDENTIFICATION AND USE: Glyphosate isopropylamine salt is a white odorless powder that is commonly used as a herbicide to control broadleaf weeds and grasses, in many food and non-food crops. It is an active ingredient in the herbicide Roundup. HUMAN EXPOSURE AND TOXICITY: Clinical experiences with patients exposed to Roundup either accidentally or through deliberate ingestion have been reported by investigators. Symptoms resulting from dermal exposure incidental to the use of the product included periorbital edema and chemosis of the eye, cardiovascular effects (tachycardia and elevated blood pressure), swelling and paraesthesia at the site of dermal contact and prolonged skin irritation. Deliberate ingestion resulted in more severe effects, including lethality from apparent respiratory and cardiac arrest. In glyphosate-containing herbicides abdominal pain with nausea, vomiting, and/or diarrhea are the most common manifestations of acute poisoning. These may be mild self-resolving, but in severe poisoning there may be inflammation, ulceration, or infarction. Severe diarrhea and recurrent vomiting may induce dehydration. Gastrointestinal burns and necrosis occurs with high doses of concentrated formulations and may be associated with hemorrhage. Extensive erosions of the upper gastrointestinal tract are associated with more severe systemic poisoning and a prolonged hospitalization. Severe poisonings by glyphosate-containing herbicides manifests as hypotension, cardiac dysrhythmias, renal and hepatic dysfunction, hyperkalemia, pancreatitis, pulmonary edema or pneumonitis, altered level of consciousness, and metabolic acidosis. These effects may be transient or severe, progressing over 12 to 72 hours to shock and death. The mechanism of hypotension may relate to both hypovolemia (fluids shifts and increased losses) and direct cardiotoxicity. Deaths following ingestion of Roundup alone were due to a syndrome that involved hypotension, unresponsive to iv fluids or vasopressor drugs, and sometimes pulmonary edema, in the presence of normal central venous pressure. ANIMAL STUDIES: Six groups of 10 male rabbits were treated with 76 or 114 mg/kg b.w. undiluted glyphosate isopropylamine salt for 5 days/week for 21 days. Toxicity was apparent only as dermal changes, which were more pronounced on abraded skin, but which in all cases had healed by the end of a 28-day recovery period. In glyphosate isopropylamine formulations containing surfactants, acute toxicity was due to the surfactant. In acute female dog study the joint effect of both glyphosate and the surfactant in Roundup formulation resulted in cardiac depression, which was mostly due to the surfactant since glyphosate itself increased myocardial contractility. A 4-week inhalation study was carried out on rats with a 1:3 dilution of Roundup formulation. Test concentrations of 50, 160 and 360 mg/cu m of the diluted formulation were administered as an aerosol spray for 6 hr/day, 5 days/week. An increased incidence of irritation of the nasal turbinates (subacute inflammation), trachea (mononuclear cell infiltration) and lungs (perivascular lymphoid infiltrates/aggregates) was observed among the high-dose females only. No signs of systemic toxicity were found (parameters: survival, growth, limited hematology and blood biochemistry, organ weights, limited histopathology). The genotoxic potential of the herbicide Roundup and glyphosate isopropylamine salt was studied in three different assays. No clastogenic effects were found in the mouse bone marrow micronucleus test for either of the two agents. In the Salmonella assay only Roundup was tested. It showed a weak mutagenic effect for the concn 360 ug/plate in TA98 (without metabolic activation) and 720 ug/plate in TA100 (with metabolic activation). The anaphase-telophase Allium test showed no effect for the glyphosate isopropylamine salt, but a significant increase in chromosome aberrations appeared after treatment with Roundup at concn of 1.44 and 2.88 mg/L when calculated as glyphosate isopropylamine. The most frequent aberrations observed could be characterized as disturbances of the spindle. ECOTOXICITY STUDIES: Roundup had no apparent adverse effects on reproduction, growth, or survival of deer mice 1 year after treatment of forest. The population density of Townsend chipmunks (Eutamias townsendii) appeared to initially decline in the treated area, although this response was short lived. No changes in fecundity or gonadosomatic index were observed in adult rainbow trout treated with up to 2.0 mg/L of glyphosate isopropylamine salt. In avoidance studies, rainbow trout did not avoid concentrations of the isopropylamine salt up to 10.0 mg/L. The egg stage was the least sensitive early life stage for both rainbow trout and channel catfish. Overall, the Roundup formulation was 3 to 42 times more toxic than the technical grade material.

/AQUATIC SPECIES/ Acute toxicity of isopropylamine salt to 4 aquatic invertebrates and 4 species of fish was studied. No changes in fecundity or gonadosomatic index were observed in adult rainbow trout treated with up to 2.0 mg/L. In avoidance studies, rainbow trout did not avoid concentrations of the isopropylamine salt up to 10.0 mg/L.

/AQUATIC SPECIES/ Survival of Daphnia magna in a forest pond did not show any significant variation between control and those exposed to Roundup at concentrations of 2.2, 22, and 220 kg/ha for 2, 4, and 8 days.

/AQUATIC SPECIES/ The egg stage was the least sensitive early life stage for both rainbow trout and channel catfish. ... Overall, the Roundup formulation was 3 to 42 times more toxic than the technical grade material.

/AQUATIC SPECIES/ Fingerlings (2.1 g, 5.8 cm) of rainbow trout (/Oncorhynchus mykiss/) that were exposed for 14 days to Roundup in flow-through pens in shallow streams did not show any mortality or substance-related effects at application rates of up to 220 kg a.i. (free acid)/ha. In this experiment Roundup was sprayed manually on moderately flowing forest streams in British Columbia, Canada. In the same area an aerial application of 2.2 kg a.i. (free acid)/ha did not cause mortality or obvious signs of stress in rainbow trout fingerlings in flow-through pens, which were also exposed to Roundup for 14 days. /Roundup/

For more Ecotoxicity Excerpts (Complete) data for GLYPHOSATE ISOPROPYLAMINE SALT (18 total), please visit the HSDB record page.

... In addition to biological and inhalation monitoring of glyphosate ... during application, ... each /forestry/ worker received a medical examination on the first and last days that Roundup herbicide was applied and a follow-up examination 3 weeks after the last application day. No changes were noted in hematology, clinical chemistry, electrocardiogram, pulmonary function, blood pressure, or heart rate. /Roundup herbicide/

/HUMAN EXPOSURE STUDIES/ A sensitization study was performed in 204 human volunteers with undiluted Roundup according to a modified Draize method. The summary report stated that there was no effect in any subject. The same /investigator/ reported absence of photosensitization by Roundup in volunteers. /Roundup/

/SIGNS AND SYMPTOMS/ Clinical experiences with patients exposed to Roundup either accidentally or through deliberate ingestion have been reported... Symptoms resulting from dermal exposure incidental to the use of the product included periorbital edema and chemosis of the eye, cardiovascular effects (tachycardia and elevated blood pressure), swelling and paraesthesia at the site of dermal contact and prolonged skin irritation. Deliberate ingestion resulted in more severe effects, including lethality from apparent respiratory and cardiac arrest. /Roundup/

/SIGNS AND SYMPTOMS/ Abdominal pain with nausea, vomiting, and/or diarrhea are the most common manifestations of acute poisoning. These may be mild self-resolving, but in severe poisoning there may be inflammation, ulceration, or infarction. Severe diarrhea and recurrent vomiting may induce dehydration. Gastrointestinal burns and necrosis occurs with high doses of concentrated formulations and may be associated with hemorrhage. Extensive erosions of the upper gastrointestinal tract is associated with more severe systemic poisoning and a prolonged hospitalization. /glyphosate-containing herbicides/

/SIGNS AND SYMPTOMS/ Severe poisonings manifests as hypotension, cardiac dysrhythmias, renal and hepatic dysfunction, hyperkalemia, pancreatitis, pulmonary edema or pneumonitis, altered level of consciousness, and metabolic acidosis. These effects may be transient or severe, progressing over 12 to 72 hours to shock and death. The mechanism of hypotension may relate to both hypovolemia (fluids shifts and increased losses) and direct cardiotoxicity. /glyphosate-containing herbicides/

For more Human Toxicity Excerpts (Complete) data for GLYPHOSATE ISOPROPYLAMINE SALT (16 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Acute Exposure/ The most widely used glyphosate product is Roundup which is formulated as a concentrate containing water, 41% glyphosate (as isopropylamine salt) and 15% polyoxethyleneamine (POEA). Animal studies suggest that the acute toxicity of this glyphosate formulation is due to the surfactant POEA, which has an oral LD in rat of 1200 mg/kg. Mild intoxication results mainly in transient gastrointestinal symptoms, while moderate or severe poisoning presents with gastrointestinal bleeding, hypotension, pulmonary dysfunction and renal damage. /Roundup/

/LABORATORY ANIMALS: Acute Exposure/ A study was undertaken to investigate the effects of glyphosate, surfactant, and their combination in Roundup on cardiovascular function in female beagles. They found that glyphosate alone at plasma levels ranging from 923 to 3450 mg/L, which simulates the human ingestion situation, were shown to increase the myocardial contractility. The surfactant alone considerably reduced the cardiac output, the left ventricular stroke work index and the mean arterial pressure. The joint effect of both glyphosate and the surfactant in Roundup formulation resulted in cardiac depression, which was mostly due to the surfactant since glyphosate itself increased myocardial contractility. The authors indicated that the probable cause of the observed increases in pulmonary vascular resistance index and pulmonary artery pressure was a direct vasoactive effect of glyphosate on the pulmonary artery.

/LABORATORY ANIMALS: Acute Exposure/ Male Sprague Dawley rats were exposed to Roundup intratracheally or orally and examined pathologically after 24 hr. Death rates of 60% and 80% were seen following intratracheal administration of 0.2 and 0.4 mL of 1% Roundup, respectively. These rates increased to 80% and 100% following doses of 0.2 mL and 0.4 mL of the 18% Roundup concentrate, respectively. Significant increases in lung weights were seen following intratracheal treatment with concentrated Roundup compared with saline treated controls. Animals treated intratracheally with concentrated Roundup demonstrated severe respiratory difficulties as well as foaming edema in the lungs and atria engorged with unclotted blood. Using an oral dose of concentrated Roundup of 3 mL resulted in the death of 40% of the animals while 100% of the animals died following an oral dose of 5 mL. Delayed respiratory difficulty was seen following the administration of these doses along with edema of the stomach and gut. Few clinical or pathological changes were seen following the oral administration of 1% Roundup. /Roundup/

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ A 4-week inhalation study was carried out on rats with a 1:3 dilution of Roundup formulation. Test concentrations of 50, 160 and 360 mg/cu m of the diluted formulation (equivalent to 17, 53 and 120 mg Roundup/cu m) were administered as an aerosol spray for 6 hr/day, 5 days/week. The mass median aerodynamic diameter of the test material ranged from 1.8 to 2.7 um with geometric standard deviations between 1.7 and 2.0. An increased incidence of irritation of the nasal turbinates (subacute inflammation), trachea (mononuclear cell infiltration) and lungs (perivascular lymphoid infiltrates/aggregates) was observed among the high-dose females only. No signs of systemic toxicity were found (parameters: survival, growth, limited hematology and blood biochemistry, organ weights, limited histopathology). /Roundup/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Glyphosate (Roundup) and Related Compounds/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Monitor body temperature and treat if necessary. Cover skin burns with dry sterile dressings after decontamination ... . /Glyphosate (Roundup) and Related Compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor and treat cardiac arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Glyphosate (Roundup) and Related Compounds/

EXPERIMENTAL: BACKGROUND: Although glyphosate intoxication has been considered minimally toxic in animals, severe toxicity has been observed in humans due to surfactant. /This study/ aimed to examine the potential therapeutic effects of intravenous lipid emulsion (ILE) on the patients with acute glyphosate intoxication. METHODS: This study enrolled 64 glyphosate-intoxicated patients with allocation to two groups: those treated with ILE (ILE group, n = 22), and control patients treated with only supportive (conservative) care. Control patients were selected by matching for the amount ingested and time since ingestion. Twenty-two control patients were separately selected from the 42 patients receiving supportive care only. In ILE group, 20% lipid emulsion product was injected intravenously ... for the patients who ingested less than 100 mL of glyphosate. In the patients who ingested more than 100 mL of glyphosate, the loading dose was ... according to the status of the patients, followed by a maintenance dose ... for the next 24 hr. RESULTS: Thirteen patients received high dose of ILE because the ingestion amount was more than 100 ml. None of the ILE group suffered from the complication of hypotension, while approximately 41% of the control group developed the complication. Additionally, arrhythmia was not observed in the ILE group. The incidence of mental change, respiratory failure, and acute kidney injury was similar between the two groups. CONCLUSIONS: ILE administration was associated with lower incidence of hypotension and arrhythmia in patients with acute glyphosate intoxication. ILE administration seems to be an effective treatment modality in patients who ingested sufficient amount of glyphosate herbicide that is expected to bring about significant toxicity. /Glyphosate/

LD50 Rat oral >5000 mg/kg

LD50 Goat oral 5700 mg/kg

LD50 Rabbit dermal >5000 mg/kg

LC50 Rat inhalation >1.3 mg/L air/4 hr

For more Non-Human Toxicity Values (Complete) data for GLYPHOSATE ISOPROPYLAMINE SALT (6 total), please visit the HSDB record page.

Tolerances are established for residues of glyphosate, including its metabolites and degradates, in or on the commodities listed below resulting from the application of glyphosate, the isopropylamine salt of glyphosate, the ethanolamine salt of glyphosate, the dimethylamine salt of glyphosate, the ammonium salt of glyphosate, and the potassium salt of glyphosate. Compliance with the following tolerance levels is to be determined by measuring only glyphosate (N-(phosphonomethyl)glycine).[Table#4606]

Tolerances are established for residues of glyphosate, including its metabolites and degradates, in or on the commodities listed below resulting from the application of glyphosate, the isopropylamine salt of glyphosate, the ethanolamine salt of glyphosate, the dimethylamine salt of glyphosate, the ammonium salt of glyphosate, and the potassium salt of glyphosate. Compliance with the following tolerance levels is to be determined by measuring only glyphosate (N-(phosphonomethyl)glycine) and its metabolite N-acetyl-glyphosate (N-acetyl-N-(phosphonomethyl)glycine; calculated as the stoichiometric equivalent of glyphosate).[Table#4607]

The Agency made its reregistration eligibility determination based upon the target data base required for reregistration, the current guidelines for conducting acceptable studies to generate such data and the data identified in Appendix B. Although the Agency has found that all uses of glyphosate (isopropylamine and sodium salt formulations) are eligible for reregistration, it should be understood that the Agency may take appropriate regulatory action, and/or require the submission of additional data to support the registration of products containing glyphosate, if new information comes to the Agency's attention or if the data requirements for registration (or the guidelines for generating such data) change. ... Based on the reviews of the generic data for the active ingredient glyphosate, the Agency has sufficient information on the health effects of glyphosate and on its potential for causing adverse effects in fish and wildlife and the environment. The Agency concludes that products containing glyphosate for all uses are eligible for reregistration. The Agency has determined that glyphosate products, labeled and used as specified in this Reregistration Eligibility Document, will not pose unreasonable risks or adverse effects to humans or the environment.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Isopropylamine gylphosate is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0178; Pesticide type: hebicide (growth regulator); Registration Standard Date: 06/01/86; Case Status: RED Approved 09/93; OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): isopropylamine gylphosate; Data Call-in (DCI) Date(s): 01/24/94, 02/16/94; AI Status: OPP has completed a Reregistration Eligibility Decision (RED) for the case/AI.

Used as broad spectrum post-emergence herbicide for crops, ornamentals, turf, forestry, and residential and industrial areas; [HSDB] Glyphosate usage continues to expand with the widespread adoption of glyphosate-resistant crops; [Krieger, p. 1968]

Farming (Pesticides) [Category: Industry]

For glyphosate-isopropylammonium (USEPA/OPP Pesticide Code: 103601) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

The isopropylamine salt ... is used as a herbicide to control broadleaf weeds and grasses, in many food and non-food crops and a variety of other sites including ornamentals, lawns and turf, residential areas, greenhouses, forest plantings and industrial rights-of-way.

Herbicide

A broad-spectrum, non-selective, postemergent herbicide to control grasses, broad-leaf weeds, and woody plants.

The National Pesticide Information Retrieval System (NPIRS) identifies 72 companies with active labels for products containing the chemical glyphosate-isopropylammonium. To view the complete list of companies, product names and percent glyphosate-isopropylammonium in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.

Kleenup Super Edger (Bonide Products, Inc): Active ingredient: glyphosate-isopropylammonium 0.25%; oxyfluorfen 0.25%.

Bonide Kleenup Grass & Weed Killer, Ready to Use (Bonide Products, Inc): Active ingredient: glyphosate-isopropylammonium 0.50%; sodium acifluorfen 0.12%.

Kleenup Spot Weed & Grass Killer (Bonide Products, Inc): Active ingredient: glyphosate-isopropylammonium 0.75%.

For more Formulations/Preparations (Complete) data for GLYPHOSATE ISOPROPYLAMINE SALT (36 total), please visit the HSDB record page.

Glyphosate is registered for use in over 100 countries. The original glyphosate formulation concentrate (Roundup Herbicide, Monsanto) contained the isopropylamine salt of glyphosate (41% w/v), a polyethoxylated tallow amine surfactant (15.4% w/v), and water. Over 100 different brand names comprised of many formulations have been sold worldwide by this company. In addition, other companies may now market the glyphosate molecule, and it is estimated to appear in thousands of other herbicide products. Some products contain the original isopropylamine salt, but some contain the monoammonium, sodium sesqui-, or other salts of glyphosate. Some products are dry formulations; some contain different surfactant systems, or greater or lesser amounts of total surfactant, or no surfactant at all. Glyphosate may also be sold in combination with other herbicides including various chlorphenoxy compounds, simazine, linuron, and picloram or with a fertilizer to boost plant growth, thereby enhancing lethality.

Glyphosate may also be sold in combination with other herbicides including various chlorphenoxy compounds, simazine, linuron, and picloram or with a fertilizer to boost plant growth, thereby enhancing lethality.

The glyphosate is formulated in a surfactant ...