키네틴

키네틴 · 키네틴(KINETIN) · KT · fap · cytokinin · 6-FURFURYLAMINOPURINE · KINETINE · N6-FURFURYLADENINE

식별자 및 물리적 특성

CAS No.	525-79-1
분자식	C10H9N5O
평균 분자량	215.21 g/mol
단동위원소 질량	215.08070991 g/mol
SMILES	c1coc(CNc2ncnc3nc[nH]c23)c1
InChIKey	QANMHLXAZMSUEX-UHFFFAOYSA-N
PubChem CID	3830
ChEMBL	CHEMBL228792
ChEBI	CHEBI:27407
EC No.	208-382-2
DTXSID	DTXSID9035175
현지명	키네틴

화학 및 물리적 성질

XLogP	1
극성 표면적	79.6
수소 결합 공여자 수	2
수소 결합 수용자 수	5
회전 가능 결합 수	3
무거운 원자 수	16
형식 전하	0
복잡도	239
의약품	Pharmaceuticals -> Listed in ZINC15
화장품	Skin conditioning
농약	Pesticides -> Plant Growth Regulators
Color/Form	Platelets from absolute ethanol
용해도	Slightly soluble in cold water, methanol, ethanol. Freely soluble in dilute aqueous hydrochloric acid or sodium hydroxide.H2O: 용해성
Decomposition	When heated to decomposition it emtis toxic vapors of /nitrogen oxides/.
녹는점	266-267 °C266.50 °C. @ 760.00 mm Hg269-271 °C (dec.)(lit.)
Physical Description	Solid[Merck Index] White powder[MSDSonline]
Dissociation Constants	pKa1 = 2.7pKa2 = 9.9
Collision Cross Section	144.4 Å² [M+H]+ [CCS Type: DTBuffer gas: N2Ionization: ESI+Dataset: TOXCASTSource Identifier: DTXSID9035175]143.37 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]144.1 Å² [M+H]+ [CCS Type: TW
끓는 점	355.49°C (rough estimate)
밀도	1.2639 (rough estimate)
굴절률	1.7610 (estimate)
인화점	269-271°C
저장 조건	-70°C
물리적 상태	수정 같은
pKa(산도 계수)	pKa1 2.7pKa2 9.9(at 25℃)
색상	하얀색
pH	5.5-6.5 (20°C, 10g/L in H2O, filtered suspension)
용해도	25°C에서 물(<1mg/ml)에 용해됨, 25°C에서 아세트산(49.00-51.00mg/ml), DMSO(43mg/ml), 25°C에서 에탄올(<1mg/ml) °C, 0.1 N 수산화나트륨(1% w/v), 메탄올(약간 용해됨) 및 묽은 염산 수용액 또는 수산화나트륨(자유).
Merck	14,5311
Specific Activity	≥1800units/μg protein
BRN	21703
헨리 상수	8.2×108 mol/(m3Pa) at 25℃, HSDB (2015)
화장품 원료 기능	피부 컨디셔닝
InChI	1S/C10H9N5O/c1-2-7(16-3-1)4-11-9-8-10(13-5-12-8)15-6-14-9/h1-3,5-6H,4H2,(H2,11,12,13,14,15)
InChIKey	QANMHLXAZMSUEX-UHFFFAOYSA-N
SMILES	C(Nc1ncnc2[nH]cnc12)c3ccco3
LogP(분배 계수)	1.200 (est)
NIST	Kinetin(525-79-1)
EPA	Kinetin (525-79-1)

화학적 성질

White Solid

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 9.7% (9 of 93) of reports.WarningH341 (87.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 93 reports by companies from 7 notifications to the ECHA C&L Inventory.
규제 정보	1H-Purin-6-amine, N-(2-furanylmethyl)-: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - 1H-Purin-6-amine, N-(2-furanylmethyl)-: Environment tier I assessment
유해성 요약	An irritant[MSDSonline]
Special Reports	USEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Cytokinin. EPA 078-R-95-025 December 1995. The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of February 6, 2006: http://www.epa.gov/pesticides/reregistration/status.htm]
FIFRA 요건	An exemption from the requirement of a tolerance is established for residues of cytokinins (specifically: aqueous extract of seaweed meal and kinetin) in or on all food commodities when used as plant regulators on plants, seeds, or cuttings and on all food commodities after harvest in accordance with good agricultural practices.Based on the reviews of the generic data for the active ingredients Cytokinin, the Agency has sufficient information on the health effects of Cytokinin and on its potential for causing adverse effects in fish and wildlife and the environment. The Agency has determined that Cytokinin products, labeled and used as specified in this Reregistration Eligibility Decision, will not pose unreasonable risks or adverse effects to humans or the environment. Therefore, the Agency concludes that products containing Cytokinin for registered uses listed below are eligible for product reregistration.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Kinetin is found on List D. Case No: 4107

용도

개요

Kinetin (or Vivakin) was introduced as Kinerase in the US as a new ingredient for the treatment of age related photodamage of skin. This 6- furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and was shown to be a highly potent growth factor. In vitro, it was able to delay or prevent the onset of age-related changes in skin cells without affecting cellular lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the clinical signs of photodamaged skin and demonstrated a good safety profile. It could have potential in psoriasis as well as in other proliferative skin disorders.

용도

Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures.

일반 설명

Kinetin is an artificialcytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division.