2,2'-옥시비스[2-클로로프로판]

A fire in your laboratory involving this chemical may produce dangerous vapors. Please evacuate the area immediately. As a firefighter, you should be equipped with full-body protective clothing and a self-contained breathing apparatus. You should extinguish this fire with a dry chemical, carbon dioxide or halon extinguisher. You should avoid using a water or foam extinguisher as they may cause spattering. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

INHALATION: Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

General First Aid:

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U027, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste. /Propane, 2,2'-oxybis(2-chloro-; CAS No. 108-60-1/

A potential candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Immediate precautionary measure

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Wear positive pressure breathing apparatus and special protective clothing. (USCG, 1999)

Workplace Environmental Exposure Level (WEEL): 8-hr Time-weighted Average (TWA) 3 ppm.

The NOAEL of 400 ppm (15 mg/kg/day) from the two-year dietary study in female rats was considered the point of departure for the health-based WEEL derivation. An 8-hour time-weighted average (TWA) WEEL value of 3 ppm (21 mg/m3) was derived after adjustments for duration of exposure, interindividual variability, and intraindividual variability. This exposure limit is expected to provide a significant margin of safety against any potential adverse health effects in workers.

AQUATIC FATE: Based on a measured hydrolysis rate of 65 1/hr for bis(2-chloroisopropyl) ether, it is estimated to have a hydrolysis half-life of <38.4 sec in water(1,SRC). Therefore, hydrolysis will be the predominant fate process in aquatic systems(SRC).

TERRESTRIAL FATE: Based on a measured hydrolysis rate of 65 1/hr for bis(chloro)methyl ether(1), bis(2-chloroisopropyl) ether is estimated to have a hydrolysis half-life of <38.4 sec in water(1,SRC). Therefore, hydrolysis is expected to be the predominant fate process in moist soil(SRC). No data are available regarding biodegradation or other chemical processes in soil(SRC).

ATMOSPHERIC FATE: In the atmosphere, bis(2-chloroisopropyl) ether is expected to undergo a gas-phase reaction with photochemically produced hydroxyl radicals(SRC). An estimated rate constant of 2.6X10-12 cu cm/molc-sec(1,SRC) translates to a half-life of 6.2 days(SRC) using an average atmospheric hydroxyl radical concn of 5X10+5 molc/cu cm(1).

BCIPE is moderately toxic in animal studies following acute oral, dermal, and inhalation routes of exposure. It is a severe eye irritant but is not a dermal irritant or dermal sensitizer. BCIPE was not genotoxic or mutagenic in in vitro and in vivo assays. It was not toxic in a 3-generation reproductive dietary study in rats. Short-term, repeated inhalation and oral exposure in rats produced increased liver and kidney weights and congestion. Dermal exposure in rabbits did not produce any observable adverse effects. BCIPE did not produce a statistically significant increase in tumors in two-year dietary studies in mice and rats. Although technical grade BCIPE produced increased incidences of alveolar/bronchiolar adenomas in female mice, hepatocellular carcinomas in male mice, and a low incidence of forestomach hyperplasia (in both sexes at the high-dose), further investigation with technical grade BCIPE concluded that these effects were species- and dose-specific with limited, if any, relevance to humans.

Based on a measured hydrolysis for bis(chloro)methyl ether(1), bis(2-chloroisopropyl) ether estimated to have a hydrolysis half-life of <38.4 sec in water(1,SRC). Therefore, bioconcentration in aquatic organisms will not be significant(SRC).

BIS(2-CHLOROISOPROPYL) ETHER IS INCLUDED AMONG VARIOUS CHEM IDENTIFIED IN DRINKING WATER. HERITABLE TRANSLOCATION TESTS IN MICE CONDUCTED TO DETERMINE MUTAGENICITY. ADULT MALE MICE WERE TREATED BY GAVAGE, DAILY FOR 8 WK, AT 3 DOSE LEVELS. REFERENCE CONTROLS WERE INCL AS WELL AS POSITIVE CONTROLS RECEIVING TRIETHYLENE MELAMINE IN DRINKING WATER FOR 4 WK. AFTER TREATMENT, EACH MALE WAS MATED TO 2 VIRGIN FEMALES TO PRODUCE AN F1 GENERATION, THE MALES OF WHICH WERE RAISED TO MATURITY. 100 F1 MALES PER TREATMENT GROUP WERE SELECTED & BRED TO 3 VIRGIN FEMALES EACH. PREGNANT FEMALES WERE EVALUATED AGAINST PREDETERMINED SELECTION CRITERIA TO IDENTIFY SUSPECT F1 MALES. SUSPECT F1 MALES WERE REBRED TO 3 ADDNL VIRGIN FEMALES EACH. PRESUMPTIVE F1 MALES AFTER 2 BREEDINGS WERE EXAM CYTOGENETICALLY. ALL BREEDING DATA WERE EVALUATED & CORRELATED WITH CYTOGENETIC EXAMINATIONS. PRELIMINARY EVALUATION SUGGESTS THAT HERITABLE TRANSLOCATIONS DID NOT OCCUR.

WHILE MUTAGENIC IN SALMONELLA TYPHIMURIUM TA 1535 & TA 100 WHEN TESTED IN SUSPENSION OR IN DESICCATORS & NOT REQUIRING S-9 MIX, THE MUTAGENIC ACTIVITY WAS SIGNIFICANTLY ENHANCED BY S-9 MIX (INCL AN S-9 MIX PREPD FROM HUMAN LIVER).

... In other studies, rats exposed to an atmosphere believed to be essentially saturated with dichloroisopropyl ether exhibited signs of immediate eye irritation and incoordination; the maximum exposure time causing no death was 1 hr. When rats were exposed to 700 ppm, deaths occurred after 6 hr of exposure. Autopsy revealed slight lung irritation and moderate to severe liver damage. All 10 rats survived a 6 hr exposure to 350 ppm but two of five died after an 8-hr exposure. These animals exhibited moderate lung congestion and some liver necrosis. One of four animals died after an 8 hr exposure to 175 ppm.

Inhalation of metered vapor concentration by rats: 1.0 ppm/4 hr, mortality (1/6). /From table/

Dichloroisopropyl ether evidently has little effect on rabbit skin. After 20 applications on the ear there was no response. Moderate scaliness was produced after 20 applications to the rabbit belly by the poultice technique ... dichloroisopropyl ether is minimally irritating to skin and eyes. It is absorbed through the skin and high doses can be lethal.

The rate constant for the vapor-phase reaction of bis(2-chloroisopropyl) ether with photochemically produced hydroxyl radicals has been estimated to be 2.6X10-12 cu cm/molc-sec at 25 °C which corresponds to an atmospheric half-life of about 6.2 days at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Based on a measured hydrolysis rate of 65 1/hr for bis(chloro)methyl ether(2), bis(2-chloroisopropyl) ether is estimated to have a hydrolysis half-life of < 38.4 sec in water(2,SRC).

If released to water or moist soil, bis(2-chloroisopropyl) ether will hydrolyze rapidly based on an estimated hydrolysis half-life of <38.4 sec in water. Therefore, biodegradation, bioconcentration in aquatic organisms and adsorption to soil and sediment are not expected to be significant fate processes for bis(2-chloroisopropyl) ether. If released to the atmosphere, vapor-phase bis(2-chloroisopropyl) ether is degraded by reaction with photochemically produced hydroxyl radicals (estimated half-life of 6.2 days in air). (SRC)

U027; As stipulated in 40 CFR 261.33, when propane, 2,2'-oxybis(2-chloro-, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). /CAS No. 108-60-1/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

(FL) FLORIDA 7.5 ug/l

(ME) MAINE 300 ug/l