기본 정보
- CAS
39831-55-5- 표준 SMILES
NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
FXKSEJFHKVNEFI-GCZBSULCSA-N- 분자식
- C22H47N5O21S2
- 평균 분자량
- 781.8 g/mol
- 단동위원소 질량
- 781.22049587
개요
Amikacin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
이름 및 식별자
- 우선 이름
- Amikacin Sulfate
- IUPAC
- (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid
- 현지명
- 아미카신 황산염
- 영어명
- Amikacin Disulfate
- 분자식
- C22H45N5O17S
- 분자량
- 683.68
이름 및 동의어
AMIKACIN SULFATE39831-55-5ArikayceBB-K8Amikacin (as sulfate)Amikacini sulfasAmikacin sulphateN6M33094FDNSC-755846CHEBI:2638AMIKIN IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERAMIKACIN SULFATE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER
이름 더 보기
아미카신황산염아미카신황산염(AMIKACINSULFATE)SterileAMIKACIN DISULFATE SALTAmikacin for system suitability CRSAmikacin Sulfate(Sterile)10p4mm28m8μm
DTXSID601045247AmiglydeArikayce KitSulfate, AmikacinAmiMax E SolutionNSC177001BBK8RefChem:915679
데이터베이스 식별자
- CAS
39831-55-5- PubChem CID
- 38351
- DTXSID
물성
구조 계산 물성
- 극성 표면적
- 498 Ų
- 수소 결합 공여자 수
- 17
- 수소 결합 수용자 수
- 25
- 회전 가능 결합 수
- 10
- 무거운 원자 수
- 50
- 형식 전하
- 0
- 복잡도
- 900
실험 및 물리화학적 성질
Human Drugs
Breast Feeding; Lactation; Milk, Human; Antibacterial Agents; Anti-infective Agents; Aminoglycosides
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine (Orphan designations)
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 220 · 220-230 C
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 2 O: · H2O: 50 mg/mL, 투명, 무색
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수소이온지수(pH)
- pH(10g/L, 25℃) : 2.0～4.0
- 수용성
- 50 mg/ml의 · 따뜻하게 하면 50mg/ml의 물에 용해됩니다.
- Merck
- 13 · 13,404
- BRN
- 6172633 · 6172633
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChIKey
- HIBICIOPDUTNRR-ZCBGRSKCNA-N
- EPA
- Amikacin sulfate (39831-55-5)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 5.6% (5 of 89) of reports.
Danger
H317 (89.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P260, P261, P264, P264+P265, P270, P272, P280, P302+P352, P305+P354+P338, P317, P319, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 89 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Hazard Traits - Developmental Toxicity
REACH registered substance: Amikacin bis(sulphate) (EC: 254-648-6)
Other Safety Information
IMAP assessments - D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, sulfate (1:2) (salt): Environment tier I assessment
Hazard Classes and CategoriesSkin Sens. 1 (89.9%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Amikacin sulfate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
안전 데이터
화학 및 산업
약리 정보
FDA Pharmacological Classification
AMIKACIN SULFATE
Aminoglycoside Antibacterial [EPC]; Aminoglycosides [CS]
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
응용 분야
용도Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. It is commonly used in the treatment of drug-resistant mycobacteria. It is used to study organism-directed delivery of antibiotics as well as drug resistance.
상·하류 제품 정보
상류 원료
공급사100 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
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