Guanadrel
C07035 · Guanadrel · Guanadrel USP/EP/BP · N-(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine · 1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine · 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine · Guanidine, N-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)- · 2-((1,4-dioxaspiro[4.5]decan-2-yl)methyl)guanidine
식별자 및 물리적 특성
| CAS No. | 40580-59-4 |
|---|---|
| 분자식 | C10H19N3O2 |
| 평균 분자량 | 213.28 g/mol |
| SMILES | NC(N)=NCC1COC2(CCCCC2)O1 |
| InChIKey | HPBNRIOWIXYZFK-UHFFFAOYSA-N |
| PubChem CID | 38521 |
| ChEMBL | CHEMBL1037 |
| ChEBI | CHEBI:5555 |
화학 및 물리적 성질
| 끓는 점 | 341.5±40.0 °C(Predicted) |
|---|---|
| 밀도 | 1.39±0.1 g/cm3(Predicted) |
| 저장 조건 | -20°C |
| 용해도 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 물리적 상태 | 고체 |
| pKa(산도 계수) | 12.59±0.70(Predicted) |
| 색상 | Colorless to light yellow |
용도
개요
Guanadrel is an adrenergic neuron blocker used for essential hypertension. Its mechanism of action and side effects are similar to those of guanethidine.
용도
Guanadrel is an adrenergic neuron blocker used for essential hypertension. The mechanism of action and side effects are similar to guanethidine. It is used for treating hypertension in patients who do not respond to thiazide diuretics. It can be used as an adjuvant drug in thiazide treatment for reaching an optimal level of blood pressure.