Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 3857생성일: 2026년 10월 27일
(+-)-2-아미노-3-포스포노프로피온산(AP-3)NMDA길항제
(+-)-2-아미노-3-포스포노프로피온산(AP-3)NMDA길항제 · 2-AP3 · Alanine, 3-phosphono- · 2-Amino-3-phosphonopropionic acid · (+-)-2-Amino-3-phosphonopropionic acid ( AP-3)NMDA antagonist
https://huagongshe.com/ko/chemical/3857
식별자 및 물리적 특성
| CAS No. | 20263-06-3 |
|---|
| 분자식 | C3H8NO5P |
|---|
| 평균 분자량 | 169.07 g/mol |
|---|
| 단동위원소 질량 | 169.01400899 g/mol |
|---|
| SMILES | NC(CP(=O)(O)O)C(=O)O |
|---|
| InChIKey | LBTABPSJONFLPO-UHFFFAOYSA-N |
|---|
| PubChem CID | 3857 |
|---|
| ChEMBL | CHEMBL88621 |
|---|
| ChEBI | CHEBI:28388 |
|---|
| EC No. | 633-843-3 |
|---|
| DTXSID | DTXSID40863590 |
|---|
| 현지명 | (+-)-2-아미노-3-포스포노프로피온산(AP-3)NMDA길항제 |
|---|
화학 및 물리적 성질
| XLogP | -5.2 |
|---|
| 극성 표면적 | 121 |
|---|
| 수소 결합 공여자 수 | 4 |
|---|
| 수소 결합 수용자 수 | 6 |
|---|
| 회전 가능 결합 수 | 3 |
|---|
| 무거운 원자 수 | 10 |
|---|
| 형식 전하 | 0 |
|---|
| 복잡도 | 174 |
|---|
| Physical Description | Solid |
|---|
| 끓는 점 | 481.6±55.0 °C(Predicted) |
|---|
| 밀도 | 1.763±0.06 g/cm3(Predicted) |
|---|
| 용해도 | PBS (pH 7.2): 2 mg/ml |
|---|
| 물리적 상태 | 백색 분말. |
|---|
| pKa(산도 계수) | 1.22±0.10(Predicted) |
|---|
| 색상 | White to off-white |
|---|
안전 및 규제
| GHS 분류 | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
|---|
| 관세 코드 | 2931499090 |
|---|
용도
개요
Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.
