기본 정보
- CAS
105431-72-9- 표준 SMILES
O=C1N(c2ccccc2)c2ccccc2C1(Cc1ccncc1)Cc1ccncc1- InChIKey
YEJCDKJIEMIWRQ-UHFFFAOYSA-N- 분자식
- C26H21N3O
- 평균 분자량
- 391.5 g/mol
- 단동위원소 질량
- 391.1684623
개요
Linopirdine is a member of indoles.
이름 및 식별자
- 우선 이름
- Linopirdine
- IUPAC
- 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
- 영어명
- 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
- 분자식
- C26H21N3O
- 분자량
- 391.46
이름 및 동의어
Linopirdine105431-72-9Dup 9961-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-oneDuP-996LinopirdinaI5TB3NZ94T2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-1-phenyl-3,3-bis(4-pyridylmethyl)indolin-2-one3,3-bis(4-pyridylmethyl)-1-phenylindolin-2-onelinopirdinum3,3-dipyridylmethyl-1-phenyl-2-indolinone
이름 더 보기
linopiridineLinopirdine2HClLINOPIRDINE (DUP996)Linopirdine, 10 mM in DMSOLINOPIRDINE DIHYDROCHLORIDE1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride
RefChem:924805N06BX091,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-oneDTXSID6045163MFCD008672161-Phenyl-3,3-bis(4-pyridinylmethyl)-2-indolinoneNCGC00015590-03
데이터베이스 식별자
- CAS
105431-72-9
물성
구조 계산 물성
- XLogP
- 4.1
- 극성 표면적
- 46.1 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 555
물리화학적 성질
- 녹는점
- 186 · 186-186.5 °C
- 끓는 점
- 655.9 · 655.9±50.0 °C(Predicted)
- 밀도
- 1 · 1+-.0.06 g/cm3(Predicted)
- 저장 조건
- Desiccate at RT
- 용해도
- 10 mg/mL · DMSO: >10mg/mL
- 산도 계수 (pKa)
- 6.01 · 6.01±0.10(Predicted)
- 물리적 상태
- 결정성 고체
- 색상
- 흰색에서 황백색까지
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
화학 및 산업
약리 정보
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
응용 분야
개요Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 μM in HEK293 cells voltage clamped at -60 mV).
용도Alzheimer’s disease treatment (cognition enhancer).
공급사39 곳
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