로라제팜

로라제팜 · 로라제팜(LORAZEPAM) · ATIVAN · (±)-Lorazepam solution · Lorazepam CIV (200 mg)I1D4040.998mg/mg(ai) · 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one · Quait · Tavor

https://huagongshe.com/ko/chemical/3958

식별자 및 물리적 특성

CAS No.	846-49-1
분자식	C15H10Cl2N2O2
평균 분자량	321.2 g/mol
단동위원소 질량	320.01193292 g/mol
SMILES	O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O
InChIKey	DIWRORZWFLOCLC-UHFFFAOYSA-N
PubChem CID	3958
ChEMBL	CHEMBL580
ChEBI	CHEBI:6539
EC No.	212-687-6
DTXSID	DTXSID7023225
현지명	로라제팜

화학 및 물리적 성질

XLogP	2.4
극성 표면적	61.7
수소 결합 공여자 수	2
수소 결합 수용자 수	3
회전 가능 결합 수	1
무거운 원자 수	21
형식 전하	0
복잡도	443
물질 분류	Pharmaceutical
의약품	DEA NFLIS-Drug Category -> BenzodiazepinesDEA Schedule IV Controlled Substance -> DepressantsPharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Benzodiazepines
LogP(분배 계수)	3.52.37
용해도	1.76e-02 g/L물에 거의 녹지 않으며, 에탄올(96%)에 조금 녹고, 염화메틸렌에 조금 녹거나 약간 녹습니다.
Human Drugs	Breast FeedingLactationMilk, HumanHypnotics and SedativesAnti-Anxiety AgentsBenzodiazepinesFDA approved drugs -> Active ingredientPharmaceuticalsAntiseizure medicines
녹는점	192-194166 - 168 °C166-168°C
Physical Description	Solid
Dissociation Constants	13
Collision Cross Section	165.8 Å² [M+H]+ [CCS Type: TWMethod: Major Mix IMS/Tof Calibration Kit (Waters)]169.42 Å² [M-H]-
끓는 점	533.8±50.0 °C(Predicted)
밀도	1.4835 (rough estimate)
굴절률	1.6070 (estimate)
인화점	11 °C
저장 조건	−20°C
pKa(산도 계수)	pK1 1.3pK2 11.5(at 25℃)
용해도	54mg/L(온도는 명시되지 않음)
BCS Class	1
안정성	흡습성
주요 응용	제약
InChI	1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKey	DIWRORZWFLOCLC-UHFFFAOYSA-N
SMILES	OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O
NIST	Lorazepam(846-49-1)
EPA	Lorazepam (846-49-1)

화학적 성질

White Crystalline Solid

안전 및 규제

GHS 분류	WarningH361 (93.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 102 reports by companies from 11 notifications to the ECHA C&L Inventory.
규제 정보	Hazard Traits - Developmental ToxicityDEA schedule IV controlled substanceLorazepam: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-: Human health tier I assessment
Hazard Classes and Categories	Repr. 2 (93.1%)
Treatment	General supportive and symptomatic measures are recommended. Vital signs must be monitored and the patient closely observed. When there is a risk of aspiration, induction of emesis is not recommended. Gastric lavage may be indicated if performed soon after ingestion or in symptomatic patients. Administration of activated charcoal may also limit drug absorption. (L1712)
건강 영향	They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease.
Hepatotoxicity	Lorazepam, as with other benzodiazepines, is rarely associated with serum ALT or alkaline phosphatase elevations during therapy, and considering its widescale use, clinically apparent liver injury from lorazepam is extremely rare. There has been only a single case report of symptomatic, acute liver injury from lorazepam. The latency to onset was 9 months and the clinical pattern that of a self-limited cholestatic hepatitis that resolved within 2 months of stopping. Similar isolated single cases of clinically apparent hepatitis have been reported with other benzodiazepines including alprazolam, chlordiazepoxide, clonazepam, diazepam, flurazepam and triazolam. The clinical pattern of acute liver injury from benzodiazepines is typically cholestatic and mild-to-moderate in severity with a latency of 1 to 6 months. Fever and rash are not common nor is autoantibody formation.
유해 작용	Similar to most benzodiazepines, lorazepam can induce adverse reactions such as CNS and respiratory depression, which are dose-dependent. Additional adverse effects of the drug are observed with higher doses.

용도

An anxiolytic, and anticonvulsant. Controlled substance (depressant)

일반 설명

Lorazepam, 7-chloro-5-(2-chlorophenyl)-3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one(Ativan), is the 2'-chloro derivative of oxazepam. In keepingwith overall SARs, the 2'-chloro substituent increases activity.As with oxazepam, metabolism is relatively rapid anduncomplicated because of the 3-hydroxyl group in the compound.Thus, it also has short half-life (2–6 hours) and similarpharmacological activity.