기본 정보
- CAS
36519-31-0- 표준 SMILES
CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.O=S(=O)(O)O- InChIKey
BNPSSFBOAGDEEL-UHFFFAOYSA-N- 분자식
- C26H44N2O10S
- 평균 분자량
- 576.7 g/mol
- 단동위원소 질량
- 576.27166678
개요
Albuterol sulfate is an ethanolamine sulfate salt. It is functionally related to an albuterol.
이름 및 식별자
- 우선 이름
- Albuterol Sulfate
- IUPAC
- bis(4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol);sulfuric acid
- 현지명
- 살부타몰헤미술페이트
- 영어명
- SALBUTAMOL HEMISULFATE
- 분자식
- C13H23NO7S
- 분자량
- 337.38922
이름 및 동의어
ALBUTEROL SULFATEVenetlinLoftanVolmaxSalbutamol SulphateAccuNebProventil-HFAVentolin RotacapsSch 13949W sulfateProAirProair RespiclickVentolin HFA
이름 더 보기
살부타몰헤미술페이트dl-salbutamolsulfate(+-)-ysulfate(2:1)(salt)
VoSpire ERSultanolVentilastinBuventolEcoventSalbumolAlbuterol SulphateProair HFA
데이터베이스 식별자
- CAS
36519-31-0、51022-70-9、67713-16-0- PubChem CID
- 39859
- DTXSID
DTXSID10881180- ChEMBL
CHEMBL1441059- ChEBI
CHEBI:2550- UNII
- 021SEF3731
- EC Number
- 690-790-9
물성
구조 계산 물성
- 극성 표면적
- 228 Ų
- 수소 결합 공여자 수
- 10
- 수소 결합 수용자 수
- 12
- 회전 가능 결합 수
- 10
- 무거운 원자 수
- 39
- 형식 전하
- 0
- 복잡도
- 309
실험 및 물리화학적 성질
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Asthmatic Agents; Bronchodilator Agents; Beta Adrenergic Agonists
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS ClassificationNot Classified
유해성 정보
DOT Hazard Classification
Hexotonal
UN0393
Div 1.1 Explosives (with a mass explosion hazard) (49 eCFR § 173.50)
Hazard Classes and CategoriesNot Classified
DHS Chemicals of Interest (COI)
Torpex
A Commercial Grade
5000
A Commercial Grade
400
Explosive chemical that can be released at a facility.
독성 정보
Exposure RoutesSystemic absorption is rapid following aerosol administration.
Toxicity Summary
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
화학 및 산업
약리 정보
Metabolism/Metabolites
Hydrolyzed by esterases in tissue and blood to the active compound colterol. The drug is also conjugatively metabolized to salbutamol 4'-O-sulfate. Route of Elimination: Approximately 72% of the inhaled dose is excreted in the urine within 24 hours, 28% as unchanged drug and 44% as metabolite. Half Life: 1.6 hours
FDA Pharmacological Classification
ALBUTEROL SULFATE
Adrenergic beta2-Agonists [MoA]; beta2-Adrenergic Agonist [EPC]
MeSH Pharmacological Classification
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
용도 및 제조
UsesFor symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD.
공급사4 곳
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]
Shenzhen Excellent Biotech Co., Ltd.13480692018 · [email protected]
南京克罗托鲁宁医药科技有限公司13382066392
Hefei TNJ Chemical Industry Co.,Ltd.
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