멜라티온
말라티온 · 멜라티온 · tak · MERCAPTO · Malphos · Malation · maldison · 4049
식별자 및 물리적 특성
| CAS No. | 121-75-5 |
|---|---|
| 분자식 | C10H19O6PS2 |
| 평균 분자량 | 330.4 g/mol |
| 단동위원소 질량 | 330.03606696 g/mol |
| SMILES | CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC |
| InChIKey | JXSJBGJIGXNWCI-UHFFFAOYSA-N |
| PubChem CID | 4004 |
| ChEMBL | CHEMBL1200468 |
| ChEBI | CHEBI:141474 |
| EC No. | 204-497-7 |
| DTXSID | DTXSID4020791 |
| 현지명 | 멜라티온 |
화학 및 물리적 성질
| XLogP | 2.4 |
|---|---|
| 극성 표면적 | 128 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 8 |
| 회전 가능 결합 수 | 11 |
| 무거운 원자 수 | 19 |
| 형식 전하 | 0 |
| 복잡도 | 341 |
| SpringerMaterials Properties | Boiling point |
| 농약 | PesticidesPesticide -> EPA IRISAcaricides, InsecticidesActive substance -> EU Pesticides database: ApprovedPesticides -> Organophosphate InsecticidesPesticide (Malathion) -> USDA PDB |
| LogP(분배 계수) | log Kow = 2.362.89 |
| 냄새 | Skunk-like odorGarlic-like odorMercaptan odor |
| 밀도 | 1.234 at 77 °F (USCG, 1999) - Denser than waterwill sink1.2076 g/cu cm at 20 °CRelative density (water = 1): 1.21.2076 @ 20°C1.21 |
| Color/Form | Colorless or slightly yellowClear colorless liquid when pureDeep-brown to yellow liquid ... [Note: A solid below 37 degrees F] |
| 용해도 | less than 1 mg/mL at 70.7 °F (NTP, 1992)In water, 143 mg/L at 20 °CMiscible with many organic solvents including alcohols, esters, ketones, ethers, aromatic and alkylated aromatic hydrocarbons and vegetable oils. Limited solubility in certain paraffin hydrocarbonsSoluble in ethanol, benzene and ethyl ether1.65e-01 g/L물에 약간 용해되며 아세톤, 사이클로헥산, 에탄올(96%) 및 식물성 오일과 섞입니다. |
| Corrosivity | Corrosive to iron and some other metalsMalathion will attack some forms of plastics, rubber, and coatingsCorrosive to metals |
| 인화점 | greater than 325 °F (NTP, 1992)Above 325 °F (tag open cup)163 °C c.c.>325 °F (open-cup)(oc) >325 °F-18 °C |
| Human Drugs | Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntiparasitic AgentsInsecticidesFDA approved drugs -> Active ingredient |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| 끓는 점 | 313 to 315 °F at 0.7 mmHg (decomposes) (NTP, 1992)156-157 °C at 7.00E-01 mm HgBP: 156-157 °C at 0.7 mm Hg140 °F (decomposes)156°C |
| 녹는점 | 2.85°C |
| 증기압 | 7.95 at 25 °C (gas saturation method-GC, Kim et al., 1984) |
| 굴절률 | nD25 1.4985 |
| 저장 조건 | APPROX 4°C |
| 물리적 상태 | 액체 |
| 비중 | 1.23 (25℃) |
| 색상 | Light yellow to yellow |
| 생물학적 소스 | human |
| 용해도 | 0.0145g/100mL |
| 비열 | Cp(gas): 0.1 J/(g·K), at 25℃ |
| Specific Activity | 15-21nmol/min·mg |
| 헨리 상수 | (x 10-9 atmm3/mol): 4.89 at 25 °C (wetted-wall column, Fendinger and Glotfelty, 1990) |
| 안정성 | 안정적인. 산화제, 금속과 호환되지 않습니다. |
| 주요 응용 | 농업 |
| InChI | 1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3 |
| InChIKey | JXSJBGJIGXNWCI-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC |
| LogP(분배 계수) | 2.360 |
| NIST | Malathion(121-75-5) |
| EPA | Malathion (121-75-5) |
화학적 성질
Malathion is a deep-brown to yellow liquid with a garlic-like odor. Clear and colorless when pure; freezing/melting point5 3C;
안전 및 규제
| GHS 분류 | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)DangerH302 (97.4%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P316, P321, P330, P333+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| 규제 정보 | Hazard Traits - CarcinogenicityDevelopmental ToxicityEnvironmental toxNeurotoxicityCommission Regulation (EC) No 451/20002010/17/EU, Reg. (EU) 2017/1527, Reg. (EU) 2018/1495, Reg. (EU) 2022/378, Reg. (EU) 2023/689, Reg. (EU) No 540/2011Malathion: HSNO Approval: HSR003011 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 기타 안전 정보 | IMAP assessments - Butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester: Environment tier I assessment |
| 운송 라벨(DOT) | Poison |
| 화재 위험 | Special Hazards of Combustion Products: Vapors and fumes from fires are hazardous. They include sulfur dioxide and phosphoric acid.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion if formulations contain flammable/explosive solvents. |
| 화재 가능성 | Malathion is combustible but ignites with difficulty.Malathion is a noncombustible ... liquid.The commercially available malathion 0.5% lotion is flammable and should not be exposed to an open flame (e.g., a lighted cigarette) or heat sources (e.g., hair dryer, electric curlers). |
| 건강 유해성 | Exposure to fumes from a fire or to liquid causes headache, blurred vision, constricted pupils of the eyes, weakness, nausea, cramps, diarrhea, and tightness in the chest. Muscles twitch and convulsions may follow. The symptoms may develop over a period of 8 hours. (USCG, 1999) |
용도
개요
Malathion, a clear amber liquid, is sparingly soluble in water but soluble in a majority of organic solvents. The U.S. Environmental Protection Agency (U.S. EPA) grouped malathion under GUP, meaning general use pesticide. It is used as an insecticide as well as an acaricide for the control of pests. Malathion is used for the control of sucking insects and chewing insects on fruits and vegetables. Malathion is an effective insecticide for the control of several household pests such as houseflies, cockroaches, mosquitoes, aphids, animal ectoparasites, and human head and body lice. Malathion is also found in formulations with many other pesticides.
용도
Malathion is used to control a wide spectrum of insect pests in many types of crops and disease vectors in public health programmes. It is also used to control ectoparasites of both humans and animals.
일반 설명
Malathion, 2-[(dimethoxyphosphinothioyl)thio]butanedioic acid diethyl ester, is a water-insolublephosphodithioate ester that has been used as an agriculturalinsecticide. Malathion is a poor inhibitor of cholinesterases.Its effectiveness as a safe insecticide is a result of the differentrates at which humans and insects metabolize the chemical.Microsomal oxidation, which causes desulfuration,occurs slowly to form the phosphothioate (malaoxon),which is 10,000 times more active than the phosphodithioate(malathion) as a cholinesterase inhibitor. Insects detoxifythe phosphothioate by a phosphatase, forming dimethylphosphorothioate, which is inactive as an inhibitor.Humans, however, can rapidly hydrolyze malathion by acarboxyesterase enzyme, yielding malathion acid, a stillpoorer inhibitor of AChE. Phosphatases and carboxyesterasesfurther metabolize malathion acid to dimethylphosphothioate.