Phenazepam
CJC-1295 with DAC · PHENAZEPAM · bd98 · fenazepam · Phenazapam · PHENATZEPAM · Phenazepam (CRM) · IFLAB-BB F0133-0017
식별자 및 물리적 특성
| CAS No. | 51753-57-2 |
|---|---|
| 분자식 | C15H10BrClN2O |
| 평균 분자량 | 349.61 g/mol |
| 단동위원소 질량 | 347.9665 g/mol |
| SMILES | O=C1CN=C(c2ccccc2Cl)c2cc(Br)ccc2N1 |
| InChIKey | CGMJQQJSWIRRRL-UHFFFAOYSA-N |
| PubChem CID | 40113 |
| ChEMBL | CHEMBL1709464 |
| EC No. | 682-231-2 |
| DTXSID | DTXSID00199685 |
화학 및 물리적 성질
| XLogP | 3.3 |
|---|---|
| 극성 표면적 | 41.5 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 20 |
| 형식 전하 | 0 |
| 복잡도 | 415 |
| 의약품 | DEA NFLIS-Drug Category -> BenzodiazepinesPharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds |
| LogP(분배 계수) | 3.3 |
| Collision Cross Section | 166 Ų [M+H]+ [CCS Type: TWMethod: Major Mix IMS/Tof Calibration Kit (Waters)] |
| 녹는점 | 214-224°C |
| 끓는 점 | 493.0±45.0 °C(Predicted) |
| 밀도 | 1.61±0.1 g/cm3(Predicted) |
| 인화점 | 2℃ |
| 저장 조건 | Controlled Substance, -20°C Freezer |
| 용해도 | 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨) |
| 물리적 상태 | 고체 |
| pKa(산도 계수) | 11.58±0.70(Predicted) |
| 색상 | 옅은 노랑 |
| 주요 응용 | 임상 시험 |
| InChI | 1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20) |
| InChIKey | CGMJQQJSWIRRRL-UHFFFAOYSA-N |
| SMILES | Clc1ccccc1C2=NCC(=O)Nc3ccc(Br)cc23 |
화학적 성질
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is Pale Yellow Solid
안전 및 규제
| GHS 분류 | DangerH319 (95.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P203, P260, P263, P264, P264+P265, P270, P280, P305+P351+P338, P318, P337+P317, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Eye Irrit. 2 (95.2%) |
| 수질 위해 등급(WGK) | 2 |
| 운송 번호(UN) | UN 1648 3 / PGII |
| 독성 | LD50 ipr-rat: 720 mg/kg KHFZAN 13(10),108,79 |
| 위험 문구(R) | 11-20/21/22-36 |
| 위험 표시 | F,Xn |
| 안전 문구(S) | 16-36/37 |
| 위험 등급 | Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralEye Irrit. 2Flam. Liq. 2Muta. 1B |
| 저장 분류 | 3 - Flammable liquids |
용도
개요
Phenazepam (CRM) (Item No. ISO60172) is a certified reference material categorized as a benzodiazepine. It has sedative and hypnotic properties and has been detected in illicit tablets. This product is intended for research and forensic applications.
용도
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety
일반 설명
Phenazepam, a benzodiazepine drug produced in Russia, is used in Europe as an anxiolytic, anticonvulsant, and muscle relaxant. Although not used therapeutically in the US, the drug can be purchased on the internet for “laboratory research” purposes. Cases of abuse have been reported from European countries such as Sweden and Russia to states including New York, Kentucky, North Carolina, and Georgia.