Carteolol Hydrochloride

HCID 40127

기본 정보

CAS
51781-21-6
표준 SMILES
CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2.Cl
InChIKey
FYBXRCFPOTXTJF-UHFFFAOYSA-N
분자식
C16H25ClN2O3
평균 분자량
328.83 g/mol
단동위원소 질량
328.1553704

개요

Carteolol Hydrochloride is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects. It is used for treatment of hypertension and certain arrhythmias, and as an anti-angina and antiglaucoma agent. (NCI04)

이름 및 식별자

우선 이름
Carteolol Hydrochloride
IUPAC
5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
영어명
Carteolol hydrochloride
분자식
C16H25ClN2O3
분자량
328.83

이름 및 동의어

carteolol hydrochloride51781-21-6Carteolol HClCartrolOcupressAbbott-43326OPC-1085TeopticDTXSID4045478NSC-3009064797W6I0T4DTXCID2025478
이름 더 보기
endakoc1085TenaletCarteolCartelomikelanopc1085
5-(2-Hydroxy-3-tert-butylamino)propoxy-3,4-dihydrocarbostyril hydrochloride5-(3-(tert-Butylamino)-2-hydroxypropoxy)-3,4-dihydrocarbostyril monohydrochlorideNSC3009065-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-2(1H)-quinolinone hydrochloride5-(3-tert-Butylamino-2-hydroxy-propoxy)-3,4-dihydro-2(1H)-chinolinon-hydrochloridCHEBI:34385-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril monohydrochloride5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone Hydrochloride

데이터베이스 식별자

CAS
51781-21-6
PubChem CID
40127
DTXSID
DTXSID4045478
ChEMBL
CHEMBL1201002
UNII
4797W6I0T4
EC Number
257-415-7

물성

구조 계산 물성

극성 표면적
70.6 Ų
수소 결합 공여자 수
4
수소 결합 수용자 수
4
회전 가능 결합 수
6
무거운 원자 수
22

실험 및 물리화학적 성질

Human Drugs · 3건

Breast Feeding; Lactation; Milk, Human; Adrenergic Beta-Antagonists; Antiglaucoma Agents

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점
278 °C · 278°C
저장 조건
Refrigerator
용해도
96 % · 물에 용해되고, 메탄올에 거의 용해되지 않으며, 에탄올에 96% 약간 용해되고, 염화메틸렌에는 거의 용해되지 않습니다.
물리적 상태
Solid
색상
흰색에서 황백색까지
Merck
14 · 14,1866

화학적 성질

Crystalline Solid

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.

Warning

H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (83.3%)

독성 정보

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

rtecs
VC8282000
독성
LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang)
HS 번호
2933790002

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

CARTEOLOL HYDROCHLORIDE

Adrenergic beta-Antagonists [MoA]; beta-Adrenergic Blocker [EPC]

MeSH Pharmacological Classification · 4건

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

상·하류 제품 정보

공급사100 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
艾吉析科技(上海)有限公司17717235263 · [email protected]
湖北海克斯生化有限公司17362916295; 17362916295 · [email protected]

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