기본 정보
- CAS
51781-21-6- 표준 SMILES
CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2.Cl- InChIKey
FYBXRCFPOTXTJF-UHFFFAOYSA-N- 분자식
- C16H25ClN2O3
- 평균 분자량
- 328.83 g/mol
- 단동위원소 질량
- 328.1553704
개요
Carteolol Hydrochloride is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects. It is used for treatment of hypertension and certain arrhythmias, and as an anti-angina and antiglaucoma agent. (NCI04)
이름 및 식별자
- 우선 이름
- Carteolol Hydrochloride
- IUPAC
- 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
- 영어명
- Carteolol hydrochloride
- 분자식
- C16H25ClN2O3
- 분자량
- 328.83
이름 및 동의어
이름 더 보기
데이터베이스 식별자
- CAS
51781-21-6- PubChem CID
- 40127
- DTXSID
DTXSID4045478- ChEMBL
CHEMBL1201002- UNII
- 4797W6I0T4
- EC Number
- 257-415-7
물성
구조 계산 물성
- 극성 표면적
- 70.6 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 354
실험 및 물리화학적 성질
Human Drugs
Breast Feeding; Lactation; Milk, Human; Adrenergic Beta-Antagonists; Antiglaucoma Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 278 °C · 278°C
- 저장 조건
- Refrigerator
- 용해도
- 96 % · 물에 용해되고, 메탄올에 거의 용해되지 않으며, 에탄올에 96% 약간 용해되고, 염화메틸렌에는 거의 용해되지 않습니다.
- 물리적 상태
- Solid
- 색상
- 흰색에서 황백색까지
- Merck
- 14 · 14,1866
- InChI
- InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H
- InChIKey
- FYBXRCFPOTXTJF-UHFFFAOYSA-N
- SMILES
- C12CCC(=O)NC=1C=CC=C2OCC(O)CNC(C)(C)C.Cl
화학적 성질
Crystalline Solid
안전 및 규제
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.
Warning
H302 (83.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
독성 정보
안전 데이터
- rtecs
- VC8282000
- 독성
- LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang)
- HS 번호
- 2933790002
화학 및 산업
약리 정보
FDA Pharmacological Classification
CARTEOLOL HYDROCHLORIDE
Adrenergic beta-Antagonists [MoA]; beta-Adrenergic Blocker [EPC]
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
상·하류 제품 정보
하류 제품
공급사100 곳
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