Quisqualic Acid

HCID 40539CAS 52809-07-1
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
N[C@@H](Cn1oc(=O)[nH]c1=O)C(=O)O
InChIKey
ASNFTDCKZKHJSW-REOHCLBHSA-N
분자식
C5H7N3O5
평균 분자량
189.13 g/mol
단동위원소 질량
189.03857032

개요

Quisqualic acid is a non-proteinogenic alpha-amino acid.

이름 및 식별자

우선 이름
Quisqualic Acid
IUPAC
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
영어명
Quisqualic acid
분자식
C5H7N3O5
분자량
189.13

이름 및 동의어

QUISQUALIC ACID52809-07-1DTXSID208969278OC22C1B991,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-(2S)-2-azaniumyl-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoateRefChem:389258DTXCID601326364QuisqualateL-Quisqualic acid(+)-Quisqualic acid(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
이름 더 보기
(+)-QuisqualicAci()-QUISQUALIC ACIDL(+)-QUISQUALIC ACIDQuisqualic acid (7CI)QUISQUALIC ACID USP/EP/BP
Quisqualinic acid[3H]quisqualate(S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acidL-quisqualic-acid1mm7MFCD00069337C5H7N3O5CHEMBL168279

데이터베이스 식별자

CAS
52809-07-1
PubChem CID
40539
DTXSID
DTXSID20896927
ChEMBL
CHEMBL168279、CHEMBL279956
ChEBI
CHEBI:8734
UNII
8OC22C1B99
EC Number
637-070-2
Nikkaji
J9.726H

물성

구조 계산 물성

XLogP
-3.9
극성 표면적
122 Ų
수소 결합 공여자 수
3
수소 결합 수용자 수
6
회전 가능 결합 수
3
무거운 원자 수
13

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15

물리화학적 성질

녹는점
185 · 185-187°C dec.
끓는 점
324.36 °C · 324.36°C (rough estimate)
밀도
1.6649 · 1.6649 (rough estimate)
굴절률
1.619 · 1.6190 (estimate)
저장 조건
2 · 2-8°C
용해도
4 OH · NH4OH 1 M: 20 mg/mL, 투명, 무색

화학적 성질

Off-White Solid

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302+H312+H332 (41.2%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 68 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (100%)

안전 데이터

wgk
3
risk_code
20/21/22
hazard_code
Xn
safety_code
26-36
F 고인화성물질
10
스토리지 클래스
11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationDrugs that bind to and activate excitatory amino acid receptors.
응용 분야 · 3건

개요L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.

용도Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.

일반 설명Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

공급사50 곳

湖北万得化工有限公司15377098680 15377098680 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]

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